DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	166	Identity:	46/166 - (27%)
Similarity:	72/166 - (43%)	Gaps:	7/166 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 KSPAKSSQSNIEPEKEHDQMSNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNYKCKTCGVVAIT 251
            |:.::|..|..:|..:.:::|...|..|..:.|.....:.|:     |...|.:||..||.....
Human   501 KNCSQSVHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRI-----HTGEKPHKCSECGKGFSE 560

  Fly   252 KVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHR 316
            :.:..||.||| ..::..||.:|.........|..|.|.|..:||:||..|.....|.|..::||
Human   561 RSNLTAHLRTH-TGERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFNNSSQFSAHR 624

  Fly   317 KSHSSVYQYRCADCDYATKYCHSFKLHLRKY-GHKP 351
            :.|:....|:||.|.........|..|.:.: |.||
Human   625 RIHTGESPYKCAVCGKIFNNSSHFSAHRKTHTGEKP 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		zf-H2C2_2	283..308	CDD:290200	9/24 (38%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..345	CDD:275368	5/17 (29%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482
		COG5048	<455..668	CDD:227381	46/166 (28%)
		zf-C2H2	522..543	CDD:278523	4/25 (16%)
		C2H2 Zn finger	523..543	CDD:275368	4/24 (17%)
		zf-H2C2_2	535..559	CDD:290200	7/28 (25%)
		C2H2 Zn finger	551..571	CDD:275368	6/19 (32%)
		zf-H2C2_2	563..588	CDD:290200	8/25 (32%)
		C2H2 Zn finger	579..599	CDD:275368	5/19 (26%)
		zf-H2C2_2	591..616	CDD:290200	9/24 (38%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	623..644	CDD:290200	7/20 (35%)
		C2H2 Zn finger	635..655	CDD:275368	5/19 (26%)
		zf-H2C2_2	647..671	CDD:290200	5/14 (36%)
		zf-C2H2	661..683	CDD:278523	46/166 (28%)
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930