Protein Alignment hb and Zfp518a

DIOPT Version :10

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_082595.1
• Gene: Zfp518a / 72672
• MGIID: 1919922
• Length: 1478
• Species: Mus musculus
• Alignment Length: 730
• Identity: 141/730 - (19%)
• Similarity: 234/730 - (32%)
• Gaps: 252/730 - (34%)

  Fly   158 ASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKSSQSNIEPE--KEHD------------QMSN 208
            |.||..|:.:..|....|.:...:::..||       .||..|  .:|:            |.:.
Mouse    27 ADTIRSVSTSKISETSFQYVLKDVNICLPK-------INIPNEILMKHEVEKYRLLFQSKPQTAR 84

  Fly   209 SSEDMKYMA------------ESEDDDTNIRMPIYN------------------------SHGKM 237
            .|..:|.::            .:||:..|:...|.|                        .||::
Mouse    85 KSISVKTVSCAEECVLLCKSERAEDETVNMSAKILNFSCSKCQDSTQYSPNDLQKHFEMWHHGEL 149

  Fly   238 KNYKCKTCGVVAITKVDFWAHTRTH----MKPDKI------------------------LQCPKC 274
            .::.|:.|...|.....|..|.:||    :|.|..                        .||.:|
Mouse   150 PSFPCEMCSFSASDFQIFKQHRKTHRNTFVKCDICNSERSYTLLDLTKHFTSKHCVNGNFQCEEC 214

  Fly   275 PFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKY--- 336
            .|.|:.......||.:|| :..::|.||.:.|..|..|..|.:.||....:.|..|.|...:
Mouse   215 RFFTQDVGTFVQHIHRHK-EVHYKCGKCHHLCFTKGELQKHLRVHSGTLPFTCHYCSYGAIHKDQ 278

  Fly   337 --CHSFKLHLRKYGHKPGMVLDE-------DGTPNPSLVIDVYGTRRGP-----KSKNGGPIASG 387
              .|...||......|..:..|:       ..|....|::..|  :.||     |.|.   |.||
Mouse   279 LIRHVITLHKEHLYAKEKLERDQYDKRVAKTTTTGLKLILKRY--KIGPTKTFWKRKT---ITSG 338

  Fly   388 GS---GSGSRKSNVAAVA---------------------------PQQQQSQPAQPVATSQLSAA 422
            ..   |..::..|:.:..                           |.:.:|:.|..::|.|.:.|
Mouse   339 NDESIGKNAQAFNIVSKTQTKSEDQSQEQVNGEKGEKQHCENGDKPVESESEKATVLSTGQYNKA 403

  Fly   423 LQG--------FPLVQGNSAPPAASPVLPLPASPAKSVASVEQTPS--------LPSPANLLPPL 471
            .:|        ...|||.:.....:..:.:||:.:......:....        ||:...:||
Mouse   404 DEGASTTSSSVLSAVQGPTVLLVRNNKITIPANYSAKFMGFKMVDGRQHIVIKLLPANKQILP-- 466

  Fly   472 ASLLQQN--RNMAFFPYWNLNLQMLAAQ---------------QQAAVLAQLSPRMREQLQQQNQ 519
            :.:||.|  :|...    ||:.|.:|..               .:||..|..||.:..::..:.:
Mouse   467 SPVLQSNTEKNSTA----NLSPQAVANTGFATGLTTKVNDTDFVKAAPPACSSPVLARKVISEKE 527

  Fly   520 ----QQSDNEEEEQDDEYERKSVDSAMDLSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMSSS 580
                .:.:|..:..||.....|:.:....|.....|.:.:.         |:.:.|..:| .|..
Mouse   528 AAFISEKNNTLQMVDDSKSLSSLPTTSTTSVRVTTKVEARD---------NVDLWENDSP-QSHP 582

  Fly   581 NASRRKGRVLKLDTLLQLRSEAMTSPEQLKVPSTPMPTASSPIAG----------RKPMPEEHCS 635
            :||         ||       :::||:  ||..||.|.|.|  :|          ...:|.|..:
Mouse   583 DAS---------DT-------SISSPD--KVSLTPKPNAYS--SGDMHNYCINYVNSELPAESSN 627

  Fly   636 GTSSADESMETAH-----------------------------VPQANTSASSTASSSGNSSNASS 671
            ....:::.....|                             |.|.:||.|.|||..  ....||
Mouse   628 SFEFSNQGSLPFHNYSKVNNKRRRFSRATLCENLQKESPNKTVTQQSTSDSDTASPL--LRKESS 690

  Fly   672 NSNGNSSSNSSSNGT 686
            ||:...:|.:..|||
Mouse   691 NSDNLFASINPLNGT 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:463886	8/24 (33%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..345	CDD:275368	6/22 (27%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
Zfp518a	NP_082595.1	C2H2 Zn finger	181..203	CDD:275368	1/21 (5%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	238..258	CDD:275368	7/19 (37%)
		zf-H2C2_2	250..271	CDD:463886	6/20 (30%)
		C2H2 Zn finger	266..283	CDD:275368	3/16 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..393		2/36 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	569..603		15/52 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..696		12/39 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1282..1305