DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nom and M1BP

DIOPT Version :9

Sequence 1:	NP_001262384.1	Gene:	nom / 41038	FlyBaseID:	FBgn0037617	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	116/394 - (29%)
Similarity:	170/394 - (43%)	Gaps:	81/394 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LINVCRVCGRSRLCPKAVELFKPGRQDILRRIQLITGILLQQIPNAPDMVCFCCQTDLQSAMIFR 66
            |.:.||||.:.....::.:||:.....::..|:.:||:.|:.....||.:|.||..:|.||:..|
  Fly     9 LKSTCRVCAKYASNKRSPKLFERSNTKMIDNIEALTGLRLENYGCLPDQICECCSMELASAVKLR 73

  Fly    67 RQCILQQKK-WVPLLQSDKVGAS---------------------------------EEKKVEPND 97
            .:||..|:: .:.|.:..:.|.|                                 ||.|.|.:|
  Fly    74 ERCIAAQRELLLGLTEEQRQGISAFYRAAVMGEDIVQTVKTPDDDEVYATYQEIVLEEPKEEIDD 138

  Fly    98 PSTKKKTTKRRRGRPRMPLEIVDIVVTNESKASAGESVGGD-------EFDQPVEISNEPDATDS 155
            ...:...|.         .|:.:.....:..||..|....|       |..|.:|:..:.:....
  Fly   139 TKVEYDNTY---------YEVAEGHAGEDDAASLIEEADYDSIMAEDEEQQQTLELDEDTELIVG 194

  Fly   156 DVNLEEI-DLPDE-----DGLESDHDLPNVQIHK------------------------CDTCGII 190
            |||...: |..||     :.|:.:::..|:.:.|                        |:.||..
  Fly   195 DVNDAYVYDSDDEVAVLDNVLDDEYEHENIVVKKCSLPPKPKVRSDDARRRGTGGVYICEQCGNH 259

  Fly   191 KNNKSSLVRHQFEHNGIRPYPCKECPKTFLVASELKAHNLTHHTLEPPFACRYCDRRYFSVVGRK 255
            ...:.:...|...|.|.:.:.|:.|...|...||||.| :..||.|.||||:||.|.:.....|.
  Fly   260 IKGRMAFELHCRRHRGDKQFGCELCQSRFCTTSELKRH-MRKHTGERPFACKYCGRCFTDYTTRV 323

  Fly   256 KHERVHTNERPFVCDQCGKAFTRTCILKAHMAVHQVVRKYSCDVCDRSFSLKKHLATHFISNTHK 320
            ||||.||||||:||..||||||...|||.||.:|...|.|.|::||:||.|..||:|||.|..||
  Fly   324 KHERTHTNERPYVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTHFRSGVHK 388

  Fly   321 RNAE 324
            |:.|
  Fly   389 RHLE 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nom	NP_001262384.1	zf-AD	5..76	CDD:214871	22/71 (31%)
		C2H2 Zn finger	184..204	CDD:275368	4/19 (21%)
		C2H2 Zn finger	212..261	CDD:275368	23/48 (48%)
		zf-H2C2_2	255..278	CDD:290200	17/22 (77%)
		C2H2 Zn finger	269..289	CDD:275368	12/19 (63%)
		zf-H2C2_2	282..305	CDD:290200	11/22 (50%)
		C2H2 Zn finger	297..313	CDD:275368	8/15 (53%)
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	22/70 (31%)
		C2H2 Zn finger	253..273	CDD:275368	4/19 (21%)
		COG5048	276..>331	CDD:227381	24/55 (44%)
		C2H2 Zn finger	281..301	CDD:275368	8/20 (40%)
		zf-H2C2_2	293..317	CDD:290200	14/24 (58%)
		C2H2 Zn finger	309..329	CDD:275368	9/19 (47%)
		zf-H2C2_2	324..346	CDD:290200	17/21 (81%)
		C2H2 Zn finger	337..357	CDD:275368	12/19 (63%)
		zf-H2C2_2	350..372	CDD:290200	10/21 (48%)
		C2H2 Zn finger	365..383	CDD:275368	10/17 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447751
Domainoid	1	1.000	48	1.000	Domainoid score	I19075
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120097
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890