DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and IKZF5

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001258769.1	Gene:	IKZF5 / 64376	HGNCID:	14283	Length:	419	Species:	Homo sapiens

Alignment Length:	619	Identity:	137/619 - (22%)
Similarity:	205/619 - (33%)	Gaps:	249/619 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 PMDVTPPKSPAKSSQSNIEPEKEHDQMSNSSEDMKYMAES-----EDDDTN------IRMPIYNS 233
            |:|.      .|..|..:..:..|..|.:.|......||:     .|.|.|      :.:.:..:
Human     8 PLDF------VKDFQEYLTQQTHHVNMISGSVSGDKEAEALQGAGTDGDQNGLDHPSVEVSLDEN 66

  Fly   234 HGKMKN---------YKCKTCGVVAITKVDFWAHTRTHM--KPDKILQCPKCPFVTEFKHHLEYH 287
            .|.:.:         .||:.|...:........|.|.|.  ||.:   |..|||.:.::.|||.|
Human    67 SGMLVDGFERTFDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHR---CHLCPFASAYERHLEAH 128

  Fly   288 IRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPG 352
            :|.|..:||::|:.||:.|.::|.|:.||:                           ||  ||
Human   129 MRSHTGEKPYKCELCSFRCSDRSNLSHHRR---------------------------RK--HK-- 162

  Fly   353 MVLDEDGTPNPSLVIDVYGTRRGPKSKN-GGPIASGGSGSG-SRKSNVAAVAPQQQQSQPAQPVA 415
                         ::.:.|||....||. .|.:....|..| ||::.:....|.....:|
Human   163 -------------MVPIKGTRSSLSSKKMWGVLQKKTSNLGYSRRALINLSPPSMVVQKP----- 209

  Fly   416 TSQLSAALQGFPLVQGNSAPPAA--SPVLPLPASPAKSVASVEQTPSLPSPANLLPPLA----SL 474
             ..|:......|.:|.:|....|  :|...||..|        |...:.:|.|.|..||    ||
Human   210 -DYLNDFTHEIPNIQTDSYESMAKTTPTGGLPRDP--------QELMVDNPLNQLSTLAGQLSSL 265

  Fly   475 LQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSDNEEEEQDDEYERKSVD 539
            ..:|:|.|                        ||.:
Human   266 PPENQNPA------------------------SPDV----------------------------- 277

  Fly   540 SAMDLSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMSSSNASRRKGRVLKLDTLLQLRSEAMT 604
                    .|. .||:....|||         ....::|:.:||..             :|.:.|
Human   278 --------VPC-PDEKPFMIQQP---------STQAVVSAVSASIP-------------QSSSPT 311

  Fly   605 SPEQLKVPSTPMPTAS----SPIAGRKPMPEEHCSGTSSADESMETAHVPQANTSASSTASSSGN 665
            |||       |.|:.|    ||:||                        |.:..||.::..|.||
Human   312 SPE-------PRPSHSQRNYSPVAG------------------------PSSEPSAHTSTPSIGN 345

  Fly   666 SSNASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAA------GAIYECKYCDIFFKDAVLYTIHM 724
            |.                          || |||.|      ..::.|::||::|.|.:||||||
Human   346 SQ--------------------------PS-TPAPALPVQDPQLLHHCQHCDMYFADNILYTIHM 383

  Fly   725 GYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS 758
            |.|..::.|:||:||.||........|.||..|:
Human   384 GCHGYENPFQCNICGCKCKNKYDFACHFARGQHN 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	271..291	CDD:275368	9/19 (47%)
		zf-H2C2_2	283..308	CDD:290200	12/24 (50%)
		C2H2 Zn finger	299..319	CDD:275368	8/19 (42%)
		C2H2 Zn finger	327..345	CDD:275368	0/17 (0%)
		C2H2 Zn finger	707..727	CDD:275371	12/19 (63%)
		C2H2 Zn finger	735..757	CDD:275371	9/21 (43%)
IKZF5	NP_001258769.1	C2H2 Zn finger	84..104	CDD:275368	4/19 (21%)
		zf-H2C2_2	96..121	CDD:404364	9/27 (33%)
		C2H2 Zn finger	112..132	CDD:275368	9/19 (47%)
		zf-H2C2_2	124..148	CDD:404364	11/23 (48%)
		C2H2 Zn finger	140..158	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..247		8/31 (26%)
		PHA03269	251..>361	CDD:165527	46/251 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..356		41/235 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	145	1.000	Inparanoid score	I4445
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264318at33208
OrthoFinder	1	1.000	-	-		FOG0003075
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.060