DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and Ikzf5

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_780324.2	Gene:	Ikzf5 / 67143	MGIID:	1914393	Length:	419	Species:	Mus musculus

Alignment Length:	609	Identity:	138/609 - (22%)
Similarity:	205/609 - (33%)	Gaps:	229/609 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 PMDVTPPKSPAKSSQSNIEPEKEHDQMSNSSEDMKYMAES-----EDDDTN------IRMPIYNS 233
            |:|.      .|..|..:..:..|..|.:.|......||:     .|.|.|      :.:.:..:
Mouse     8 PLDF------VKDFQEYLTQQTHHVNMISGSVSGDKEAETLQGAGTDGDQNGLDHPSVEVSLDEN 66

  Fly   234 HGKMKN---------YKCKTCGVVAITKVDFWAHTRTHM--KPDKILQCPKCPFVTEFKHHLEYH 287
            .|.:.:         .||:.|...:........|.|.|.  ||.:   |..|||.:.::.|||.|
Mouse    67 SGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHR---CHLCPFASAYERHLEAH 128

  Fly   288 IRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPG 352
            :|.|..:||::|:.||:.|.::|.|:.||:                           ||  ||
Mouse   129 MRSHTGEKPYKCELCSFRCSDRSNLSHHRR---------------------------RK--HK-- 162

  Fly   353 MVLDEDGTPNPSLVIDVYGTRRGPKSKN-GGPIASGGSGSG-SRKSNVAAVAPQQQQSQPAQPVA 415
                         ::.:.|||....||. .|.:....|..| ||::.:....|.....:|
Mouse   163 -------------MVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKP----- 209

  Fly   416 TSQLSAALQGFPLVQGNS--APPAASPVLPLPASPAKSVASVEQTPSLPSPANLLPPLASLLQQN 478
             ..|:......|.:|.:|  |....:|...||..|        |...:.:|.|
Mouse   210 -DYLNDFTHEIPNIQTDSYEAMAKTTPTGGLPRDP--------QELMVDNPLN------------ 253

  Fly   479 RNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSDNEEEEQDDEYERKSVDSAMD 543
                       .|..||.|     |:.|.|      :.||....|              ||:.
Mouse   254 -----------QLSTLAGQ-----LSSLPP------ENQNPASPD--------------VDAC-- 280

  Fly   544 LSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMSSSNASRRKGRVLKLDTLLQLRSEAMTSPEQ 608
                    .||:....|||         .|..::|:.:||..             :|.:.||||
Mouse   281 --------PDEKPFMIQQP---------SAQAVVSAVSASIP-------------QSSSPTSPE- 314

  Fly   609 LKVPSTPMPTAS----SPIAGRKPMPEEHCSGTSSADESMETAHVPQANTSASSTASSSGNSSNA 669
                  |.|:.|    ||:||                        |.:..||.::..|.||
Mouse   315 ------PRPSHSQRNYSPVAG------------------------PSSEPSAHTSTPSIGN---- 345

  Fly   670 SSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAAGAIYECKYCDIFFKDAVLYTIHMGYHSCDDVFK 734
                     |..|:...|..|..|.        .::.|::||::|.|.||||:|||.|..|..|:
Mouse   346 ---------SQPSTPAPTLPVQDPQ--------LLHHCQHCDVYFADNVLYTVHMGCHGYDSPFQ 393

  Fly   735 CNMCGEKCDGPVGLFVHMARNAHS 758
            ||:||.||........|.||..|:
Mouse   394 CNVCGCKCKDKYDFACHFARGQHN 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	271..291	CDD:275368	9/19 (47%)
		zf-H2C2_2	283..308	CDD:290200	12/24 (50%)
		C2H2 Zn finger	299..319	CDD:275368	8/19 (42%)
		C2H2 Zn finger	327..345	CDD:275368	0/17 (0%)
		C2H2 Zn finger	707..727	CDD:275371	12/19 (63%)
		C2H2 Zn finger	735..757	CDD:275371	9/21 (43%)
Ikzf5	NP_780324.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..55		5/18 (28%)
		C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		zf-H2C2_2	96..121	CDD:404364	9/27 (33%)
		C2H2 Zn finger	112..132	CDD:275368	9/19 (47%)
		zf-H2C2_2	124..148	CDD:404364	11/23 (48%)
		C2H2 Zn finger	140..158	CDD:275368	7/17 (41%)
		fibronec_FbpA	<216..>352	CDD:411474	52/267 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..284		9/51 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..356		24/115 (21%)
		C2H2 Zn finger	366..393	CDD:275371	14/26 (54%)
		C2H2 Zn finger	394..416	CDD:275371	9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I4441
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264318at33208
OrthoFinder	1	1.000	-	-		FOG0003075
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.060