DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hb and rest

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001340795.1	Gene:	rest / 564772	ZFINID:	ZDB-GENE-080415-1	Length:	854	Species:	Danio rerio

Alignment Length:	858	Identity:	172/858 - (20%)
Similarity:	278/858 - (32%)	Gaps:	265/858 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QQQPMDTLCAMTPSPSQNDQNSLQHYDANLQQQLLQQQQYQQHFQ-------------------- 111
            |...:.|:...:.|.|:.|.:::..|..:..:.|..||  ..|.|
Zfish    50 QMMELQTVACSSYSDSEEDDDAVVRYSMDTSEDLYTQQ--ASHIQPEPVLEEIEIVRVGRPPNQT 112

  Fly   112 ------AAQQQHHHHHHLMGGFNPLTPPGLPNPMQHFYGGNLRPSPQPTPTSASTIAPVAVATGS 170
                  |:.:|......::........|....|.| :.|.|.:.......|..:....|.....|
Zfish   113 ESTENAASAEQKRTTLAILESSKKKKKPFFCKPCQ-YQGENEQEFIVHIRTHGAKKMLVVNGGDS 176

  Fly   171 SEKLQALTPPMDVTPPKSPAKSSQSNIEPEKEHDQMS-NSSEDMKYMAE-----SEDDDTNIRMP 229
            .|.|.|...|....|   .|:|::||.:.....::.. |::....|||.     .|.:|..:
Zfish   177 DEDLSADAGPQTSVP---NAESAESNSKGVIRCERCGYNTNRFDHYMAHLKHHTKEGEDQRV--- 235

  Fly   230 IYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQ 294
                      :||..|....|::..:..|.|.|. |.|:..|.:|.:.::.|::...|||.|..:
Zfish   236 ----------FKCTICAYTTISQYHWKKHLRNHF-PSKLFTCSQCSYFSDRKNNYIQHIRTHTGE 289

  Fly   295 KPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDY----------------------ATKYC 337
            :||||..|.|:...|:.|..|.::||....::|.:|.|                      :..||
Zfish   290 RPFQCIYCEYSSSQKTHLTRHMRTHSGERPFKCDNCSYLAANQHEVTRHARQVHNGPKPLSCPYC 354

  Fly   338 H-------SFKLHLR-------------KY-------------GHKPG---MVLD---------- 356
            .       :||.|:.             ||             ...||   :.:|
Zfish   355 QYKTADRSNFKKHVELHVNPRQFLCPVCKYAASKKCNLQYHIKSRHPGCKDISMDVSKVRLRVKR 419

  Fly   357 ---EDGTPNPSLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKSNVAAVAPQQQQS---------Q 409
               :|.:||.   :.....:...:.::.|||    :.|..:.|.:.||...::.|         |
Zfish   420 SDGDDASPNK---LTAEQAKIMEELEDAGPI----NLSIKKPSKLNAVVETEKSSKKNMDGKANQ 477

  Fly   410 PAQPVATSQLSAALQGFPLVQGNSAPPAASPVLPLPASPAKSVASVEQTPSLPSPANLLPPLASL 474
            | ||.....||            ...|.......|....|  |...|:|.:..:..|
Zfish   478 P-QPNEKKSLS------------KNEPKEKTAKKLKGKTA--VKDTEETQTEDTRVN-------- 519

  Fly   475 LQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQN--QQQSD-----------NEE 526
                           |.:.....:::|..|..|.:.:|:..:.:  |||||           ||.
Zfish   520 ---------------NKKETKKAEKSAEKALKSRQKKEKPVKDSSVQQQSDDCEQTQHTPQQNET 569

  Fly   527 EEQDDEYERKS---VDSAMDLSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMSSSNASRRKG- 587
            :|...|.|.:|   :|:|.|..:....|..::|.:..:.......||||.   :....|.:||.
Zfish   570 QENRPEKENRSLTEIDNAKDCGKVQTKKPCKKQTKTLKVCGETQNVEEEE---IMRQKAGKRKAD 631

  Fly   588 ----------RVLKLDTLLQLRSEA-MTSPEQLKVPSTPMPTASS-----------PIAGRKP-- 628
                      |..|.|:.....||| .|:||.::..|:....||.           |:|..:|
Zfish   632 NPAEPKQRIKRTKKKDSGKPTTSEANQTNPEVMESESSEANNASKPDDSIDESQNPPVAESRPDV 696

  Fly   629 -------MPEEHCSGTSSADESME----TA-----HVPQANTSASSTASSSG------------- 664
                   .|.|...........:|    ||     .|...|...|.|.|...
Zfish   697 EPQSVPDCPIEKAPAVEEVQRPLEVEISTAAPDAPEVDSGNEMPSPTDSDGAPGFTPTLPLQHKP 761

  Fly   665 ----NSSNASSNSNGNSSSNSSSNGT-TSAVAA--------PPSGTPAAAGAI--YECKYCDIFF 714
                :.....||..|:..|:|:|.|: .|.:.|        |.....|:|..:  :.|.:||..|
Zfish   762 ADAEDDEGIHSNDGGSDISDSASEGSYDSGLMAGAEKLPETPTEERDASAARLLSHTCIFCDRSF 826

  Fly   715 KDAVLYTIHMGYH 727
            ...:.|..|:..|
Zfish   827 ALEMDYRKHLNRH 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:290200	10/24 (42%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..345	CDD:275368	8/46 (17%)
		C2H2 Zn finger	707..727	CDD:275371	6/19 (32%)
		C2H2 Zn finger	735..757	CDD:275371
rest	NP_001340795.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..199		8/29 (28%)
		C2H2 Zn finger	238..258	CDD:275368	5/19 (26%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	278..303	CDD:316026	10/24 (42%)
		zf-C2H2_2	293..>367	CDD:315435	16/73 (22%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		zf-H2C2_2	306..327	CDD:316026	6/20 (30%)
		C2H2 Zn finger	326..343	CDD:275370	1/16 (6%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		C2H2 Zn finger	379..397	CDD:275368	2/17 (12%)
		MIP-T3	453..>769	CDD:313469	70/356 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592554
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264318at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940