DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hb and Zkscan6

DIOPT Version :10

Sequence 1:NP_731267.1 Gene:hb / 41032 FlyBaseID:FBgn0001180 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_080383.2 Gene:Zkscan6 / 52712 MGIID:1289293 Length:556 Species:Mus musculus


Alignment Length:422 Identity:84/422 - (19%)
Similarity:138/422 - (32%) Gaps:111/422 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MQNWETTATTNYEQHNAWYNSMFAANIKQEPGHHLDGNSVASSPRQSPI---------------P 50
            :|| .::||.....|.....|      ..||...|..:.:.:.|.:.|:               .
Mouse   173 LQN-SSSATGELLSHGVKEES------DMEPELALAASQLPARPEERPVRDQELGTAVLPPLQEE 230

  Fly    51 STNHLEQFLKQQQQQLQQQPMDTLCAMTP-----SPSQNDQNSLQHYDANLQQQLL--------- 101
            ...||:...|:|...|.   ::|...|..     |.|:.|..:|..|...|....|         
Mouse   231 QWRHLDSTQKEQYWDLM---LETYGKMVSGVAGISNSKPDLTNLAEYGEELVGLHLHGAEKMARL 292

  Fly   102 --QQQQYQQHFQAAQQQHHHHHHLMGGF---NPLTPP--------GLPNPMQHFYGGNLRPSPQP 153
              ::.:.:...:....::|.....:..|   :...||        |...|  |.:||:       
Mouse   293 PCKEDRQENDKENLNLENHRDQGCLDVFCQASGEAPPQTALSDFFGESEP--HRFGGD------- 348

  Fly   154 TPTSASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKSSQSN---------IEPEKEHDQMSNS 209
                   ..|.|:.....|...|...|.:....|.|.:..||:         :|.::|..|...:
Mouse   349 -------SVPEALENHQGEGTGAHLFPYERGSGKQPGQHIQSSSLGELTALWLEEKREASQKGQA 406

  Fly   210 SEDMKYMAESEDDDTNIRMPIYNSHGK--MKN---------------YKCKTCGVVAITKVDFWA 257
            ...|..           ::|.....||  .:|               :.|..|....:...||..
Mouse   407 RSPMAQ-----------KLPTCRECGKTFYRNSQLVFHQRTHTGETYFHCHICKKAFLRSSDFVK 460

  Fly   258 HTRTHM--KPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHS 320
            |.|||.  ||.|...|.|  ..::|. .|.:|.:.|..:||::|..|..:.:.:|..|.|::.|:
Mouse   461 HQRTHTGEKPCKCDYCGK--GFSDFS-GLRHHEKIHTGEKPYKCPLCEKSFIQRSNFNRHQRVHT 522

  Fly   321 SVYQYRCADCDYATKYCHSFKLHLRKY-GHKP 351
            ....|:|..|.....:..|...|.|.: |..|
Mouse   523 GEKPYKCTHCGKQFSWSSSLDKHQRSHLGKMP 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbNP_731267.1 C2H2 Zn finger 242..262 CDD:275368 6/19 (32%)
C2H2 Zn finger 271..291 CDD:275368 5/19 (26%)
zf-H2C2_2 283..308 CDD:463886 7/24 (29%)
C2H2 Zn finger 299..319 CDD:275368 5/19 (26%)
C2H2 Zn finger 327..345 CDD:275368 4/17 (24%)
C2H2 Zn finger 707..727 CDD:275371
C2H2 Zn finger 735..757 CDD:275371
Zkscan6NP_080383.2 SCAN 37..144 CDD:128708
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..195 6/28 (21%)
KRAB 229..278 CDD:214630 12/51 (24%)
C2H2 Zn finger 417..437 CDD:275368 3/19 (16%)
COG5048 <428..541 CDD:227381 28/115 (24%)
C2H2 Zn finger 445..465 CDD:275368 6/19 (32%)
C2H2 Zn finger 473..493 CDD:275368 5/22 (23%)
C2H2 Zn finger 501..521 CDD:275368 5/19 (26%)
C2H2 Zn finger 529..549 CDD:275368 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.