Protein Alignment hb and ZNF337

DIOPT Version :10

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_056470.1
• Gene: ZNF337 / 26152
• HGNCID: 15809
• Length: 751
• Species: Homo sapiens
• Alignment Length: 261
• Identity: 69/261 - (26%)
• Similarity: 95/261 - (36%)
• Gaps: 54/261 - (20%)

  Fly   168 TGSSEKLQALTPPMDV-TPPKSPAKSSQ---SNIEPEKEHDQMSNSSEDMKYM------------ 216
            |...::.:..|.||.. :||...|.||:   |.:|.|....|..|.:|..|.:
Human   117 TAEGQEKEKSTKPMAFSSPPLRHAVSSRRRNSVVEIESSQGQRENPTEIDKVLKGIENSRWGAFK 181

  Fly   217 -AESEDDDTNIRMPI------------------------------YNSHGKMKNYKCKTCGVVAI 250
             ||...|.:...|.|                              .|:|...|:|.|..||....
Human   182 CAERGQDFSRKMMVIIHKKAHSRQKLFTCRECHQGFRDESALLLHQNTHTGEKSYVCSVCGRGFS 246

  Fly   251 TKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSH 315
            .|.:...|.||| ..:|...|..|......|.:|..|.|.|..:||::|.:|.....:||..|.|
Human   247 LKANLLRHQRTH-SGEKPFLCKVCGRGYTSKSYLTVHERTHTGEKPYECQECGRRFNDKSSYNKH 310

  Fly   316 RKSHSSVYQYRCADC--DYATKYCHSFKLHLRKY-GHKPGMVLD-EDGTPNPSLVIDVYGTRRGP 376
            .|:||....:.|.:|  .|..|  ..|.:|.|.: |.||....: ..|..|.|.:|....|..|.
Human   311 LKAHSGEKPFVCKECGRGYTNK--SYFVVHKRIHSGEKPYRCQECGRGFSNKSHLITHQRTHSGE 373

  Fly   377 K 377
            |
Human   374 K 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:463886	8/24 (33%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..345	CDD:275368	6/19 (32%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZNF337	NP_056470.1	KRAB	12..71	CDD:214630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..163		14/45 (31%)
		C2H2 Zn finger	182..202	CDD:275368	5/19 (26%)
		C2H2 Zn finger	210..230	CDD:275368	1/19 (5%)
		COG5048	234..626	CDD:227381	46/144 (32%)
		C2H2 Zn finger	238..258	CDD:275368	6/19 (32%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		C2H2 Zn finger	322..342	CDD:275368	7/21 (33%)
		C2H2 Zn finger	350..370	CDD:275368	4/19 (21%)
		C2H2 Zn finger	378..398	CDD:275368
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368
		C2H2 Zn finger	462..482	CDD:275368
		C2H2 Zn finger	490..510	CDD:275368
		C2H2 Zn finger	518..538	CDD:275368
		C2H2 Zn finger	546..566	CDD:275368
		C2H2 Zn finger	574..594	CDD:275368
		C2H2 Zn finger	602..622	CDD:275368
		C2H2 Zn finger	630..650	CDD:275368
		C2H2 Zn finger	658..679	CDD:275368
		C2H2 Zn finger	687..707	CDD:275368
		zf-H2C2_2	699..724	CDD:463886
		C2H2 Zn finger	715..735	CDD:275368