Protein Alignment hb and Zfp131

DIOPT Version :10

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001289476.1
• Gene: Zfp131 / 72465
• MGIID: 1919715
• Length: 619
• Species: Mus musculus
• Alignment Length: 1026
• Identity: 197/1026 - (19%)
• Similarity: 321/1026 - (31%)
• Gaps: 391/1026 - (38%)

  Fly  2234 YVPTLIHFHV-----------LNKDINAGSIRL--PI----IGEDSELVSA-----GISSFGVSG 2276
            |...:..|||           ||.....|.:|.  ||    ..|.|.::.|     |....|...
Mouse    61 YAGEICGFHVQGLSAPFEAVLLNGTSGEGRLRARGPIDCERHREFSFIIQAHDCGTGPQGHGQKR 125

  Fly  2277 TNAAA--IAFNDNNKLEPYIPIHKYY-----------ILPISAKNQISLDNLEKQILSVIPLTDV 2328
            ::.||  :...|.|:..|.....:|:           ||.:.|.:|.......:
Mouse   126 SHKAAVRVQVGDVNEFSPVFGQLEYHGSVTEGKVYDSILQVQASDQDCSPQYSQ----------- 179

  Fly  2329 PICNIA-----SALANNRSHFTIRNALIVSNSGIVNSKMEGKPHRVAKKDRYHVKLCDSLLDASL 2388
             |||..     :|.|.:|:. .|||...:|               ..||..|.::
Mouse   180 -ICNYQITSPDTAFAVDRNG-NIRNTESLS---------------FEKKSHYKIR---------- 217

  Fly  2389 LQYDVINETYTVASLKNPQSFAMKFAIIKFLTSLSEYIEIVASDGEELLAVLLANGSLKWENFNK 2453
                       |.:|...|..||:.||:..      :::.:...|              |:.:.|
Mouse   218 -----------VTALDCGQKRAMQEAIVHI------HVKPICKPG--------------WQGWRK 251

  Fly  2454 TM-IELPIGSLLTEFADHDLNSTTSSSIKSYQTQPE------SHNLDSPMELMKL-------IMK 2504
            .: .|...||.|. |....| .|...|:...:|..|      ....||...|.||       ...
Mouse   252 LVDYEPGAGSKLL-FPKMHL-ETCEGSVSWIRTTVELETSGVGRGCDSERSLQKLCGSSSGSTAL 314

  Fly  2505 LYITGYDVDWATVYSPVEQFIALPNYQFNKQTLWFEERLEIVDHYLIGTIDEESEDTLILKNQIS 2569
            |..||...:|..                                            ||:
Mouse   315 LPATGGVCNWTV--------------------------------------------TLV------ 329

  Fly  2570 ELRHPQFFKGKPLDVGTMSEIAI-----EALKIRN-EIPFSIQNLKTELITLTKPAWL------- 2621
                        .|.|..|::|.     :|.||.: .:|   ||| |:..|:|  .|:
Mouse   330 ------------RDSGRDSDLAYRFDGHQAAKIPDWVVP---QNL-TDQFTIT--TWMKHGPSPG 376

  Fly  2622 -----ETNVTRNEDDE--GFNVSAYIDGQRL-FSLNASSVEIQNIEVPA-----VEVQIPDKV-- 2671
                 ||.:..::..|  ..:.|.|:...|| |.|.....:..:.. ||     :| ||.||.
Mouse   377 QRAEKETLLCNSDKTEMNRHHYSLYVHNCRLVFLLRTDYTQTDSFR-PAEFHWKLE-QICDKEWH 439

  Fly  2672 VYLKECPNAVIRRHRNMVYVDSRAEQSPFRTANIVLNEIIGFAPTPSDMFIEILGVLPSVHYMVQ 2736
            .|:......|:     .:|||. ....|:    :|.::                ..:.|....||
Mouse   440 YYVLSVDFPVV-----TLYVDG-VTYEPY----LVTDD----------------WPIHSSQIDVQ 478

