DRSC/TRiP Functional Genomics Resources

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Protein Alignment hb and ZNF446

DIOPT Version :10

Sequence 1:NP_731267.1 Gene:hb / 41032 FlyBaseID:FBgn0001180 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_060378.1 Gene:ZNF446 / 55663 HGNCID:21036 Length:450 Species:Homo sapiens


Alignment Length:364 Identity:90/364 - (24%)
Similarity:128/364 - (35%) Gaps:115/364 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 AANIKQEPGHHLDGNSVA-SSP---RQSPIPSTNHLEQFLKQQQQQLQQQPMDTLCAMTPSPSQN 84
            :.::|:||  ::||..|| |||   .|||..:..|             |:|..|  :..|...|.
Human   163 SCSVKEEP--NVDGQEVAPSSPPLAAQSPEGNHGH-------------QEPAST--SFHPPRIQE 210

  Fly    85 DQNSLQ------HYDANLQQQ-LLQQQQYQQHFQAAQQQHHHHHHLMG---------GFNPLTPP 133
            :...|.      ::||.|::. .:.......|...||.|......|.|         |.....||
Human   211 EWGLLDRSQKELYWDAMLEKYGTVVSLGLPPHQPEAQAQSELGMLLTGTGVCRSLRSGNESEGPP 275

  Fly   134 GLPNPMQHFYGGNLRPSPQPTP------TSASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKS 192
            |.|         ..:|...|.|      :.|:|.|| .|..|        |||:...|  :||  
Human   276 GCP---------EAQPPQGPGPAAWEGLSGAATPAP-TVRPG--------TPPVPTQP--TPA-- 318

  Fly   193 SQSNIEPEKEHDQMSNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNYKCKTCGVVAITKVDFWA 257
             ::.:||                                 :....|.|.|:.||.....|..|..
Human   319 -ETRLEP---------------------------------AATPRKPYTCEQCGRGFDWKSVFVI 349

  Fly   258 HTRTHMKPDKILQCP---------KCP-FVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSML 312
            |.|||.....: |.|         |.| ....|.||..   |.....:.:.|::|..:...||.|
Human   350 HHRTHTSGPGV-QSPGLATGESTEKPPQGEVAFPHHPR---RSLTGPRSYPCEECGCSFSWKSQL 410

  Fly   313 NSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKP 351
            ..|||||:...::.|:||..|..:.....:| || ||:|
Human   411 VIHRKSHTGQRRHFCSDCGRAFDWKSQLVIH-RK-GHRP 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbNP_731267.1 C2H2 Zn finger 242..262 CDD:275368 7/19 (37%)
C2H2 Zn finger 271..291 CDD:275368 7/29 (24%)
zf-H2C2_2 283..308 CDD:463886 4/24 (17%)
C2H2 Zn finger 299..319 CDD:275368 8/19 (42%)
C2H2 Zn finger 327..345 CDD:275368 5/17 (29%)
C2H2 Zn finger 707..727 CDD:275371
C2H2 Zn finger 735..757 CDD:275371
ZNF446NP_060378.1 SCAN 22..137 CDD:128708
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 130..155
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 168..205 16/53 (30%)
KRAB <209..238 CDD:460171 5/28 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 263..331 22/123 (18%)
C2H2 Zn finger 334..354 CDD:275368 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..389 9/38 (24%)
C2H2 Zn finger 397..417 CDD:275368 8/19 (42%)
C2H2 Zn finger 425..445 CDD:275368 7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

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