DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8112 and Soat2

DIOPT Version :9

Sequence 1:	NP_731269.2	Gene:	CG8112 / 41033	FlyBaseID:	FBgn0037612	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_666176.1	Gene:	Soat2 / 223920	MGIID:	1332226	Length:	525	Species:	Mus musculus

Alignment Length:	576	Identity:	183/576 - (31%)
Similarity:	269/576 - (46%)	Gaps:	88/576 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ERQEK--RGEEETQPR--LPDLGFVRDKLQKFQSKMLTDFEQRLSCMVEDVLQDLRQRELRAHEF 64
            |.|||  ||.|.....  .|||......::..:::.|...::.|:.:::..|.:..|.
Mouse    16 EEQEKGARGGEGNARTHGTPDLVQWTRHMEAVKTQFLEQAQRELAELLDRALWEAMQA------- 73

  Fly    65 PNFERSDRKSTWHNRVTSQAPADVSDSTNGHANGTHPRPPIQSETSARKQRRQLPEKVFVARESY 129
              :.:.||.      :.|.||    |||: .....||.                ..|||:.|:|.
Mouse    74 --YPKQDRP------LPSAAP----DSTS-KTQELHPG----------------KRKVFITRKSL 109

  Fly   130 LTALLQVEHMRTIYHIFYIILVMFLLNVICYDYFVDGR----FDLGLGTFRGGLRRLHWVMGVWL 190
            :..|::|:|.|||||:|...|.:.:::.:..|:..:||    |||.|.:|    .:|...:..|:
Mouse   110 IDELMEVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSF----GQLPLALMTWV 170

  Fly   191 LEHVFVLALYFAFRG---WALVRHKLKPHSSLQRFW----SHSCLILYISSQLVFCFVSTSLCLK 248
              .:|:..|...::.   ||      :|.:.  ..|    |..|::| .:..:|.|.:...:.::
Mouse   171 --PMFLSTLLVPYQTLWLWA------RPRAG--GAWMLGASLGCVLL-AAHAVVLCVLPVHVSVR 224

  Fly   249 FNLPFVSACILLLESTRLLMKMHAFVRYNAERVL---NGKAKKEDAEEEKEGSERPFVPPLSCYT 310
            ..||..|.|:|:.|..|||||.::|:|.....:.   .||....              |..|.|.
Mouse   225 HELPPASRCVLVFEQVRLLMKSYSFLRETVPGIFCVRGGKGISP--------------PSFSSYL 275

  Fly   311 YFLFAPTLIYRDSYPRTSHIRWKFALNRLLEVVAIAFLYAFIHERHIHEHFGQYGLEPMGPSQLI 375
            ||||.||||||::||||..|||.:......:|:.......||..|.....|.....||.....|:
Mouse   276 YFLFCPTLIYRETYPRTPSIRWNYVAKNFAQVLGCLLYACFILGRLCVPVFANMSREPFSTRALL 340

  Fly   376 LKLFGMMLPSAVIFLCGFYLILHSWLNFTSELLRFGDRMFYKDWWTSHTYDGYYRNWNVVVHDWL 440
            |.:.....|...:.|..|:..||.|||..:|:|||||||||:|||.|.::..|||.|||||||||
Mouse   341 LSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWL 405

  Fly   441 YEYVYKDMYTHVFRGSKVAASLAVFMISAVVHEQVLGFALQMFFPVMFFFFGVVGVALVFLM--- 502
            |.|||:|....:.|.::..|.|.||::||||||.:..|.|..|:|||...|.|.|..|.|.|
Mouse   406 YSYVYQDGLWLLGRRARGVAMLGVFLVSAVVHEYIFCFVLGFFYPVMLMLFLVFGGLLNFTMNDR 470

  Fly   503 RSAPKVMGNIFLWFSLILGNATLISLYAMEHYALKNCNLSNESWTYRLLPAVWRCY 558
            .:.|  ..||.:|..|.:|....:|||..|.||.::|.|...::...:.|..|.|:
Mouse   471 HTGP--AWNILMWTFLFMGQGIQVSLYCQEWYARRHCPLPQTTFWGMVTPRSWSCH 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8112	NP_731269.2	MBOAT	<231..473	CDD:294479	94/244 (39%)
Soat2	NP_666176.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..97		8/30 (27%)
		MBOAT	<263..497	CDD:281107	102/249 (41%)
		FYXDWWN motif. /evidence=ECO:0000250\|UniProtKB:P35610	380..386		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850491
Domainoid	1	1.000	261	1.000	Domainoid score	I1949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	329	1.000	Inparanoid score	I2433
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55030
OrthoDB	1	1.010	-	-		D1275897at2759
OrthoFinder	1	1.000	-	-		FOG0003079
OrthoInspector	1	1.000	-	-		otm43051
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10408
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2034
SonicParanoid	1	1.000	-	-		X1556
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.040