DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hb and ikzf5

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_991164.1	Gene:	ikzf5 / 402893	ZFINID:	ZDB-GENE-040801-209	Length:	419	Species:	Danio rerio

Alignment Length:	633	Identity:	130/633 - (20%)
Similarity:	203/633 - (32%)	Gaps:	277/633 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 PMDVTPPKSPAKSSQSNIEPEKEHDQMSN-------SSEDMK-YMAESEDDDTNIRMPIYNSHGK 236
            |:|.      .|..|..:..:.:|..|.:       .|:|:: .:|::..:...:.|.:.:|.|.
Zfish     8 PLDF------VKDFQEYLSQQTQHVNMISGSVIGVKDSDDLQGELAQNGLEHPAVDMSLEDSSGM 66

  Fly   237 M-----KNY----KCKTCGVVAITKVDFWAHTRTHM--KPDKILQCPKCPFVTEFKHHLEYHIRK 290
            :     :.|    ||:.|............|.|.|.  ||.:   |..|||.:.::.|||.|:|.
Zfish    67 LVDGFERTYDGKLKCRYCNYATRGTARLIEHIRIHTGEKPHR---CHLCPFASAYERHLEAHMRS 128

  Fly   291 HKNQKPFQCDKCSYTCVNKSMLNSHRK---------------SHS---SVYQYRCADCDYATKYC 337
            |..:||::|:.||:.|.::|.|:.||:               ||.   ||.|.|.....|..:..
Zfish   129 HTGEKPYKCELCSFRCSDRSNLSHHRRRRHKLLPMKGARSALSHRKMLSVLQKRGNSLSYGRRLL 193

  Fly   338 HSFKLHLRKYGHKPGMVLDE-------------DGTPNPSLVIDVYGTRRGPKSKNG---GPIAS 386
            .:..        .|.|||.:             |..|:..|..:.|         ||   .|.|.
Zfish   194 INLS--------PPSMVLQKPSSEQQHLGDFTHDLPPHAHLHQEAY---------NGLGKDPQAI 241

  Fly   387 GGS-GSGSRKSNVAAVAPQQQQSQPAQPVATSQLSAALQGFPLVQGNSAPPAASPVLPLPASPAK 450
            ||: |||||:
Zfish   242 GGAIGSGSRE------------------------------------------------------- 251

  Fly   451 SVASVEQTPSLPSPANLLPPLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQ 515
                 :|..:|.:|.|.|..||.                        |.|::.::
Zfish   252 -----DQDMALDNPLNQLSTLAG------------------------QLASIPSE---------- 277

  Fly   516 QQNQQQSDNEEEEQDDEYERKSVDSAMDLSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMSSS 580
                                         ::|.||          .|.|.:|. :|:.|.|:
Zfish   278 -----------------------------AEGAPV----------SPGAESLP-DEKTTFLV--- 299

  Fly   581 NASRRKGRVLKLDTLLQLRSEAMTSPEQLKVPSTPMPTASSPIAGRKPMPEEHCSGTSSADESME 645
                               .:.:|:|..:.|.:.   .|||||
Zfish   300 -------------------QQPVTAPAAVSVNTA---QASSPI---------------------- 320

  Fly   646 TAHVPQANTSASSTASSS-GNSSNASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAAGAIYECKY 709
               .|:..|:|.|..|.. |..|..:|..:|    .:|..||.:.|..|.        .::.|.:
Zfish   321 ---TPEPRTAAHSGCSPGVGPCSERTSTPSG----TNSQPGTPTPVQDPQ--------MLHHCPH 370

  Fly   710 CDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAH 757
            |.|:|.|.:|||||||.|..::.|:||:||.:|........|.||..|
Zfish   371 CHIYFPDNILYTIHMGCHGYENPFQCNICGHRCRNSYDFACHFARGQH 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	271..291	CDD:275368	9/19 (47%)
		zf-H2C2_2	283..308	CDD:290200	12/24 (50%)
		C2H2 Zn finger	299..319	CDD:275368	8/34 (24%)
		C2H2 Zn finger	327..345	CDD:275368	1/17 (6%)
		C2H2 Zn finger	707..727	CDD:275371	12/19 (63%)
		C2H2 Zn finger	735..757	CDD:275371	8/21 (38%)
ikzf5	NP_991164.1	C2H2 Zn finger	81..101	CDD:275368	4/19 (21%)
		zf-H2C2_2	94..118	CDD:290200	9/26 (35%)
		COG5048	105..>163	CDD:227381	22/60 (37%)
		C2H2 Zn finger	109..129	CDD:275368	9/19 (47%)
		zf-H2C2_2	121..145	CDD:290200	11/23 (48%)
		C2H2 Zn finger	137..155	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..255		17/120 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..360		18/81 (22%)
		C2H2 Zn finger	368..388	CDD:275370	12/19 (63%)
		C2H2 Zn finger	396..412	CDD:275370	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264318at33208
OrthoFinder	1	1.000	-	-		FOG0003075
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010