DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hb and IKZF4

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001338018.1	Gene:	IKZF4 / 64375	HGNCID:	13179	Length:	585	Species:	Homo sapiens

Alignment Length:	739	Identity:	159/739 - (21%)
Similarity:	240/739 - (32%)	Gaps:	271/739 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 TPPGLPNPMQHFYGGNLRPSP------------QPTPTSASTIAPVA-------------VATGS 170
            |||.||   :.|.||....:|            .|:........|.|             .::|.
Human     3 TPPALP---RRFQGGGRVRTPGSHRQGKDNLERDPSGGCVPDFLPQAQDSNHFIMESLFCESSGD 64

  Fly   171 S----EKLQALTPPMDVTP---PKSPAKS-SQSNIEPEKEHDQMSNS------------------ 209
            |    |.|.|...|...||   ..||::| |.::|:.|...|:.|:.
Human    65 SSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLEKDDSVIVE 129

  Fly   210 ---SEDMKYMAESEDDDTN---IRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKI 268
               ||.:.|...|..:..:   ||:|    :||:   ||..||:|.|.......|.|:| ..::.
Human   130 DSLSEPLGYCDGSGPEPHSPGGIRLP----NGKL---KCDVCGMVCIGPNVLMVHKRSH-TGERP 186

  Fly   269 LQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHS----SVYQ-YRCA 328
            ..|.:|......|.:|..||:.|..:|||:|..|:|.|..:..|..|.::||    :|.: |:|.
Human   187 FHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCN 251

  Fly   329 DCDYATKY----------CHSFKLHL----RKYGHKPG-MVLDEDGTPNPSLVIDVYGTRRGPKS 378
            .|..:.|.          ||::...|    :....:|| .:.|.:..|:..|
Human   252 YCGRSYKQQSTLEEHKERCHNYLQSLSTEAQALAGQPGDEIRDLEMVPDSML------------- 303

  Fly   379 KNGGPIASGGSGSGSRKSNVAAVA---PQQQQSQPAQPVATSQLSAALQGFP------------- 427
                      ..|..|.:.:..:|   .::::|.|.:.|...|:..:|...|
Human   304 ----------HSSSERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNSGGYEKDVE 358

  Fly   428 LVQGNSAPP---------AASPVLPLPASPAKSVASVEQTPSLPSPANLLPPLASLLQQNRNMAF 483
            ||..:|..|         .|..:.||...|...::  |.||.:.|....:.||...|:
Human   359 LVAHHSLEPGFGSSLAFVGAEHLRPLRLPPTNCIS--ELTPVISSVYTQMQPLPGRLE------- 414

  Fly   484 FPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSDNEEEEQDDEYERKSVDSAMDLSQGT 548
                                   .|..||                        :.:...||:.|.
Human   415 -----------------------LPGSRE------------------------AGEGPEDLADGG 432

  Fly   549 PVKEDEQQQQPQQPLAMNLKVEEEATPLM----SSSNASRRKGRVLKLDTLLQLRSEAMTSPEQL 609
            |:     ..:|:.||     .:..|:|..    |:...|..:.||..:.:|.|       .|
Human   433 PL-----LYRPRGPL-----TDPGASPSNGCQDSTDTESNHEDRVAGVVSLPQ-------GP--- 477

  Fly   610 KVPSTPMPTA-----SSPIAGRKPMPEEH-CSGTSSADESMETAHVPQANTSASSTASSSGNSSN 668
              |..|.||.     |...|...|.|:|. ..||..  .|.|...|
Human   478 --PPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPG--PSKEVLRV------------------- 519

  Fly   669 ASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAAGAIYECKYCDIFFKDAVLYTIHMGYHSCDDVF 733
                                   ...||.|..|   ::|::|.|.|.|.|::|||||.|...|.|
Human   520 -----------------------VGESGEPVKA---FKCEHCRILFLDHVMFTIHMGCHGFRDPF 558

  Fly   734 KCNMCGEKCDGPVGLFVHMARNAH 757
            :||:||...........|:.|..|
Human   559 ECNICGYHSQDRYEFSSHIVRGEH 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:290200	11/24 (46%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..345	CDD:275368	6/31 (19%)
		C2H2 Zn finger	707..727	CDD:275371	11/19 (58%)
		C2H2 Zn finger	735..757	CDD:275371	6/21 (29%)
IKZF4	NP_001338018.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..98		10/29 (34%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		zf-H2C2_2	174..198	CDD:404364	5/24 (21%)
		C2H2 Zn finger	189..209	CDD:275368	6/19 (32%)
		zf-H2C2_2	201..226	CDD:404364	11/24 (46%)
		SFP1	<211..271	CDD:227516	16/59 (27%)
		C2H2 Zn finger	217..237	CDD:275368	6/19 (32%)
		C2H2 Zn finger	250..271	CDD:275368	3/20 (15%)
		Interaction with FOXP3. /evidence=ECO:0000250\|UniProtKB:Q8C208	281..585		87/450 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..489		24/154 (16%)
		CTBP-binding motif PEDLA	425..429		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000