DRSC/TRiP Functional Genomics Resources

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Protein Alignment nom and ZNF8

DIOPT Version :9

Sequence 1:NP_001262384.1 Gene:nom / 41038 FlyBaseID:FBgn0037617 Length:370 Species:Drosophila melanogaster
Sequence 2:NP_066575.2 Gene:ZNF8 / 7554 HGNCID:13154 Length:575 Species:Homo sapiens


Alignment Length:274 Identity:76/274 - (27%)
Similarity:115/274 - (41%) Gaps:35/274 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 VVTNESKASAGESVGGDEFDQPVEISNEPDATDSDVNLEEI------DLP---DEDGLESDHDLP 177
            :..:|..:|......|....||.|.|:....:...:.:.|:      |.|   .:.|...:|: .
Human   207 ITDSEHNSSLVSQQTGSPGKQPGENSDCHRDSSQAIPITELTKSQVQDKPYKCTDCGKSFNHN-A 270

  Fly   178 NVQIHK----------CDTCGIIKNNKSSLVRHQFEHNGIRPYPCKECPKTFLVASELKAHNLTH 232
            ::.:||          |..||...:..||||:|:..|.|.:||.|.||.|:|..::.|..|... 
Human   271 HLTVHKRIHTGERPYMCKECGKAFSQNSSLVQHERIHTGDKPYKCAECGKSFCHSTHLTVHRRI- 334

  Fly   233 HTLEPPFACRYCDRRYFSVVGRKKHERVHTNERPFVCDQCGKAFTRTCILKAHMAVHQVVRKYSC 297
            ||.|.|:.|:.|.|.:.......:|:|.||.|:|:.|..|||:|:||..|..|:..|...|.|.|
Human   335 HTGEKPYECQDCGRAFNQNSSLGRHKRTHTGEKPYTCSVCGKSFSRTTCLFLHLRTHTEERPYEC 399

  Fly   298 DVCDRSFSLKKHLATHFISNTHKRNAEAVTSSSEYMSMLSFE-----SDETWSQ--GTPLTTSID 355
            :.|.:.|.....||.|       :...|.....|....|.||     :...|::  |.....|.|
Human   400 NHCGKGFRHSSSLAQH-------QRKHAGEKPFECRQRLIFEQTPALTKHEWTEALGCDPPLSQD 457

  Fly   356 EDLVQSQFDLLCQE 369
            |...:|.....|.:
Human   458 ERTHRSDRPFKCNQ 471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nomNP_001262384.1 zf-AD 5..76 CDD:214871
C2H2 Zn finger 184..204 CDD:275368 8/19 (42%)
C2H2 Zn finger 212..261 CDD:275368 16/48 (33%)
zf-H2C2_2 255..278 CDD:290200 11/22 (50%)
C2H2 Zn finger 269..289 CDD:275368 9/19 (47%)
zf-H2C2_2 282..305 CDD:290200 7/22 (32%)
C2H2 Zn finger 297..313 CDD:275368 5/15 (33%)
ZNF8NP_066575.2 KRAB 25..85 CDD:214630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 92..130
COG5048 <167..404 CDD:227381 60/198 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..237 7/26 (27%)
C2H2 Zn finger 259..279 CDD:275368 4/20 (20%)
C2H2 Zn finger 287..307 CDD:275368 8/19 (42%)
C2H2 Zn finger 315..335 CDD:275368 7/20 (35%)
C2H2 Zn finger 343..363 CDD:275368 5/19 (26%)
C2H2 Zn finger 371..391 CDD:275368 9/19 (47%)
zf-C2H2 397..419 CDD:306579 7/28 (25%)
C2H2 Zn finger 399..419 CDD:275368 6/26 (23%)
zf-C2H2 467..489 CDD:306579 1/5 (20%)
C2H2 Zn finger 469..489 CDD:275368 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..533
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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