DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8112 and DGAT1

DIOPT Version :9

Sequence 1:	NP_731269.2	Gene:	CG8112 / 41033	FlyBaseID:	FBgn0037612	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_036211.2	Gene:	DGAT1 / 8694	HGNCID:	2843	Length:	488	Species:	Homo sapiens

Alignment Length:	540	Identity:	141/540 - (26%)
Similarity:	231/540 - (42%)	Gaps:	137/540 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DRKSTWHNRVTSQ-----------APADVSDSTNG---HANGTHPRPPIQSETSA-------RKQ 114
            ||.|:...|..|:           |..:|.|:..|   .|.|..|.|....:..|       ..:
Human     3 DRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELR 67

  Fly   115 RRQLPEKVFVARESYLTALLQVEHMRTIYHIFYIILV-----MFLLNVICYDYFVDGRFDLGLGT 174
            ..:|.:.:|.:...:       .:.|.|.:...::|:     :||.|:|.|...||
Human    68 CHRLQDSLFSSDSGF-------SNYRGILNWCVVMLILSNARLFLENLIKYGILVD--------- 116

  Fly   175 FRGGLRRLHWVMGVWLLEHVFVLALYFAFRGWALVRHKLK-PHSSLQRFWSHSCLILYISSQLVF 238
                              .:.|::|:            || |:|     |...||::..:...|.
Human   117 ------------------PIQVVSLF------------LKDPYS-----WPAPCLVIAANVFAVA 146

  Fly   239 CF-----------------------VSTSLCLKFNLPFVSACILLLES-----TRLLMKMHA--F 273
            .|                       ::|.||      |.:|.:||:||     :.|.:..|.  |
Human   147 AFQVEKRLAVGALTEQAGLLLHVANLATILC------FPAAVVLLVESITPVGSLLALMAHTILF 205

  Fly   274 VRYNAERVLN-----GKAKKEDAEEEKEGSERPFV---PPLSCYT---YFLFAPTLIYRDSYPRT 327
            ::..:.|.:|     .:||...|.::...:..|..   |....|.   ||||||||.|..::||:
Human   206 LKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRS 270

  Fly   328 SHIRWKFALNRLLEVVAIAFLYAFIHERHIHEHFGQYGLEP---MGPSQLILKLFGMMLPSAVIF 389
            ..||.:|.|.|:||::....|...:.::.:.... |..::|   |..|::|.:|..:.:|:.:|:
Human   271 PRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTI-QNSMKPFKDMDYSRIIERLLKLAVPNHLIW 334

  Fly   390 LCGFYLILHSWLNFTSELLRFGDRMFYKDWWTSHTYDGYYRNWNVVVHDWLYEYVYKDMYTHVFR 454
            |..||.:.||.||..:||::||||.||:|||.|.:...:::|||:.||.|...:.||.|   :.|
Human   335 LIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPM---LRR 396

  Fly   455 G-SKVAASLAVFMISAVVHEQVLGFALQMFFPVMFFFFGVVG-VALV-FLMRSAPKVMGNIFLWF 516
            | ||..|...||:.||..||.::...|:||  .::.|.|::. :.|. |:.|......||..:|.
Human   397 GSSKWMARTGVFLASAFFHEYLVSVPLRMF--RLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWL 459

  Fly   517 SLILGNATLISLYAMEHYAL 536
            |||:|....:.:|..::|.|
Human   460 SLIIGQPIAVLMYVHDYYVL 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8112	NP_731269.2	MBOAT	<231..473	CDD:294479	86/286 (30%)
DGAT1	NP_036211.2	Involved in homomerization. /evidence=ECO:0000250\|UniProtKB:Q9Z2A7	1..91		18/94 (19%)
		Disordered. /evidence=ECO:0000305\|PubMed:32433610	1..57		13/53 (25%)
		MBOAT	70..472	CDD:382173	124/464 (27%)
		Extracellular loop 1 (EL1). /evidence=ECO:0000269\|PubMed:32433610	119..130		5/22 (23%)
		MBOAT fold. /evidence=ECO:0000269\|PubMed:32433610	131..488		109/361 (30%)
		Intracellular loop 1 (IL1). /evidence=ECO:0000269\|PubMed:32433610	224..276		18/51 (35%)
		Intracellular loop 2 (IL2). /evidence=ECO:0000269\|PubMed:32433610	354..399		21/47 (45%)
		FYXDWWN motif. /evidence=ECO:0000303\|PubMed:32433610	360..366		4/5 (80%)
		Acyl-CoA binding. /evidence=ECO:0000269\|PubMed:32433610, ECO:0000269\|PubMed:32433611, ECO:0007744\|PDB:6VP0, ECO:0007744\|PDB:6VYI, ECO:0007744\|PDB:6VZ1	374..382		3/7 (43%)
		Amphipathic helix (AH). /evidence=ECO:0000269\|PubMed:32433610	380..394		6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275897at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2034
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950