Protein Alignment hb and Zfp518a

DIOPT Version :10

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001025209.1
• Gene: Zfp518a / 309478
• RGDID: 1305314
• Length: 1478
• Species: Rattus norvegicus
• Alignment Length: 736
• Identity: 145/736 - (19%)
• Similarity: 221/736 - (30%)
• Gaps: 214/736 - (29%)

  Fly   135 LPNP--MQH---FYGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKSSQ 194
            :||.  |:|   .|....:..||....|.| :..|:.|.|.:::.:  :...:....|..||.
  Rat    59 IPNEILMKHEVEKYRKLFQSKPQTARKSVS-VRTVSCAKGCAQRCE--SERAEDEAGKMCAKI-- 118

  Fly   195 SNIEPEKEHDQMSNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHT 259
            .|....|..|:...|..|::...|..            .||::.::.|:.|...|.....|..|.
  Rat   119 LNFTCSKCQDRTQYSPNDLQKHFEMW------------HHGELPSFPCEMCSFSASDFQIFKQHR 171

  Fly   260 RTH----MKPDKI------------------------LQCPKCPFVTEFKHHLEYHIRKHKNQKP 296
            :||    :|.|..                        .||.:|.|.|:.......||.:|| :..
  Rat   172 KTHRNTFVKCDICNSERSYTLLDLTKHFTSKHCVNGNFQCEECRFFTQDVGTFVQHIHRHK-EVH 235

  Fly   297 FQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDY----------------------------- 332
            ::|.||.:.|..|..|..|.:.||....:.|..|.|
  Rat   236 YKCGKCHHLCFTKGELQKHLRVHSGTLPFTCHYCSYGAIHKDQLVRHVITLHKEHLYAKEKLERD 300

  Fly   333 -----ATKYCHSFKLHLRKYGHKPGMVL----------DEDGTPNPSL--VIDVYGTRRGPKS-- 378
                 ..|.....||.|::|...|....          ||....|...  ::....|:...:|
  Rat   301 QYDKRVAKTTTGLKLILKRYKIGPTKTFWKRKTIASGNDESIGKNAQAFNIVSKTQTKSEDQSQE 365

  Fly   379 ----KNGG---------PIASGG------SGSGSRKSNVAAVAPQQQQSQPAQPVA--------- 415
                :.||         ||.||.      |.....|::..|.||....|....|..
  Rat   366 QLNEEKGGRQHCEDGDKPIESGSEKATVLSTGQCNKADEGASAPSSVLSAVQGPTVLLVRNNKIT 430

  Fly   416 -TSQLSAALQGFPLVQGN-----SAPPAASPVLPLPASPAKSVASVEQTPSLPSPAN-------- 466
             .:..||...||.:|.|.     ...||...:||.||....:  ..|.|.:||..|.
  Rat   431 IPANYSAKFMGFKMVDGRQHIVIKLLPANKQILPSPALQPNT--EKESTANLPPQAMDNTGFATG 493

  Fly   467 -----------------LLPPLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQL 514
                             ..|.|...:...:..||....|..|||:...:....|...|..:....
  Rat   494 LTAMNDTDFVKAAPLSCSSPELPRKVISEKETAFISEKNNMLQMVDDSKSVTSLPTPSESVTSVR 558

  Fly   515 QQQNQQQSDNEEEEQDDEYERKSVDSAMDLSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMSS 579
            .....:..||.     |.:|..|..|..||. ||.:         ..|..:||.:...|......
  Rat   559 LTTKVEARDNV-----DLWENPSTQSHPDLI-GTSI---------NSPDKVNLTIRPNAYSCGDM 608

  Fly   580 SNASRRKGRVLKLDTLLQLRSEAMTSPEQLKVPSTPMPTASS---PIAGRKPMPEEHCSGTSSAD 641
            .|..                         :...::.:|..||   ..:.:..:|..:.|..::..
  Rat   609 HNYC-------------------------INYVNSELPAESSNCFEFSNQGSLPFHNYSKVNNKR 648

  Fly   642 ESMETAHVPQ--ANTSASSTASSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAAGAI 704
            .......|.:  ...|::.|.:....|.:.:::.....||||.|   ..|..:|.|||......|
  Rat   649 RRFSRGAVCENLQRESSNKTVTQQSTSDSDTTSPLRKESSNSDS---LLASISPLSGTLKIKTEI 710

  Fly   705 YECKYCDI----FFKDAVLYT 721
            .|  .||:    .|.:..|:|
  Rat   711 EE--PCDLEETQNFNEQSLFT 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:463886	8/24 (33%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..345	CDD:275368	6/51 (12%)
		C2H2 Zn finger	707..727	CDD:275371	5/19 (26%)
		C2H2 Zn finger	735..757	CDD:275371
Zfp518a	NP_001025209.1	C2H2 Zn finger	181..203	CDD:275368	1/21 (5%)
		C2H2 Zn finger	211..231	CDD:275368	6/19 (32%)
		C2H2 Zn finger	238..258	CDD:275368	7/19 (37%)
		zf-H2C2_2	250..271	CDD:463886	6/20 (30%)
		C2H2 Zn finger	266..283	CDD:275368	3/16 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..394		8/38 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	464..484		7/21 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..694		9/40 (23%)