DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and ZNF131

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001284477.1	Gene:	ZNF131 / 7690	HGNCID:	12915	Length:	623	Species:	Homo sapiens

Alignment Length:	468	Identity:	88/468 - (18%)
Similarity:	156/468 - (33%)	Gaps:	128/468 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ATGSSEKLQALTPPMDVTP----------------PKSPAKSSQSNIE---------PEKEHDQM 206
            :||||:. .||....|:|.                |..|.......||         .:..|.:.
Human   202 STGSSDD-SALALLADITSKYRQGDRKGQIKEDGCPSDPTSKQVEGIEIVELQLSHVKDLFHCEK 265

  Fly   207 SNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRT-HMKP----- 265
            .|.|..:.|..:..          ..|| ..:::||:.|....:.:..:..|... |::.
Human   266 CNRSFKLFYHFKEH----------MKSH-STESFKCEICNKRYLRESAWKQHLNCYHLEEGGVSK 319

  Fly   266 -----DKILQCPKCPFVTEFKH--HLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSH-------- 315
                 .||..|..|.  .:|.|  |.:.|:|||..:|||:|..|.......|.|..|
Human   320 KQRTGKKIHVCQYCE--KQFDHFGHFKEHLRKHTGEKPFECPNCHERFARNSTLKCHLTACQTGV 382

  Fly   316 --RKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVLDEDGTPNPSLVIDVYGTRRGPKS 378
              :|....:|:  |..|:........||.||         |:.....||...:.|::..:.....
Human   383 GAKKGRKKLYE--CQVCNSVFNSWDQFKDHL---------VIHTGDKPNHCTLCDLWFMQGNELR 436

  Fly   379 KNGGPIASGGSGSGSRKSNVAAVAPQQQ-QSQPAQPVATSQLSAALQGFPL--VQGNSAPPAASP 440
            ::    .|.......|......::.:.: |::|...:...:....:...||  ||.:||.
Human   437 RH----LSDAHNISERLVTEEVLSVETRVQTEPVTSMTIIEQVGKVHVLPLLQVQVDSAQ----- 492

  Fly   441 VLPLPASPAKSVASVEQT-PSLPSPANLLPPLASLLQQNRNMAFFPYWNL--------------- 489
                        .:|||. |.|...:.:.....|.|.:...:::.....:
Human   493 ------------VTVEQVHPDLLQDSQVHDSHMSELPEQVQVSYLEVGRIQTEEGTEVHVEELHV 545

  Fly   490 ---NLQMLAAQQQ--AAVLAQLSPRMREQLQQQNQQ----QSDNEEEEQDDEYERK-SVDSAMDL 544
               |...:..|.:  .|.|..::|.:..|.::::.|    ::..|:.|..::.|.| :|||..:.
Human   546 ERVNQMPVEVQTELLEADLDHVTPEIMNQEERESSQADAAEAAREDHEDAEDLETKPTVDSEAEK 610

  Fly   545 SQ-----GTPVKE 552
            ::     ..||.|
Human   611 AENEDRTALPVLE 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	3/20 (15%)
		C2H2 Zn finger	271..291	CDD:275368	7/21 (33%)
		zf-H2C2_2	283..308	CDD:290200	10/24 (42%)
		C2H2 Zn finger	299..319	CDD:275368	6/29 (21%)
		C2H2 Zn finger	327..345	CDD:275368	5/17 (29%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZNF131	NP_001284477.1	BTB	24..122	CDD:279045
		BTB	35..122	CDD:197585
		Nuclear localization signal 1. /evidence=ECO:0000269\|PubMed:17306895	137..148
		COG5048	<262..444	CDD:227381	43/209 (21%)
		C2H2 Zn finger	263..283	CDD:275368	3/29 (10%)
		C2H2 Zn finger	290..311	CDD:275368	3/20 (15%)
		Nuclear localization signal 2. /evidence=ECO:0000269\|PubMed:17306895	317..328		1/10 (10%)
		C2H2 Zn finger	330..350	CDD:275368	7/21 (33%)
		zf-H2C2_2	342..367	CDD:290200	10/24 (42%)
		C2H2 Zn finger	358..375	CDD:275368	4/16 (25%)
		C2H2 Zn finger	394..414	CDD:275368	7/28 (25%)
		C2H2 Zn finger	422..439	CDD:275370	1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	573..623		11/49 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930