DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and ikzf5

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_012822117.1	Gene:	ikzf5 / 550109	XenbaseID:	XB-GENE-978531	Length:	453	Species:	Xenopus tropicalis

Alignment Length:	600	Identity:	129/600 - (21%)
Similarity:	197/600 - (32%)	Gaps:	232/600 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 SSQSNIEPE------KEHDQMSNSSEDMKYMAESEDDDTN------IRMPIYNSHGKMKN----- 239
            |..|:.|.|      :.||.:|.:|..:...|...|.|.|      :.:.:..|.|.:.:
Frog    32 SVSSDKEAETLQGGTQNHDALSANSPCLALPAAGTDSDQNGLDHPSVEVSLDESAGMLVDGFERT 96

  Fly   240 ----YKCKTCGVVAITKVDFWAHTRTHM--KPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQ 298
                .||:.|...:........|.|.|.  ||.:   |..|||.:.::.|||.|:|.|..:||::
Frog    97 FDGKLKCRYCNYASKGTARLIEHIRIHTGEKPHR---CHLCPFASAYERHLEAHMRSHTGEKPYK 158

  Fly   299 CDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVLDEDGTPNP 363
            |:.||:.|.::|.|:.||:                           ||  ||   :|...|| .|
Frog   159 CELCSFRCSDRSNLSHHRR---------------------------RK--HK---MLPIKGT-RP 190

  Fly   364 SLVIDVYGTRRGPKSKNGGPIASGGSGSG-SRKSNVAAVAPQQQQSQPAQPVATSQLSAALQGFP 427
            ||         |.| |..|.:....|..| :|::.:
Frog   191 SL---------GNK-KMWGVLQKKVSSLGYTRRTLI----------------------------- 216

  Fly   428 LVQGNSAPPAASPVLPLPASPAKSVASVEQTPSLPSPANLLPPLASLLQQNRNMAFFPYWNLNLQ 492
                |.:||:.     :...|........:.||:.|.|                         .:
Frog   217 ----NLSPPSM-----VVHKPDYLSDFAHEIPSIQSEA-------------------------YE 247

  Fly   493 MLAAQQQAAVLAQLSPRMREQLQQQNQQQSDNEEEEQDDEYERKSVDSAMDLSQGTPVKEDEQQQ 557
            .||....:.||:                                                    :
Frog   248 SLAKASHSGVLS----------------------------------------------------R 260

  Fly   558 QPQQPLAMNLKVEEEATPLMSSSNASRRKGRVLKLDTLLQLRSEAMTSPEQLKVPSTPMPTASSP 622
            .||:.:..|                        .|:.|..|..:..:.|...:.|::|   .:.|
Frog   261 DPQELMVDN------------------------PLNQLSTLAGQLSSLPPDTQNPASP---DTGP 298

  Fly   623 IAGRKPM-----PEEHCSGTSSADESMETAHVPQANTSASSTASSSGNSSNASSNSNGNSSSNSS 682
            ....||.     |...|:...|..       |.|:::.||.....:.|..|.|..: |.||..|.
Frog   299 CPDEKPFMIQQPPPPACASAVSTS-------VAQSSSPASPEGRPTHNHRNCSPMA-GPSSERSG 355

  Fly   683 SNGTTSAVAAPPSGTPAAA------GAIYECKYCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEK 741
            ...|.|...:.|| |||.|      ..::.|::||::|.|.:|||||||.|..::.|:||:||.|
Frog   356 RTSTPSISNSQPS-TPAPALPAQDPQLLHHCQHCDMYFADNILYTIHMGCHGFENPFQCNICGCK 419

  Fly   742 CDGPVGLFVHMARNA 756
            |........|.||.|
Frog   420 CKNKYDFACHFARGA 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	271..291	CDD:275368	9/19 (47%)
		zf-H2C2_2	283..308	CDD:290200	12/24 (50%)
		C2H2 Zn finger	299..319	CDD:275368	8/19 (42%)
		C2H2 Zn finger	327..345	CDD:275368	0/17 (0%)
		C2H2 Zn finger	707..727	CDD:275371	12/19 (63%)
		C2H2 Zn finger	735..757	CDD:275371	9/21 (43%)
ikzf5	XP_012822117.1	C2H2 Zn finger	103..123	CDD:275368	4/19 (21%)
		zf-H2C2_2	115..140	CDD:404364	9/27 (33%)
		C2H2 Zn finger	131..151	CDD:275368	9/19 (47%)
		zf-H2C2_2	143..167	CDD:404364	11/23 (48%)
		C2H2 Zn finger	159..177	CDD:275368	7/17 (41%)
		PHA02682	<286..>384	CDD:177464	27/109 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	143	1.000	Inparanoid score	I4366
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264318at33208
OrthoFinder	1	1.000	-	-		FOG0003075
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.060