DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and plagx

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001034918.1	Gene:	plagx / 664689	ZFINID:	ZDB-GENE-030131-839	Length:	380	Species:	Danio rerio

Alignment Length:	395	Identity:	88/395 - (22%)
Similarity:	130/395 - (32%)	Gaps:	129/395 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 HGK-------------MKNYKCKTCGVVAITKVDFWAHTRTH-MKPDKILQCPKCPFVTEFKHHL 284
            |||             .:..:|:.||....|::....|..|| ......|.|..|..|.|....|
Zfish     3 HGKDQLNGHLQTHDPNKQELRCEECGKHYNTRLGLRRHVATHATSASSDLTCKVCRQVFESMPAL 67

  Fly   285 EYHIRKHKNQKP---------FQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADC-------DYA 333
            ..|:..|..:.|         .||::|......:..:..|...|:....:.|..|       |:.
Zfish    68 LEHLSTHTGRPPPGTVVRERKHQCERCGRRFFTRKDVRRHAVVHTGRRDFLCPRCAQRFGRRDHL 132

  Fly   334 TKYCHSFKLHLRKYGHKPGMVLDEDGTP------NPSLVIDVYG----TRRGPKSKNGGPIASGG 388
            |:  |..|.|.::....|.:.:.|:.:|      :|..|.:.:.    ..:|.:|.:...::...
Zfish   133 TR--HLKKSHAQELDALPTLPIKEEPSPTMCSVGSPKDVTEAFPMAMFNSQGLQSASTSGVSHHH 195

  Fly   389 SG--SGSRKSNVA--------AVAPQQQQSQPA-QPVA-TSQLSAALQGF-------PL------ 428
            .|  ||...|.|.        ...|||.|..|. ||.: ||.|.|.::.|       |:
Zfish   196 HGMVSGPLSSPVGMGCYLEPNKPPPQQYQQTPRYQPSSTTSYLKAEMENFLTELQCGPMPPQAAV 260

  Fly   429 --------------VQGNSA-------------PPAASPVLPL------------PASPAKSVAS 454
                          :.|.||             |||:|..:.|            |.|.....::
Zfish   261 ATAVSRPGDLLPESLGGQSAHFTLRNSAFTSAEPPASSANMDLSHLLGFLPFGLPPYSTPLGYST 325

  Fly   455 VEQTPSL-PSPANLLP-PLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLS------PRMR 511
            ....|:: |||.:.|. ||.|         |.|      |.|...|.|..|.|||      ||..
Zfish   326 TSAAPAVSPSPTSQLSGPLTS---------FQP------QSLHEPQAAGHLNQLSGFSPTLPRFH 375

  Fly   512 EQLQQ 516
            :..||
Zfish   376 QAFQQ 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:290200	7/33 (21%)
		C2H2 Zn finger	299..319	CDD:275368	3/19 (16%)
		C2H2 Zn finger	327..345	CDD:275368	7/24 (29%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
plagx	NP_001034918.1	C2H2 Zn finger	54..74	CDD:275368	6/19 (32%)
		C2H2 Zn finger	91..111	CDD:275368	3/19 (16%)
		C2H2 Zn finger	119..137	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930