DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hb and ZNF518B

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001362745.1	Gene:	ZNF518B / 85460	HGNCID:	29365	Length:	1074	Species:	Homo sapiens

Alignment Length:	805	Identity:	158/805 - (19%)
Similarity:	236/805 - (29%)	Gaps:	318/805 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 HLMGGFNPLTPPGLPNPMQHFYGGNLRPSPQPTPT-----SASTIAPVAVATGSSEKLQALTPPM 181
            ||.||.|.||    .:|.|....|..||:.|...|     |.:..|.:.:||
Human    12 HLNGGHNSLT----MSPKQPDANGAPRPNRQEAQTLLYQGSEAEAAMMTIAT------------- 59

  Fly   182 DVTPPKSPAKSSQSNIEPEKEHDQM------------------SNSSEDMKYMAESEDDDTNIRM 228
             ....||..|.|..:::.....|.|                  ||:|.......::|:..:::
Human    60 -CAKCKSVHKISLQDLQKGTGKDGMYVCFQCSLGAAPPNFHFVSNNSSATHVGNKTENFSSSV-- 121

  Fly   229 PIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEY--HIRKH 291
               ||..|::|:                       ||.| ..|.||.|.|  |..|:|  |..:|
Human   122 ---NSKFKVRNF-----------------------KPGK-YYCDKCRFST--KDPLQYKKHTLQH 157

  Fly   292 KNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYA---TKYC--HSFKLHLRKYGHKP 351
            :..| |.|..|||....|.....|...|:.::.|:|..|||.   ..|.  |:.::|.|....:|
Human   158 EEIK-FICSHCSYISYTKGEFQRHLVKHTGIFPYQCEYCDYGAIRNDYIVKHTKRVHERAGAKRP 221

  Fly   352 GMVL-----DEDGT--PNPSLVIDVYGTRRGPKSKNGGPIASGGSGSG----------------- 392
            ...:     ...||  .||.|:     ....|::......:...||..
Human   222 VKAVAKLEPKRTGTSKQNPELL-----KASNPRTTFQNKWSDQLSGFSLHANKDKMHNIMLLPEP 281

  Fly   393 --------------------------SRKSNVAAVAPQQQQSQPAQP---VATSQL--------- 419
                                      ::...|..::|.::..||..|   ||.::|
Human   282 KEYQKDVVCIPNKMTLSEPNEVNLFENKNVEVEVLSPAKEPVQPGMPLTVVAPAELVVPANCLAQ 346

  Fly   420 -----------SAALQGFPLVQGN-------SAPPAASPVLPLPASPAKSVASVEQTPSLPSPAN 466
                       ...|:.|||.:.|       :...:...|....::..:.|.|.|:|.||....|
Human   347 LIDVKVVNGTQQLVLKLFPLEENNCLEAGRDNGGNSERMVKEKGSNEQEKVLSAEKTKSLTVDGN 411

  Fly   467 L----------------------------LPPLASL---------------LQQNRNM----AFF 484
            :                            :.|.:|:               .|:..|:    ..|
Human   412 VGKLVGIDSFQPSVQKQLKNVKWVRSYDFIMPNSSVHNNGKSFINSETIEDFQKKNNLYPHRTAF 476

  Fly   485 P------------YWNLNLQMLAAQQ-----QAAVLAQLSPRMREQLQQQ--------------- 517
            |            :.|..|:.|.|..     :|||....|.|......||
Human   477 PSVALKGHSLASVFKNSVLRSLGAASNPFPYKAAVCFAESGRNLHSSSQQLLPFAASPATCSFSG 541

  Fly   518 ---------------------------NQQQSDNEEEEQDDEYERKSVDSAMDLSQGTPVK---- 551
                                       |::|.||:.|      |.|:|.:...:|.....:
Human   542 EKGLLPVSENDLESTSKVNIPVKVVSSNRKQEDNQTE------EHKAVSTVGQISSQHKSEYLHI 600

  Fly   552 ----EDEQQQQPQQPLAMNLKVEEEAT-----PLMSSSNASRRKGRVLKLDTLLQLRSEAMTSPE 607
                ||..||...:||  .||..|...     |::||               :..|.|.:...||
Human   601 NITGEDRSQQPGDKPL--ELKNSERTNNTNDGPVISS---------------VFSLSSGSENVPE 648

  Fly   608 QLKVPSTPMPTASSPIAGRK-PMPEEHCSGTSS-ADESMETAHVPQANTSASSTASSSGNSSNAS 670
            .:|..|:.....|..:..|| ....|.|...|| |..|.....|.||:...|...|......|.|
Human   649 GIKWNSSTSKIKSIELLRRKIAQLIESCGKPSSLASNSAHRRSVGQASKGTSKATSEGIQEINVS 713

  Fly   671 SNSNGNSSSNSSSNGTTSAVAAPPS 695
            ....|:|         |..:..||:
Human   714 LTGLGHS---------TGTLQKPPN 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	0/19 (0%)
		C2H2 Zn finger	271..291	CDD:275368	9/21 (43%)
		zf-H2C2_2	283..308	CDD:290200	10/26 (38%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..345	CDD:275368	7/22 (32%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZNF518B	NP_001362745.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..36		11/27 (41%)
		C2H2 Zn finger	137..157	CDD:275368	9/21 (43%)
		zf-H2C2_5	164..186	CDD:372805	7/21 (33%)
		C2H2 Zn finger	164..184	CDD:275368	6/19 (32%)
		C2H2 Zn finger	192..213	CDD:275368	6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..590		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..632		9/30 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	678..704		8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930