DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8159 and nom

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001262384.1	Gene:	nom / 41038	FlyBaseID:	FBgn0037617	Length:	370	Species:	Drosophila melanogaster

Alignment Length:	398	Identity:	143/398 - (35%)
Similarity:	205/398 - (51%)	Gaps:	58/398 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLQNVCRVCASSTDNSKSLKLFNSGACKVLQQINLLTGVLLQCEPGLPDWMCETCQTDLKSAISF 65
            ||.||||||..|....|:::||..|...:|::|.|:||:|||..|..||.:|..|||||:||:.|
  Fly     1 MLINVCRVCGRSRLCPKAVELFKPGRQDILRRIQLITGILLQQIPNAPDMVCFCCQTDLQSAMIF 65

  Fly    66 RDRCLRSQKIF-------------EESLVRNEEDTFRSSVRRSARSQRQRHEDTAPKTPASPLEV 117
            |.:|:..||.:             |:.:..|:..|.:.:.:|    :|.|     |:.|...:::
  Fly    66 RRQCILQQKKWVPLLQSDKVGASEEKKVEPNDPSTKKKTTKR----RRGR-----PRMPLEIVDI 121

  Fly   118 MIKLESLSNGDEEDDGIDHLDSCNEADMELAIKAMSSSTEDDGTTSPVRLKR---TRRRGLKKGG 179
            ::..||.::..|...|       :|.|..:.|     |.|.|.|.|.|.|:.   ....||:...
  Fly   122 VVTNESKASAGESVGG-------DEFDQPVEI-----SNEPDATDSDVNLEEIDLPDEDGLESDH 174

  Fly   180 KGENRTKVTLPVFFCDQCGNNITGKSSFDRHLRKHSGIRPFQCELCPARFLSSGELKGHQVM-HT 243
            ...|     :.:..||.||.....|||..||..:|:||||:.|:.||..||.:.|||.|.:. ||
  Fly   175 DLPN-----VQIHKCDTCGIIKNNKSSLVRHQFEHNGIRPYPCKECPKTFLVASELKAHNLTHHT 234

  Fly   244 GDRKFQCRYCDRTYVNYSGRLRHERTHTNDRPFICAQCGKSFTNSYILKNHMLIHTGERLFRCEL 308
            .:..|.||||||.|.:..||.:|||.|||:|||:|.||||:||.:.|||.||.:|...|.:.|::
  Fly   235 LEPPFACRYCDRRYFSVVGRKKHERVHTNERPFVCDQCGKAFTRTCILKAHMAVHQVVRKYSCDV 299

  Fly   309 CHRSFARPTHLKTHFRSNTHKHNLEKSMADAGGVQLSPSQSADQVKFVTEKEPEAEADAFTIEVP 373
            |.|||:...||.|||.|||||.|.|        ...|.|:....:.|.::       :.::...|
  Fly   300 CDRSFSLKKHLATHFISNTHKRNAE--------AVTSSSEYMSMLSFESD-------ETWSQGTP 349

  Fly   374 LPAEQEQD 381
            |....::|
  Fly   350 LTTSIDED 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	34/85 (40%)
		C2H2 Zn finger	194..214	CDD:275368	9/19 (47%)
		COG5048	<197..322	CDD:227381	63/125 (50%)
		zf-H2C2_2	206..231	CDD:290200	12/24 (50%)
		C2H2 Zn finger	222..242	CDD:275368	9/20 (45%)
		C2H2 Zn finger	250..270	CDD:275368	12/19 (63%)
		zf-H2C2_2	265..287	CDD:290200	15/21 (71%)
		C2H2 Zn finger	278..298	CDD:275368	12/19 (63%)
		zf-H2C2_2	291..315	CDD:290200	11/23 (48%)
		C2H2 Zn finger	306..328	CDD:275368	12/21 (57%)
nom	NP_001262384.1	zf-AD	5..76	CDD:214871	34/70 (49%)
		C2H2 Zn finger	184..204	CDD:275368	9/19 (47%)
		C2H2 Zn finger	212..261	CDD:275368	24/48 (50%)
		zf-H2C2_2	255..278	CDD:290200	15/22 (68%)
		C2H2 Zn finger	269..289	CDD:275368	12/19 (63%)
		zf-H2C2_2	282..305	CDD:290200	10/22 (45%)
		C2H2 Zn finger	297..313	CDD:275368	7/15 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447748
Domainoid	1	1.000	48	1.000	Domainoid score	I19075
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120097
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890