DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hb and ZSCAN5B

DIOPT Version :9

Sequence 1:NP_731267.1 Gene:hb / 41032 FlyBaseID:FBgn0001180 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_001073925.2 Gene:ZSCAN5B / 342933 HGNCID:34246 Length:495 Species:Homo sapiens


Alignment Length:338 Identity:72/338 - (21%)
Similarity:122/338 - (36%) Gaps:92/338 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 NIKQEPGHHLDGNSVASSPRQSPIPSTNHLEQFLKQQQQQLQQQPMDTLCAMTPSPSQNDQNSLQ 90
            |.::.||        .||| :..:|.:.:|.: .|:.::..::..::.:.|.|||....::.:|.
Human   228 NREENPG--------LSSP-EPQLPKSPNLVR-AKEGKEPQKRASVENVDADTPSACVVEREALT 282

  Fly    91 HY----DA-NLQQ--------QLLQQQQYQQHFQAAQQQHHHHHHLMGGFNPLTPPGLPNPMQHF 142
            |.    || ||..        ..:.|::.|..   |....:.........||:..||...|:.| 
Human   283 HSGNRGDALNLSSPKRSKPDASSISQEEPQGE---ATPVGNRESPGQAEINPVHSPGPAGPVSH- 343

  Fly   143 YGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKSSQSNIEPEKEHDQMS 207
                      |....|..:.|.|               .||                        
Human   344 ----------PDGQEAKALPPFA---------------CDV------------------------ 359

  Fly   208 NSSEDMKYMAESEDDDTNIRMPIY-NSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQC 271
             .::..||.::         :.|: .||...:.::|..|....:...|...|.|.| ..::...|
Human   360 -CNKSFKYFSQ---------LSIHRRSHTGDRPFQCDLCRKRFLQPSDLRVHQRVH-TGERPYMC 413

  Fly   272 PKCPFVTEFKHH--LEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYAT 334
            ..|.  ..|.|.  |:.|.|.|..::||:|..||....:|..||.|:::||....|:|..|..|.
Human   414 DVCQ--KRFAHESTLQGHKRIHTGERPFKCKYCSKVFSHKGNLNVHQRTHSGEKPYKCPTCQKAF 476

  Fly   335 KYCHSFKLHLRKY 347
            :...:||.||:.:
Human   477 RQLGTFKRHLKTH 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hbNP_731267.1 C2H2 Zn finger 242..262 CDD:275368 5/19 (26%)
C2H2 Zn finger 271..291 CDD:275368 7/21 (33%)
zf-H2C2_2 283..308 CDD:290200 9/26 (35%)
C2H2 Zn finger 299..319 CDD:275368 7/19 (37%)
C2H2 Zn finger 327..345 CDD:275368 6/17 (35%)
C2H2 Zn finger 707..727 CDD:275371
C2H2 Zn finger 735..757 CDD:275371
ZSCAN5BNP_001073925.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
SCAN 40..124 CDD:153421
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..183
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 227..347 29/142 (20%)
zf-C2H2 355..377 CDD:395048 6/70 (9%)
C2H2 Zn finger 357..377 CDD:275368 5/53 (9%)
zf-H2C2_2 370..394 CDD:404364 5/23 (22%)
C2H2 Zn finger 385..405 CDD:275368 5/19 (26%)
C2H2 Zn finger 413..433 CDD:275368 7/21 (33%)
zf-H2C2_2 426..450 CDD:404364 9/23 (39%)
C2H2 Zn finger 441..461 CDD:275368 7/19 (37%)
zf-H2C2_2 453..478 CDD:404364 9/24 (38%)
C2H2 Zn finger 469..489 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156883
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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