DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8159 and Zif

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	102/396 - (25%)
Similarity:	170/396 - (42%)	Gaps:	86/396 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRVCASSTDNSKSL-KLFNSGACKVLQQINLLTGVL---LQCEPGLPDWMCETCQTDLKSAISFR 66
            ||||.:.::..:.| ::...|.....:.:..|.||.   |.....:||.:|::|:.:|..|..||
  Fly    10 CRVCLAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAYQFR 74

  Fly    67 DRCLRSQKIFEESL----VRNEEDTFRSSVRRSARSQRQRHEDTAPKTPASPLEVMIKLESLSNG 127
            ::.||.|...||..    :.:|.|..  .::....||:|..|:            |..||..:.|
  Fly    75 EKALRKQMEIEEYCRELGLLDESDVM--MIKEEDGSQQQCDEE------------MYILEETTTG 125

  Fly   128 DEE----------------------DDGIDHLD-----SCNEADMELAIKAMSSSTE-------- 157
            :||                      .|.|::|:     ..|....|:.:::.....|
  Fly   126 EEEHQEEKGHEEYLEVDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLAL 190

  Fly   158 DDGTTSPVRLKRTR-RRGL---------KKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHLR 212
            .:...:.::.:|.| ||||         :|||            :.||.|||....:.....|.|
  Fly   191 QEAAKASLKARRGRVRRGLNSLTTSDGTEKGG------------YICDVCGNFYEKRGRMMEHRR 243

  Fly   213 KHSGIRPFQCELCPARFLSSGELKGHQVMHTGDRKFQCRYCDRTYVNYSGRLRHERTHTNDRPFI 277
            :|.||..:.||||.|:|....:|:.|...|||.:.::|.:|.|.:...|....||..|...:|::
  Fly   244 RHDGICQYACELCDAKFQVREQLRKHMYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYV 308

  Fly   278 CAQCGKSFTNSYILKNHMLIHTGERLFRCELCHRSFARPTHLKTHFRSNTHKH--NLEKSM---- 336
            |..|.|:|..::.|..|.|||:..:|:||:.|::.|....|::.|..:..|::  .|.:||
  Fly   309 CKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFRLLHHMRQHEETKLHQNAVMLAESMKVEM 373

  Fly   337 -ADAGG 341
             |:.||
  Fly   374 VAEQGG 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	21/75 (28%)
		C2H2 Zn finger	194..214	CDD:275368	7/19 (37%)
		COG5048	<197..322	CDD:227381	42/124 (34%)
		zf-H2C2_2	206..231	CDD:290200	11/24 (46%)
		C2H2 Zn finger	222..242	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		zf-H2C2_2	265..287	CDD:290200	8/21 (38%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		zf-H2C2_2	291..315	CDD:290200	10/23 (43%)
		C2H2 Zn finger	306..328	CDD:275368	5/21 (24%)
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	22/76 (29%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		COG5048	<250..369	CDD:227381	37/118 (31%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	266..288	CDD:290200	8/21 (38%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		zf-H2C2_2	294..318	CDD:290200	8/23 (35%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..353	CDD:275368	4/15 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960