Protein Alignment hb and rest

DIOPT Version :10

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_031759548.1
• Gene: rest / 734016
• XenbaseID: XB-GENE-955466
• Length: 1453
• Species: Xenopus tropicalis
• Alignment Length: 696
• Identity: 134/696 - (19%)
• Similarity: 234/696 - (33%)
• Gaps: 201/696 - (28%)

  Fly   187 KSPAKSSQSNIEPE---------------------------KEHDQMSNSSEDMK-----YMAES 219
            |:..|.|.|||..|                           |.|::...:....|     |...|
 Frog   241 KTQGKESDSNIPEESDISKGPIQCDRCGYNTNRFDHYLAHLKHHNKAGENERVYKCTICTYTTVS 305

  Fly   220 EDDDTNIRMPIYNSHGKMKN------YKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVT 278
            |          |:....::|      |.|..|...:..|.::..|.||| ..::..||..||:.:
 Frog   306 E----------YHWKKHLRNHYPRILYTCSQCSYFSDRKNNYIQHIRTH-TGERPYQCIICPYSS 359

  Fly   279 EFKHHLEYHIRKHKNQKPFQCDKCSY----------------------TC-------VNKSMLNS 314
            ..|.||..|:|.|..:|||:|::|||                      ||       .::|....
 Frog   360 SQKTHLTRHMRTHSGEKPFKCEQCSYVASNQHEVTRHARQVHNGPKPLTCPHCDYKTADRSNFKK 424

  Fly   315 HRKSHSSVYQYRCADCDY-ATKYC---------HS---------FKLHLRKYGHKPGMVLDED-- 358
            |.:.|.:..|:.|..||| |:|.|         ||         .|:.||....:.| |.|.|
 Frog   425 HVELHVNPRQFLCPVCDYAASKKCNLQYHIKSRHSGCTNITMDVSKVKLRTKKGEVG-VADTDTN 488

  Fly   359 -GTPNPSLV-------IDVYGTRRGPKSKN---GGPIASGGSGSGSRKSNVAAVAPQQQQSQ-PA 411
             .|.|.:::       :......|..|||.   .|.:|        :||.:::...:.:.|: .|
 Frog   489 KQTENGNIIKKKLEETVKAEKKERCVKSKKRMIDGQVA--------KKSRLSSTQKKIKASEVRA 545

  Fly   412 QPVATSQLSAALQGFPLVQGNSAPPAASPV--LPLPASPAKSVASVEQTPSLPSPANLLPPLASL 474
            :.:...:.|:.::....:..|.:....|.|  ..|..|||..|.:.|....:|.      .:..|
 Frog   546 EKIEKFRKSSCVKRKADLLENPSDTLTSTVKKKKLKNSPASKVITSEIKDDIPK------KVKGL 604

  Fly   475 LQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSDNEEEEQDDEYERKSVD 539
            :::..|.|                           ::.:.:::...||.|.:.....:...:.||
 Frog   605 VKKKENSA---------------------------VKSKHKKKTGAQSSNGKRNMPKKITEQKVD 642

  Fly   540 SAMDLSQGTPVKEDEQQQQPQQPLAMNLKVEE-EATPLMSSSN--ASRRKGRV-------LKLDT 594
            ....|....||..|.::|.....:|.....|: .||.:.|.:|  ::...|.:       |.::|
 Frog   643 KGNKLDSKIPVAPDIEEQMIVGKVANENDSEQFVATDIASINNNLSTESCGLLNEVVHTDLSINT 707

  Fly   595 LLQLRSEAMTSPEQLKVPSTPMPTASSPIAGRKPMPEEHCSGTSSADESMETAHVPQANTSASST 659
            .|:.:..|.:..:...|....:..|         |..:..:|.|..:::.:...:.....|....
 Frog   708 TLETKLSAGSESKSEHVSKAIIELA---------MQVDVKAGISKQEKTQDNYLMDIETISTDLE 763

  Fly   660 ASSSGNSSNASSNSNGNSSSN---SSSNGTTSAVAAPPSG-------TPAAAGAIYECK------ 708
            ..:.....|......||:.::   .|:..|.....:.|:.       .|.....:.|||
 Frog   764 KPNQVLLQNGIPPKKGNTIADLLVDSAKTTVYLQISKPTSCLLKDCCQPNKKLQVGECKPTCYVP 828

  Fly   709 --YCDI-------FFKDAVLYTIHMGYHSCDDVFKC--NMCGEKCD 743
              .|:.       ....:..:.:..|..|||....|  ::||:..|
 Frog   829 MELCETSADLPLEHGDPSATHLVSRGTPSCDHPVNCGESLCGQHVD 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	8/19 (42%)
		zf-H2C2_2	283..308	CDD:463886	14/53 (26%)
		C2H2 Zn finger	299..319	CDD:275368	8/48 (17%)
		C2H2 Zn finger	327..345	CDD:275368	10/36 (28%)
		C2H2 Zn finger	707..727	CDD:275371	4/34 (12%)
		C2H2 Zn finger	735..757	CDD:275371	4/11 (36%)
rest	XP_031759548.1	zf-H2C2_5	322..346	CDD:404746	8/24 (33%)
		C2H2 Zn finger	324..344	CDD:275368	5/19 (26%)
		zf-H2C2_2	336..361	CDD:463886	8/25 (32%)
		C2H2 Zn finger	352..372	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..389	CDD:463886	12/24 (50%)
		C2H2 Zn finger	380..398	CDD:275368	4/17 (24%)
		C2H2 Zn finger	409..429	CDD:275368	3/19 (16%)
		zf-H2C2_5	409..429	CDD:404746	3/19 (16%)
		C2H2 Zn finger	437..458	CDD:275368	7/20 (35%)
		PTZ00121	<498..>639	CDD:173412	27/181 (15%)
		PHA03307	850..>1185	CDD:223039	8/25 (32%)
		Drf_FH1	913..>1025	CDD:461881