DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8159 and ZNF784

DIOPT Version :9

Sequence 1:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster
Sequence 2:	NP_976308.1	Gene:	ZNF784 / 147808	HGNCID:	33111	Length:	323	Species:	Homo sapiens

Alignment Length:	338	Identity:	93/338 - (27%)
Similarity:	136/338 - (40%)	Gaps:	73/338 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 RSSVRRSARSQRQRH-----EDTAPKTPASPL---EVMIKLESLSNGDEEDDGIDHLDSCNEADM 145
            |||....:|||....     :|..|.||.|.|   :|:...::....:..:.|..|...|
Human    11 RSSPTPESRSQEPLDLVLVPDDCRPGTPPSDLIEIQVVKVTDTTLVPEPPEPGSFHCALC----- 70

  Fly   146 ELAIKAMSSST-EDDGTTSPVRLKRTRRRGLKKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDR 209
            ..|.:.:|... .:.|..:          |.:.||:|.:.::       |..||::..|.:|...
Human    71 PAAFRLVSELLFHEHGHLA----------GAEGGGQGGDPSR-------CHVCGHSCPGPASLRA 118

  Fly   210 HLRKHSGIRPFQCELCPARFLSSGELKGHQVMHTGD----------------------------- 245
            |...|:|.||::|.|||..|.:...|..||..|..:
Human   119 HYSLHTGERPYRCALCPRAFKALAPLLRHQHRHGVEPGTSRRPPDTAAVAEQRPGVAPERAEVVM 183

  Fly   246 ----------RKFQCRYCDRTYVNYSGRLRHERTHTNDRPFICAQCGKSFTNSYILKNHMLIHTG 300
                      :.|.||:|.:.:...|....|||.||.:||:.|..|||.||.|.:|..|..||||
Human   184 AAAAAGAAVGKPFACRFCAKPFRRSSDMRDHERVHTGERPYHCGICGKGFTQSSVLSGHARIHTG 248

  Fly   301 ERLFRCELCHRSFARPTHLKTHFRSNTHKHNLEKSMADAGGVQLSPSQSADQVKFVTEKEPEAEA 365
            ||.|||.||.|:|...::.:.|.|  ||.|.....:.|:|| ||..|.:..........:|..|.
Human   249 ERPFRCTLCDRTFNNSSNFRKHQR--THFHGPGPGLGDSGG-QLGSSAAEGSGSGCGVGDPAEEG 310

  Fly   366 DAFTIEVPLPAEQ 378
            ...|.:|.:.|:|
Human   311 RGETAKVKVEADQ 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871
		C2H2 Zn finger	194..214	CDD:275368	6/19 (32%)
		COG5048	<197..322	CDD:227381	52/163 (32%)
		zf-H2C2_2	206..231	CDD:290200	11/24 (46%)
		C2H2 Zn finger	222..242	CDD:275368	8/19 (42%)
		C2H2 Zn finger	250..270	CDD:275368	7/19 (37%)
		zf-H2C2_2	265..287	CDD:290200	12/21 (57%)
		C2H2 Zn finger	278..298	CDD:275368	9/19 (47%)
		zf-H2C2_2	291..315	CDD:290200	15/23 (65%)
		C2H2 Zn finger	306..328	CDD:275368	7/21 (33%)
ZNF784	NP_976308.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		6/14 (43%)
		C2H2 Zn finger	67..87	CDD:275368	3/24 (13%)
		C2H2 Zn finger	103..123	CDD:275368	6/19 (32%)
		C2H2 Zn finger	131..151	CDD:275368	8/19 (42%)
		COG5048	<194..276	CDD:227381	38/83 (46%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		C2H2 Zn finger	226..246	CDD:275368	9/19 (47%)
		C2H2 Zn finger	254..274	CDD:275368	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..323		16/56 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4797
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050