DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nom and Zif

DIOPT Version :9

Sequence 1:	NP_001262384.1	Gene:	nom / 41038	FlyBaseID:	FBgn0037617	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster

Alignment Length:	373	Identity:	89/373 - (23%)
Similarity:	154/373 - (41%)	Gaps:	63/373 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRVC-GRSRLCPKAVELFKPGRQDILRRIQLITGIL---LQQIPNAPDMVCFCCQTDLQSAMIFR 66
            |||| .:|....:..|:.:.|.:.....:..:.|:.   |....:.||.:|..|:.:|..|..||
  Fly    10 CRVCLAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAYQFR 74

  Fly    67 RQCILQQK------KWVPLL-QSDKVGASEEKKVEP---------NDPSTKKKTTKRRRGRPRMP 115
            .:.:.:|.      :.:.|| :||.:...||...:.         .:.:|.::..:..:|....
  Fly    75 EKALRKQMEIEEYCRELGLLDESDVMMIKEEDGSQQQCDEEMYILEETTTGEEEHQEEKGHEEY- 138

  Fly   116 LEIVDIVVTNESKASAGESVGGDEFDQPVEISNEPD--ATDSDVNLEEI---------------- 162
            ||    |.|::.:...|:::...|.:..:|::::..  ..:|:...||.
  Fly   139 LE----VDTSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLESEKQYEETPSQQLALQEAAKASLK 199

  Fly   163 -----------DLPDEDGLESDHDLPNVQIHKCDTCGIIKNNKSSLVRHQFEHNGIRPYPCKECP 216
                       .|...||.|...       :.||.||.....:..::.|:..|:||..|.|:.|.
  Fly   200 ARRGRVRRGLNSLTTSDGTEKGG-------YICDVCGNFYEKRGRMMEHRRRHDGICQYACELCD 257

  Fly   217 KTFLVASELKAHNLTHHTLEPPFACRYCDRRYFSVVGRKKHERVHTNERPFVCDQCGKAFTRTCI 281
            ..|.|..:|:.| :..||...|:.|.:|.|::|.....|.||.||...:|:||..|.|||.....
  Fly   258 AKFQVREQLRKH-MYSHTGSKPYKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHS 321

  Fly   282 LKAHMAVHQVVRKYSCDVCDRSFSLKKHLATHFISNTHKRNAEAVTSS 329
            |..|..:|..::.|.||.|::.|.|..|:..|..:..| :||..:..|
  Fly   322 LTKHELIHSDIKLYRCDYCNKDFRLLHHMRQHEETKLH-QNAVMLAES 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nom	NP_001262384.1	zf-AD	5..76	CDD:214871	18/79 (23%)
		C2H2 Zn finger	184..204	CDD:275368	5/19 (26%)
		C2H2 Zn finger	212..261	CDD:275368	16/48 (33%)
		zf-H2C2_2	255..278	CDD:290200	12/22 (55%)
		C2H2 Zn finger	269..289	CDD:275368	7/19 (37%)
		zf-H2C2_2	282..305	CDD:290200	7/22 (32%)
		C2H2 Zn finger	297..313	CDD:275368	6/15 (40%)
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	18/76 (24%)
		C2H2 Zn finger	225..245	CDD:275368	5/19 (26%)
		COG5048	<250..369	CDD:227381	41/121 (34%)
		C2H2 Zn finger	253..273	CDD:275368	6/20 (30%)
		zf-H2C2_2	266..288	CDD:290200	8/22 (36%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	294..318	CDD:290200	12/23 (52%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..353	CDD:275368	6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.960