DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8112 and Soat1

DIOPT Version :9

Sequence 1:	NP_731269.2	Gene:	CG8112 / 41033	FlyBaseID:	FBgn0037612	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_112380.1	Gene:	Soat1 / 81782	RGDID:	621641	Length:	545	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	206/566 - (36%)
Similarity:	285/566 - (50%)	Gaps:	49/566 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AAERQEKRGEEETQPRLPDL---GFVRDKLQKFQSKMLTDFEQRLSCMVEDVLQDLRQRELRAHE 63
            :||..|   ::|.|..|.|.   |.:       ..|.|...:::|:...|: |:.|..:|:..|
  Rat    15 SAENPE---QDEAQKNLLDTHRNGHI-------TMKQLIAKKRQLAAEAEE-LKPLFLKEVGCH- 67

  Fly    64 FPNFERSDRKSTWHNRVTSQAPADVSDSTNGHANGTHPRPPIQSETSARKQRRQLPE--KVFVAR 126
            |.:|            ||:......|....|.|..|.............|..|..||  |:|::|
  Rat    68 FDDF------------VTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR 120

  Fly   127 ESYLTALLQVEHMRTIYHIFYIILVMFLLNVICYDYFVDGRFDLGLGTFRGGLRRLHWVMGVWLL 191
            .|.|..|.:|:|:|||||:|..:|::|:|:.:..||..:||..|..........:...|:..|..
  Rat   121 RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWA 185

  Fly   192 EHVFVLAL-YFAFRGWALVRHKLKPHSSLQRFWS--HSCLILYISSQL-VFCFVSTSLCLKFNLP 252
            ..:..||: ||.|:.||....|    ||....:|  |....|..  || :..|:.|.:.|.:.||
  Rat   186 MFLSTLAIPYFLFQRWAHGYSK----SSHPLIYSLIHGAFFLVF--QLGILGFIPTYVVLAYTLP 244

  Fly   253 FVSACILLLESTRLLMKMHAFVRYNAERVLNGKAKKEDAEEEKEGSERPFVPPLSCYTYFLFAPT 317
            ..|..||:||..||:||.|::||.|..|||:.         .||.|....||.::.|.|||||||
  Rat   245 PASRFILILEQIRLVMKAHSYVRENVPRVLSA---------AKEKSSTVPVPTVNQYLYFLFAPT 300

  Fly   318 LIYRDSYPRTSHIRWKFALNRLLEVVAIAFLYAFIHERHIHEHFGQYGLEPMGPSQLILKLFGMM 382
            ||||||||||..:||.:...:.|:|....|...:|.||.....|.....||.....|:|.:|..:
  Rat   301 LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSI 365

  Fly   383 LPSAVIFLCGFYLILHSWLNFTSELLRFGDRMFYKDWWTSHTYDGYYRNWNVVVHDWLYEYVYKD 447
            ||..::....|:..||.|||..:|:|||||||||||||.|.:|..|||.||||||||||.|||||
  Rat   366 LPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKD 430

  Fly   448 MYTHVFRGSKVAASLAVFMISAVVHEQVLGFALQMFFPVMFFFFGVVGVALVFLMR-SAPKVMGN 511
            :.....:..:.||.||||.:||||||..|...|..|:||:|..|...|:|..|::. |..:.:.|
  Rat   431 LLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWN 495

  Fly   512 IFLWFSLILGNATLISLYAMEHYALKNCNLSNESWTYRLLPAVWRC 557
            |.:..||.||:..::..|:.|.||.:.|.|.|.::...:.|..|.|
  Rat   496 IMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTC 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8112	NP_731269.2	MBOAT	<231..473	CDD:294479	112/242 (46%)
Soat1	NP_112380.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		3/11 (27%)
		MBOAT	166..515	CDD:281107	147/363 (40%)
		FYXDWWN motif. /evidence=ECO:0000250\|UniProtKB:P35610	398..404		5/5 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354186
Domainoid	1	1.000	249	1.000	Domainoid score	I2061
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2333
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2476
OMA	1	1.010	-	-		QHG55030
OrthoDB	1	1.010	-	-		D1275897at2759
OrthoFinder	1	1.000	-	-		FOG0003079
OrthoInspector	1	1.000	-	-		otm45114
orthoMCL	1	0.900	-	-		OOG6_105870
Panther	1	1.100	-	-	O	PTHR10408
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1556
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910