DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and Zkscan6

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001289303.1	Gene:	Zkscan6 / 52712	MGIID:	1289293	Length:	556	Species:	Mus musculus

Alignment Length:	422	Identity:	84/422 - (19%)
Similarity:	138/422 - (32%)	Gaps:	111/422 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQNWETTATTNYEQHNAWYNSMFAANIKQEPGHHLDGNSVASSPRQSPI---------------P 50
            :|| .::||.....|.....|      ..||...|..:.:.:.|.:.|:               .
Mouse   173 LQN-SSSATGELLSHGVKEES------DMEPELALAASQLPARPEERPVRDQELGTAVLPPLQEE 230

  Fly    51 STNHLEQFLKQQQQQLQQQPMDTLCAMTP-----SPSQNDQNSLQHYDANLQQQLL--------- 101
            ...||:...|:|...|.   ::|...|..     |.|:.|..:|..|...|....|
Mouse   231 QWRHLDSTQKEQYWDLM---LETYGKMVSGVAGISNSKPDLTNLAEYGEELVGLHLHGAEKMARL 292

  Fly   102 --QQQQYQQHFQAAQQQHHHHHHLMGGF---NPLTPP--------GLPNPMQHFYGGNLRPSPQP 153
              ::.:.:...:....::|.....:..|   :...||        |...|  |.:||:
Mouse   293 PCKEDRQENDKENLNLENHRDQGCLDVFCQASGEAPPQTALSDFFGESEP--HRFGGD------- 348

  Fly   154 TPTSASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKSSQSN---------IEPEKEHDQMSNS 209
                   ..|.|:.....|...|...|.:....|.|.:..||:         :|.::|..|...:
Mouse   349 -------SVPEALENHQGEGTGAHLFPYERGSGKQPGQHIQSSSLGELTALWLEEKREASQKGQA 406

  Fly   210 SEDMKYMAESEDDDTNIRMPIYNSHGK--MKN---------------YKCKTCGVVAITKVDFWA 257
            ...|..           ::|.....||  .:|               :.|..|....:...||..
Mouse   407 RSPMAQ-----------KLPTCRECGKTFYRNSQLVFHQRTHTGETYFHCHICKKAFLRSSDFVK 460

  Fly   258 HTRTHM--KPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHS 320
            |.|||.  ||.|...|.|  ..::|. .|.:|.:.|..:||::|..|..:.:.:|..|.|::.|:
Mouse   461 HQRTHTGEKPCKCDYCGK--GFSDFS-GLRHHEKIHTGEKPYKCPLCEKSFIQRSNFNRHQRVHT 522

  Fly   321 SVYQYRCADCDYATKYCHSFKLHLRKY-GHKP 351
            ....|:|..|.....:..|...|.|.: |..|
Mouse   523 GEKPYKCTHCGKQFSWSSSLDKHQRSHLGKMP 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		zf-H2C2_2	283..308	CDD:290200	7/24 (29%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..345	CDD:275368	4/17 (24%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
Zkscan6	NP_001289303.1	SCAN	37..144	CDD:383046
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..195		6/28 (21%)
		KRAB_A-box	229..278	CDD:383038	12/51 (24%)
		C2H2 Zn finger	417..437	CDD:275368	3/19 (16%)
		COG5048	<428..541	CDD:227381	28/115 (24%)
		C2H2 Zn finger	445..465	CDD:275368	6/19 (32%)
		C2H2 Zn finger	473..493	CDD:275368	5/22 (23%)
		C2H2 Zn finger	501..521	CDD:275368	5/19 (26%)
		C2H2 Zn finger	529..549	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930