Protein Alignment nom and ZNF281

DIOPT Version :9

• Sequence 1: NP_001262384.1
• Gene: nom / 41038
• FlyBaseID: FBgn0037617
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_001268222.1
• Gene: ZNF281 / 23528
• HGNCID: 13075
• Length: 895
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 88/391 - (22%)
• Similarity: 138/391 - (35%)
• Gaps: 105/391 - (26%)

  Fly    45 PNAPDMVCFCCQTDLQSAMIFRRQCILQQKKWVPLLQSDKVGASEEKKVEPNDPSTKKKTTKRRR 109
            |.||||.  ..:....||..|..    |:..| ..||| .|...:||..:|.:..:.........
Human    93 PPAPDMT--FKKEPAASAAAFPS----QRTSW-GFLQS-LVSIKQEKPADPEEQQSHHHHHHHHY 149

  Fly   110 G------RPRMP---------------LEIV-------------DIVVTNESKASAGESVGGDEF 140
            |      ..|.|               |.|:             |:::::.|:..  :..|.:|.
Human   150 GGLFAGAEERSPGLGGGEGGSHGVIQDLSILHQHVQQQPAQHHRDVLLSSSSRTD--DHHGTEEP 212

  Fly   141 DQPVEISNEPDATDSDVNLEEIDLPDEDGLESDHD------------------LPNVQIHKCDTC 187
            .|           |::|...:...|:..|:::...                  .|:.:.|.||.|
Human   213 KQ-----------DTNVKKAKRPKPESQGIKAKRKPSASSKPSLVGDGEGAILSPSQKPHICDHC 266

  Fly   188 GIIKNNKSSLVRHQFEHNGIRPYPCKECPKTFLVASELKAHNLTHHTLEPPFACRYCDRRYFSVV 252
            .....:...|.||...|.|.||:.|.:|...|:....|:.|... |:.|.||.|..|..::....
Human   267 SAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYLLQRHEKI-HSREKPFGCDQCSMKFIQKY 330

  Fly   253 GRKKHERVHTNERPFVCDQCGKAFTRT-CILKAHMAVHQVVRKYSCDV----------------- 299
            ..::|:|.|:.|:|:.||.|.:.|:|| .:||......:|:.|.:...
Human   331 HMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKHRRTCGEVIVKGATSAEPGSSNHTNMGNLAVLS 395

  Fly   300 -----CDRSFSLKKHLATHFISN----THKRNAEAVTSSSEYMSMLSFESDETWSQGTPLTTSID 355
                 ..|..:..|.:|   |.|    |.|.| |:..|::..|...|.|.....|.|..:.|.||
Human   396 QGNTSSSRRKTKSKSIA---IENKEQKTGKTN-ESQISNNINMQSYSVEMPTVSSSGGIIGTGID 456

  Fly   356 E 356
            |
Human   457 E 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nom	NP_001262384.1	zf-AD	5..76	CDD:214871	9/30 (30%)
		C2H2 Zn finger	184..204	CDD:275368	6/19 (32%)
		C2H2 Zn finger	212..261	CDD:275368	13/48 (27%)
		zf-H2C2_2	255..278	CDD:290200	9/22 (41%)
		C2H2 Zn finger	269..289	CDD:275368	8/20 (40%)
		zf-H2C2_2	282..305	CDD:290200	5/44 (11%)
		C2H2 Zn finger	297..313	CDD:275368	3/37 (8%)
ZNF281	NP_001268222.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..113		8/21 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..149		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..253		9/82 (11%)
		C2H2 Zn finger	263..283	CDD:275368	6/19 (32%)
		zf-H2C2_2	275..300	CDD:316026	10/24 (42%)
		C2H2 Zn finger	291..311	CDD:275368	5/20 (25%)
		zf-H2C2_2	304..328	CDD:316026	8/24 (33%)
		C2H2 Zn finger	319..339	CDD:275368	4/19 (21%)
		zf-H2C2_2	331..356	CDD:316026	9/24 (38%)
		C2H2 Zn finger	347..366	CDD:275368	8/18 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..427		9/53 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	778..817

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910