DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and ZNF174

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001334797.1	Gene:	ZNF174 / 7727	HGNCID:	12963	Length:	407	Species:	Homo sapiens

Alignment Length:	423	Identity:	83/423 - (19%)
Similarity:	144/423 - (34%)	Gaps:	116/423 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TTATTNYEQHNAWYNSMFAANIKQEPGHHLDGNSVASSP---RQS-----------PIPSTNHLE 56
            |.|::..|:|       ..|.::::.|..|..|  ...|   |||           |..:.:.|.
Human    13 TEASSKQERH-------IIAKLEEKRGPPLQKN--CPDPELCRQSFRRFCYQEVSGPQEALSQLR 68

  Fly    57 QFLKQ--------QQQQLQQQPMDTLCAMTP------------------------------SPS- 82
            |..:|        ::|.|:...|:....:.|                              .|.
Human    69 QLCRQWLQPELHTKEQILELLVMEQFLTILPPEIQARVRHRCPMSSKEIVTLVEDFHRASKKPKQ 133

  Fly    83 ------QNDQNSLQHYDANLQQQLLQQQQYQQHFQAAQQQHHHHHHLMGGFNPLTPPGLPNPMQH 141
                  |..:..|:...:.|.:|.|...|.|...:..::.........|.::.|:|        |
Human   134 WVAVCMQGQKVLLEKTGSQLGEQELPDFQPQTPRRDLRESSPAEPSQAGAYDRLSP--------H 190

  Fly   142 FYGGNLRPSP---QPTPTSASTIAPVAVATGSSEKLQAL----TPPMDVTPPKSPAKSSQSNIEP 199
            .:    ..||   :|||..|.|.|| .:.:.:.|..|..    ..|..|:..:|.....| |.||
Human   191 HW----EKSPLLQEPTPKLAGTEAP-RMRSDNKENPQQEGAKGAKPCAVSAGRSKGNGLQ-NPEP 249

  Fly   200 EKEHDQMSNSSEDMKYMAESEDDDTNIRMPI--YNSHGK------------MKNYKCKTCGVVAI 250
                 :.:|.||..  ::..:....|.:.|.  |..|.:            ::..|....|..::
Human   250 -----RGANMSEPR--LSRRQVSSPNAQKPFAHYQRHCRVEYISSPLKSHPLRELKKSKGGKRSL 307

  Fly   251 T-KVDFWAH--TRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSML 312
            : ::....|  ||:..||.|   |..|.....:...|:.|.|.|..::|:.|.:|......:|.|
Human   308 SNRLQHLGHQPTRSAKKPYK---CDDCGKSFTWNSELKRHKRVHTGERPYTCGECGNCFGRQSTL 369

  Fly   313 NSHRKSHSSVYQYRCADCDYATKYCHSFKLHLR 345
            ..|::.|:....|:|..|..:.:...:...|.|
Human   370 KLHQRIHTGEKPYQCGQCGKSFRQSSNLHQHHR 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	4/22 (18%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		zf-H2C2_2	283..308	CDD:290200	7/24 (29%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..345	CDD:275368	3/17 (18%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZNF174	NP_001334797.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		2/6 (33%)
ZNF174	NP_001334797.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..270		31/140 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930