Protein Alignment hb and PRDM15

DIOPT Version :9

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_011527985.1
• Gene: PRDM15 / 63977
• HGNCID: 13999
• Length: 1441
• Species: Homo sapiens
• Alignment Length: 410
• Identity: 79/410 - (19%)
• Similarity: 132/410 - (32%)
• Gaps: 127/410 - (30%)

  Fly   234 HGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQ 298
            |..::.|.|..||....||.....|.:.| |..|..:|.:|......|.::..|.::|...|.|.
Human  1040 HDNVREYLCAECGKGMKTKHALRHHMKLH-KGIKEYECKECHRRFAQKVNMLKHCKRHTGIKDFM 1103

  Fly   299 CDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCD--YATKY-----------------CH------ 338
            |:.|..|...::.:.:|:..|:...|:.|:.||  |.|:|                 |.
Human  1104 CELCGKTFSERNTMETHKLIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKV 1168

  Fly   339 ----SFKLHLRK------------YGHKP-GMVLDED--GTPNPSLVIDVYGTRRG--------- 375
                |...|:|:            ..|.| ...:|..  |...|.|.::......|
Human  1169 STRASMSRHMRRKHPEVLAVRIDDLDHLPETTTIDASSIGIVQPELTLEQEDLAEGKHGKAAKRS 1233

  Fly   376 ------PKSKNGGPIASGG------------SGSGSRKSNVAAVAPQQ--------QQSQPAQPV 414
                  |:.:.|.|:....            :||...::|.|..:.||        ..:.|:..|
Human  1234 HKRKQKPEEEAGAPVPEDATFSEYSEKETEFTGSVGDETNSAVQSIQQVVVTLGDPNVTTPSSSV 1298

  Fly   415 ATSQL------SAALQGF----PLVQGNSAPPAA-----SPVLPL-------------------- 444
            ..:.:      :||...|    |:..|:...|..     :.:|.:
Human  1299 GLTNITVTPITTAAATQFTNLQPVAVGHLTTPERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQI 1363

  Fly   445 -PASPAKSVASVEQTPSLPSPANLLPPLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSP 508
             |...|.:..||....:|.:..|.:.||.|.|.....:.    |.       |..|..||....|
Human  1364 HPQPEASNPQSVAHFINLTTLVNSITPLGSQLSDQHPLT----WR-------AVPQTDVLPPSQP 1417

  Fly   509 RMREQLQQQNQQQSDNEEEE 528
            :...|...|.|.|::.::::
Human  1418 QAPPQQAAQPQVQAEQQQQQ 1437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	271..291	CDD:275368	4/19 (21%)
		zf-H2C2_2	283..308	CDD:290200	7/24 (29%)
		C2H2 Zn finger	299..319	CDD:275368	4/19 (21%)
		C2H2 Zn finger	327..345	CDD:275368	9/46 (20%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
PRDM15	XP_011527985.1	SET	349..465	CDD:214614
		GAGA_bind	<515..>580	CDD:283799
		COG5048	663..1125	CDD:227381	22/85 (26%)
		zf-C2H2	672..694	CDD:278523
		C2H2 Zn finger	674..694	CDD:275368
		C2H2 Zn finger	701..722	CDD:275368
		C2H2 Zn finger	735..751	CDD:275368
		C2H2 Zn finger	789..809	CDD:275368
		C2H2 Zn finger	838..858	CDD:275368
		C2H2 Zn finger	865..885	CDD:275368
		C2H2 Zn finger	928..949	CDD:275370
		C2H2 Zn finger	956..976	CDD:275368
		C2H2 Zn finger	992..1012	CDD:275368
		zf-H2C2_2	1004..1029	CDD:290200
		C2H2 Zn finger	1020..1040	CDD:275368	79/410 (19%)
		C2H2 Zn finger	1048..1068	CDD:275368	6/19 (32%)
		zf-H2C2_2	1060..1085	CDD:290200	6/25 (24%)
		C2H2 Zn finger	1076..1096	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1104..1124	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1132..1153	CDD:275368	6/20 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910