  Fly  2737 VDDGALWQFQMISQDKRVLSNIYVLKDAKGLEIPTIRMHKKSTLLSSQEASIVAAKTLQMAVRHK 2801
            :..||.||...:|:.|   .:.|......||   |||..|    :.||:  |::
Mouse   479 LTVGACWQGGEVSKAK---FSQYFRGSLSGL---TIRPGK----IESQK--IIS----------- 520

  Fly  2802 VCLAVGDVIESGLDIDESQLSTGFSELG------------IDSLATVDL---------LNRLNQK 2845
             ||   ...:.||||      |....||            :..:...||         ::.:|.:
Mouse   521 -CL---QACKEGLDI------TSLENLGQRIKFHLNPAQSVLVMEAEDLEQMNGALRKVSYINSR 575

  Fly  2846 YFP-----EIELTTS-DLFDNP---SIIDLSIMIEQLLNEKGITEPSEPNTPKTSLRGRKLSIP- 2900
            .||     .:.::|: ..|...   |:.|:.:::.       :.:|||.....|.  ...|:||
Mouse   576 QFPTMGSRHLRISTAVQCFGEDVCISVPDIEVVVM-------VMQPSEARITITG--AEHLTIPA 631

  Fly  2901 ---AVRAQVLAQIEFVENYNSKQKEVQAEAPSSSSECSNHLEESDATVDRTEIRRKVSLAVFDLA 2962
               |:...:...:..:.....:.|....:..||:.|.:::|:..|..|...|:|  ..|...:|.
Mouse   632 YDLALGLSLFRDLHIISTVTKRDKVTNMDHRSSAKETAHNLDYCDILVLGEELR--AGLESLELH 694

  Fly  2963 TETLSAEDLQ----SKGFTELGMDSLS---------------IVDFV-------NRLNDKYFPDD 3001
            ...|..:.|:    |.|.:..|:||:|               .||.|       :.||.:|..|.
Mouse   695 HSALLGKHLEYANSSTGMSIYGVDSISHYTEVIRQVRYQSRRAVDSVRTFRLTCSELNGRYTSDQ 759

  Fly  3002 EITASDIFDYPTVDELSDHIVRKKSSSVPPAASEIMKET-----------MNGISTSV------- 3048
            .....:|.......|..:|::      .||.:.:|...|           :..:||||
Mouse   760 YTLQVNILHSEEAREHVNHLM------TPPKSMQITHRTVMESNNYFNLVVPAVSTSVVVVCIAA 818

  Fly  3049 ---------DAEHTKLENLSQSFMLLENQ-----NSINPTLKMIWSNQTIK 3085
                     ....|:.::..|:..|.|.|     :|::.|:..:.:.|.::
Mouse   819 LLVVLLGVYQLNQTQNKDSIQTHTLAEEQVDCEGSSLSITVNPLQNCQELQ 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368
		C2H2 Zn finger	271..291	CDD:275368
		zf-H2C2_2	283..308	CDD:463886
		C2H2 Zn finger	299..319	CDD:275368
		C2H2 Zn finger	327..345	CDD:275368
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
Zfp131	NP_001289476.1	BTB_POZ_ZBTB35_ZNF131	16..128	CDD:349530	15/66 (23%)
		Nuclear localization signal 1. /evidence=ECO:0000250	137..148		3/10 (30%)
		COG5048	<262..444	CDD:227381	50/253 (20%)
		C2H2 Zn finger	263..283	CDD:275368	5/21 (24%)
		C2H2 Zn finger	290..311	CDD:275368	5/20 (25%)
		Nuclear localization signal 2. /evidence=ECO:0000250	317..328		3/54 (6%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..367	CDD:463886	10/30 (33%)
		C2H2 Zn finger	358..375	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	422..439	CDD:275370	7/18 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..619		9/51 (18%)