DRSC/TRiP Functional Genomics Resources

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Protein Alignment hb and ZNF202

DIOPT Version :9

Sequence 1:NP_731267.1 Gene:hb / 41032 FlyBaseID:FBgn0001180 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_001288708.1 Gene:ZNF202 / 7753 HGNCID:12994 Length:648 Species:Homo sapiens


Alignment Length:540 Identity:99/540 - (18%)
Similarity:152/540 - (28%) Gaps:240/540 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 ASSPRQSPIPSTNHLEQFLKQQ----QQQLQQQPMDTLCAMTPSPSQN---DQNSLQHYDANLQQ 98
            |:|||::.|.......|:|:.:    :|.|:...::....:.|...|:   .|......:|....
Human    57 AASPREALIRLRELCHQWLRPERRTKEQILELLVLEQFLTVLPGELQSWVRGQRPESGEEAVTLV 121

  Fly    99 QLLQQQQYQQ------HFQAAQQQHHHHHHLMGGFNPLTPPGLPNPMQHFYGGNLRPSPQPTPTS 157
            :.||:|..:.      |....:.......||  |..|.:|..|.:|:|   ......||:.|..|
Human   122 EGLQKQPRRPRRWVTVHVHGQEVLSEETVHL--GVEPESPNELQDPVQ---SSTPEQSPEETTQS 181

  Fly   158 ASTIAPVAVATGSSEKLQALTPPMDVTP--PKSPAKSSQ-------------------------- 194
            ....||........|:||.|.......|  |..||:.|.                          
Human   182 PDLGAPAEQRPHQEEELQTLQESEVPVPEDPDLPAERSSGDSEMVALLTALSQGLVTFKDVAVCF 246

  Fly   195 -----SNIEP-EKEH-----------------------DQMS----------------------- 207
                 |:::| :||.                       |::|                       
Human   247 SQDQWSDLDPTQKEFYGEYVLEEDCGIVVSLSFPIPRPDEISQVREEEPWVPDIQEPQETQEPEI 311

  Fly   208 -------NSSEDMKYMAESED--------------------------DD-----------TNIRM 228
                   :.|:|.:...|.||                          :|           |||..
Human   312 LSFTYTGDRSKDEEECLEQEDLSLEDIHRPVLGEPEIHQTPDWEIVFEDNPGRLNERRFGTNISQ 376

  Fly   229 -----------PIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHM--KPDKILQCPK------- 273
                       |::...|  :::.|..||...........|.|||.  ||.|.::|.|       
Human   377 VNSFVNLRETTPVHPLLG--RHHDCSVCGKSFTCNSHLVRHLRTHTGEKPYKCMECGKSYTRSSH 439

  Fly   274 -----------CPF--------------VTEF----------------KH-----HLEYHIRKHK 292
                       .|:              ||:.                ||     .|..|.|.|.
Human   440 LARHQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKPYRCDDCGKHFRWTSDLVRHQRTHT 504

  Fly   293 NQKPFQCDKCSYTCVNKSMLN----------------------------SHRKSHSSVYQYRCAD 329
            .:|||.|..|..:...||:|.                            :|||:|::...|.|::
Human   505 GEKPFFCTICGKSFSQKSVLTTHQRIHLGGKPYLCGECGEDFSEHRRYLAHRKTHAAEELYLCSE 569

  Fly   330 CDYATKYCHSFKLHLRKYGH 349
            |.....:..:|..|||  ||
Human   570 CGRCFTHSAAFAKHLR--GH 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbNP_731267.1 C2H2 Zn finger 242..262 CDD:275368 5/19 (26%)
C2H2 Zn finger 271..291 CDD:275368 10/72 (14%)
zf-H2C2_2 283..308 CDD:290200 9/24 (38%)
C2H2 Zn finger 299..319 CDD:275368 8/47 (17%)
C2H2 Zn finger 327..345 CDD:275368 4/17 (24%)
C2H2 Zn finger 707..727 CDD:275371
C2H2 Zn finger 735..757 CDD:275371
ZNF202NP_001288708.1 SCAN 43..153 CDD:128708 19/97 (20%)
SCAN 43..130 CDD:280241 16/72 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..221 23/79 (29%)
KRAB 237..297 CDD:214630 6/59 (10%)
KRAB 237..277 CDD:279668 4/39 (10%)
COG5048 397..>644 CDD:227381 42/193 (22%)
C2H2 Zn finger 399..419 CDD:275368 5/19 (26%)
zf-H2C2_2 411..436 CDD:290200 9/24 (38%)
C2H2 Zn finger 427..447 CDD:275368 2/19 (11%)
C2H2 Zn finger 483..503 CDD:275368 5/19 (26%)
zf-H2C2_2 495..520 CDD:290200 9/24 (38%)
C2H2 Zn finger 511..531 CDD:275368 5/19 (26%)
C2H2 Zn finger 539..559 CDD:275368 3/19 (16%)
C2H2 Zn finger 567..587 CDD:275368 6/21 (29%)
zf-C2H2 593..615 CDD:278523
C2H2 Zn finger 595..615 CDD:275368
zf-H2C2_2 607..632 CDD:290200
C2H2 Zn finger 623..643 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156893
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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