DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8159 and ZNF281

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_001268222.1	Gene:	ZNF281 / 23528	HGNCID:	13075	Length:	895	Species:	Homo sapiens

Alignment Length:	384	Identity:	83/384 - (21%)
Similarity:	143/384 - (37%)	Gaps:	89/384 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PGLPDWMCETCQTDLKSAISFRDRCLRSQKIFEESLVRNEEDTFRSSVRRSARSQRQRH------ 103
            |..||...:  :....||.:|..:  |:...|.:|||..:::.......:.:......|
Human    93 PPAPDMTFK--KEPAASAAAFPSQ--RTSWGFLQSLVSIKQEKPADPEEQQSHHHHHHHHYGGLF 153

  Fly   104 ---EDTAPKTPASPLEVMIKLESLSNGDEEDDGI--------DHLDSCNEADMELAIKAMSSSTE 157
               |:.:|              .|..|:....|:        .|:.. ..|.....:...|||..
Human   154 AGAEERSP--------------GLGGGEGGSHGVIQDLSILHQHVQQ-QPAQHHRDVLLSSSSRT 203

  Fly   158 DD--GTTSP---VRLKRTRR-----RGLKKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHLR 212
            ||  ||..|   ..:|:.:|     :|:|...|....:|   |....|..|..::...
Human   204 DDHHGTEEPKQDTNVKKAKRPKPESQGIKAKRKPSASSK---PSLVGDGEGAILSPSQ------- 258

  Fly   213 KHSGIRPFQCELCPARFLSSGELKGHQVMHTGDRKFQCRYCDRTYVNYSGRLRHERTHTNDRPFI 277
                 :|..|:.|.|.|.||..|:.|.::|||:|.|||..|...::......|||:.|:.::||.
Human   259 -----KPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKIHSREKPFG 318

  Fly   278 CAQCGKSFTNSYILKNHMLIHTGERLFRCELCHRSFARPTHLKTHFR----------------SN 326
            |.||...|...|.::.|...|:||:.::|:.|.:.|:|...|..|.|                |:
Human   319 CDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEVIVKGATSAEPGSS 383

  Fly   327 THKHNLEKSMADAGGVQLSPSQSADQVKFVTEKEPEA------------EADAFTIEVP 373
            .|.:....::...|....|..::..:...:..||.:.            ...::::|:|
Human   384 NHTNMGNLAVLSQGNTSSSRRKTKSKSIAIENKEQKTGKTNESQISNNINMQSYSVEMP 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	8/32 (25%)
		C2H2 Zn finger	194..214	CDD:275368	2/19 (11%)
		COG5048	<197..322	CDD:227381	38/124 (31%)
		zf-H2C2_2	206..231	CDD:290200	5/24 (21%)
		C2H2 Zn finger	222..242	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		zf-H2C2_2	265..287	CDD:290200	10/21 (48%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		zf-H2C2_2	291..315	CDD:290200	7/23 (30%)
		C2H2 Zn finger	306..328	CDD:275368	8/37 (22%)
ZNF281	NP_001268222.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..113		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..149		1/18 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..253		19/73 (26%)
		C2H2 Zn finger	263..283	CDD:275368	8/19 (42%)
		zf-H2C2_2	275..300	CDD:316026	10/24 (42%)
		C2H2 Zn finger	291..311	CDD:275368	5/19 (26%)
		zf-H2C2_2	304..328	CDD:316026	10/23 (43%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		zf-H2C2_2	331..356	CDD:316026	7/24 (29%)
		C2H2 Zn finger	347..366	CDD:275368	6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..427		6/49 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910