DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hb and Rest

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_113976.2	Gene:	Rest / 83618	RGDID:	621069	Length:	1069	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	180/978 - (18%)
Similarity:	278/978 - (28%)	Gaps:	407/978 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PPGLPN------------PMQHF--------YGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQA 176
            |.||.|            |...|        |..|..|:|:         ||||     .:|.:.
  Rat   102 PSGLDNMELRSLELSVVEPQPVFEASAAPEVYSSNKDPAPE---------APVA-----EDKCKN 152

  Fly   177 L-TPPMDVTPPKSPAKSSQSNIEPEKEHDQ----MSNSSEDMKYMAE-----SEDDD-------- 223
            | ..|....|.:..|:|.:..:...:.|..    :..|:|......|     ||:.:
  Rat   153 LKAKPFRCKPCQYEAESEEQFVHHIRVHSAKKFFVEESAEKQAKARESGASPSEEGEFSKGPIRC 217

  Fly   224 ------TNIRMPIYNSHGK--------MKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPK- 273
                  || |...|.:|.|        .:.|||..|....:::..:..|.|.|. |.|:..|.|
  Rat   218 DRCGYNTN-RYDHYTAHLKHHLRAGDNERVYKCIICTYTTVSEYHWRKHLRNHF-PRKVYTCSKC 280

  Fly   274 ---------------------------CPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSM 311
                                       ||:.:..|.||..|:|.|..:|||:||:|:|...|:..
  Rat   281 NYFSDRKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHE 345

  Fly   312 LNSH-RKSHSSVYQYRCADCDYATKYCHSFKLHLR-----------------------KYGHK-- 350
            :..| |:.|:......|..|||.|....:||.|:.                       :|..|
  Rat   346 VTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSK 410

  Fly   351 ----PGMVLD------------------------------------------------------- 356
                |...:|
  Rat   411 HPTCPSKTMDVSKVKLKKTKRREADLHRDAAAAATEQTDTEQAKTKGVDASARRSERPVKGVGKD 475

  Fly   357 --EDGTP--NPSLVIDVYGTRRGPKSKNG--GPIASGGSGSGSRKSNVAAVAPQQQQSQ---PAQ 412
              ::..|  |.|:|.....||:.......  |....|.:|:.:.||:.|..:.::..::   .|:
  Rat   476 VPKEKKPCSNASVVQVTTRTRKSAVETKAAEGKHTDGQTGNNAEKSSKAKKSKRKMDAEAHPSAE 540

  Fly   413 PV-------------------------------ATSQLSAALQ---------------------- 424
            ||                               |..|.||:::
  Rat   541 PVTEGPVTKKKKTESKPKTSGEVPKGSRVEDRKADKQQSASIKKGGKKTALKTKTAKKGSKLAPK 605

  Fly   425 -------GFPLVQGNSAP-PA----------------ASPV---------------------LPL 444
                   ...:.||..:| ||                :||:                     .||
  Rat   606 GVGHTEPSSEMAQGGESPVPALTQAVVTPSGSTQTELSSPMDIAQTEPAQMDVSQTGPPQVQRPL 670

  Fly   445 PASPAK------------------------------SVASVEQTPSL-PS----PANLLPPLASL 474
            |..||:                              ..|.:|.:|.: ||    |.:|.|||...
  Rat   671 PVEPAQLEPSPPQEPPQVEPPACVEPPPPVEPPCPMEPAEMEPSPPMEPSQVEPPPHLEPPLPME 735

  Fly   475 LQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSD--------NEEEEQDD 531
            |.|   :...|..:...::.:.:.....:||..|.....:|::....|:        .....:|.
  Rat   736 LPQ---VELPPVEDCQKELPSVEHAQTKVAQTGPTQVGAVQEEPLSVSEPPQVKLTRRSSPRKDR 797

  Fly   532 EYERKSVDSAMDLSQG-------TPVKEDE---------QQQQPQQPLAMNLKVEEEATPL---M 577
            ..|:.||.|.|...:.       .||::.:         ....|..||... .:..|.||.   |
  Rat   798 AKEKLSVLSEMARQEQVLIEVGLVPVRDSQLLKASKSAPDLPAPPSPLPKG-HLRREETPKDQEM 861

  Fly   578 SSSNASRRKGRVLKLDTLLQLRSEAMTSPEQLKVPSTPMPTASSPIAGRKPMPE---EHCSGTSS 639
            .|.....:...:.|..|     .||..|..:|..|.......||..:...|..|   ..|...|:
  Rat   862 FSDGEGNKVSPLEKGGT-----EEAGESRAELAAPMESTSALSSEQSSNAPDGETLHSECQADST 921

  Fly   640 A------DESMETAHV--------------PQANTSASSTA----------------SSSGNSSN 668
            |      |...:|..|              |:.:..|::.|                ...|..|:
  Rat   922 AVCEMEVDTEQKTDRVPLKDSAVEPVSPLNPRVDPEAAAPAVVASPPITLAESQEIDEDEGIHSH 986

  Fly   669 ASSNSNGNSSSNSSSNGTTSAVAAP-----PSGTPAAAGAIYE----CKYCDIFFKDAVLYTIHM 724
            ..|:.:.|.|..|..:|...|..||     .||....|..:.|    |.:||..|:....|:.|:
  Rat   987 DGSDLSDNMSEGSDDSGLHGARPAPQEATSKSGKEGLAVKVTEGEFVCIFCDRSFRKEKDYSKHL 1051

  Fly   725 GYH 727
            ..|
  Rat  1052 NRH 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	271..291	CDD:275368	9/47 (19%)
		zf-H2C2_2	283..308	CDD:290200	12/24 (50%)
		C2H2 Zn finger	299..319	CDD:275368	7/20 (35%)
		C2H2 Zn finger	327..345	CDD:275368	8/17 (47%)
		C2H2 Zn finger	707..727	CDD:275371	6/19 (32%)
		C2H2 Zn finger	735..757	CDD:275371
Rest	NP_113976.2	C2H2 Zn finger	249..269	CDD:275368	4/19 (21%)
		COG5048	<270..413	CDD:227381	33/143 (23%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		zf-H2C2_2	289..314	CDD:404364	2/24 (8%)
		zf-H2C2_5	303..327	CDD:404746	8/23 (35%)
		C2H2 Zn finger	305..325	CDD:275368	7/19 (37%)
		zf-H2C2_2	317..342	CDD:404364	12/24 (50%)
		C2H2 Zn finger	333..351	CDD:275368	6/17 (35%)
		C2H2 Zn finger	390..406	CDD:275368	0/15 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350857
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264318at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940