DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hb and ZNF18

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001290210.1	Gene:	ZNF18 / 7566	HGNCID:	12969	Length:	549	Species:	Homo sapiens

Alignment Length:	314	Identity:	73/314 - (23%)
Similarity:	113/314 - (35%)	Gaps:	89/314 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 PSPS------QNDQNSL---QHYDANLQQQLLQ---QQQYQQHFQAAQQQHHHHHHLMGGFNPLT 131
            |.|:      :||:.:|   .|.|    |:||.   |...:...||:          :.||....
Human   282 PRPTCIGDRQENDKENLNLENHRD----QELLHASCQASGEVPSQAS----------LRGFFTED 332

  Fly   132 PPG-------LPNPMQHFY--GGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPPMDVTPPK 187
            .||       ||..:|:..  |...:.|||..               .|||......|
Human   333 EPGCFGEGENLPEALQNIQDEGTGEQLSPQER---------------ISEKQLGQHLP------- 375

  Fly   188 SPAKSSQSNIEPEKEHDQMSNSSEDMKYMAESEDDDTNIRMPIYNSHGK--MKN----------- 239
            :|.....|.:..| |..:.|...:....||:        ::|.....||  .:|
Human   376 NPHSGEMSTMWLE-EKRETSQKGQPRAPMAQ--------KLPTCRECGKTFYRNSQLIFHQRTHT 431

  Fly   240 ----YKCKTCGVVAITKVDFWAHTRTHM--KPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQ 298
                ::|..|....:...||..|.|||.  ||.|...|.|  ..::|. .|.:|.:.|..:||::
Human   432 GETYFQCTICKKAFLRSSDFVKHQRTHTGEKPCKCDYCGK--GFSDFS-GLRHHEKIHTGEKPYK 493

  Fly   299 CDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKY-GHKP 351
            |..|..:.:.:|..|.|::.|:....|:|:.|..:..:..|...|.|.: |.||
Human   494 CPICEKSFIQRSNFNRHQRVHTGEKPYKCSHCGKSFSWSSSLDKHQRSHLGKKP 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		zf-H2C2_2	283..308	CDD:290200	7/24 (29%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..345	CDD:275368	4/17 (24%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZNF18	NP_001290210.1	SCAN	37..148	CDD:322011
		KRAB	<222..249	CDD:307490
		C2H2 Zn finger	410..430	CDD:275368	3/19 (16%)
		COG5048	<436..549	CDD:227381	34/115 (30%)
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
		C2H2 Zn finger	466..486	CDD:275368	5/22 (23%)
		zf-H2C2_2	479..503	CDD:316026	7/23 (30%)
		C2H2 Zn finger	494..514	CDD:275368	5/19 (26%)
		zf-H2C2_2	506..530	CDD:316026	6/23 (26%)
		C2H2 Zn finger	522..542	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930