DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8159 and Zfp189

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001101400.1	Gene:	Zfp189 / 313219	RGDID:	1306510	Length:	608	Species:	Rattus norvegicus

Alignment Length:	247	Identity:	75/247 - (30%)
Similarity:	117/247 - (47%)	Gaps:	21/247 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 RHEDTAPKTPASPLEVMIKLESL------SNGDEEDDGIDHLDSCNEADMELAIKAMSSSTEDDG 160
            |:||..| |....:|..|:.:.:      |..|::..|.:..:.....|.:..|  .......|.
  Rat    44 RNEDEEP-TVKEEIEKDIEPQGIIVTRIKSELDQDPMGSETFELVGRLDKQRGI--FLWEIPRDS 105

  Fly   161 TTSPVRLKRTRRRGLKKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHLRKHSGIRPFQCELC 225
            .|...::.|......|:....|...|       |::||.....|:.|.:|.|.|:|.:||||..|
  Rat   106 LTEEQKMFRGHTNVRKRPNSEEKCHK-------CEECGKRFVRKAHFIQHQRVHTGEKPFQCNEC 163

  Fly   226 PARFLSSGELKGHQVMHTGDRKFQCRYCDRTYVNYSGRLRHERTHTNDRPFICAQCGKSFTNSYI 290
            ...|..|..:..||.:|||:|.::|.||.:|:...|..:||:|.||.:||:.|.||.:||:....
  Rat   164 GKSFSRSSFVIEHQRIHTGERPYECNYCGKTFSVSSTLIRHQRIHTGERPYQCNQCKQSFSQRRS 228

  Fly   291 LKNHMLIHTGERLFRCELCHRSFARPTHLKTHFRSNT-----HKHNLEKSMA 337
            |..|..|||||:..:|..|.::|:..:||..|.|::|     |....:||.:
  Rat   229 LVKHQRIHTGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFS 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871
		C2H2 Zn finger	194..214	CDD:275368	7/19 (37%)
		COG5048	<197..322	CDD:227381	50/124 (40%)
		zf-H2C2_2	206..231	CDD:290200	11/24 (46%)
		C2H2 Zn finger	222..242	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		zf-H2C2_2	265..287	CDD:290200	12/21 (57%)
		C2H2 Zn finger	278..298	CDD:275368	7/19 (37%)
		zf-H2C2_2	291..315	CDD:290200	10/23 (43%)
		C2H2 Zn finger	306..328	CDD:275368	8/26 (31%)
Zfp189	NP_001101400.1	KRAB_A-box	<10..39	CDD:143639
		COG5048	116..506	CDD:227381	60/172 (35%)
		C2H2 Zn finger	132..152	CDD:275368	7/19 (37%)
		zf-H2C2_2	144..169	CDD:290200	11/24 (46%)
		C2H2 Zn finger	160..180	CDD:275368	6/19 (32%)
		zf-H2C2_2	175..196	CDD:290200	10/20 (50%)
		C2H2 Zn finger	188..208	CDD:275368	8/19 (42%)
		zf-H2C2_2	201..225	CDD:290200	12/23 (52%)
		C2H2 Zn finger	216..236	CDD:275368	7/19 (37%)
		zf-H2C2_2	228..252	CDD:290200	9/23 (39%)
		C2H2 Zn finger	244..264	CDD:275368	7/19 (37%)
		zf-H2C2_2	256..281	CDD:290200	8/25 (32%)
		C2H2 Zn finger	272..292	CDD:275368	2/9 (22%)
		zf-H2C2_2	285..307	CDD:290200
		C2H2 Zn finger	300..320	CDD:275368
		zf-H2C2_2	312..337	CDD:290200
		C2H2 Zn finger	328..348	CDD:275368
		zf-H2C2_2	341..365	CDD:290200
		C2H2 Zn finger	356..376	CDD:275368
		zf-H2C2_2	368..393	CDD:290200
		C2H2 Zn finger	384..404	CDD:275368
		C2H2 Zn finger	440..460	CDD:275368
		zf-H2C2_2	452..477	CDD:290200
		C2H2 Zn finger	468..488	CDD:275368
		zf-H2C2_2	481..505	CDD:290200
		C2H2 Zn finger	496..516	CDD:275368
		zf-H2C2_2	508..533	CDD:290200
		C2H2 Zn finger	524..544	CDD:275368
		zf-H2C2_2	537..561	CDD:290200
		C2H2 Zn finger	552..572	CDD:275368
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000