Protein Alignment hb and IKZF2

DIOPT Version :10

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_011509104.1
• Gene: IKZF2 / 22807
• HGNCID: 13177
• Length: 533
• Species: Homo sapiens
• Alignment Length: 642
• Identity: 126/642 - (19%)
• Similarity: 220/642 - (34%)
• Gaps: 203/642 - (31%)

  Fly   174 LQALTP------PMDVTPPKSPAKSSQSNIEPEKE----------HDQMSNSSEDMKYMAESEDD 222
            |.:.||      |..:|...|.....||:.|.:::          ||:.|:..|.:...:|..|:
Human    36 LTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEVADN 100

  Fly   223 --------DTNIRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTE 279
                    :..||:|    :||:   ||..||:|.|.......|.|:| ..::...|.:|.....
Human   101 RKVQELQGEGGIRLP----NGKL---KCDVCGMVCIGPNVLMVHKRSH-TGERPFHCNQCGASFT 157

  Fly   280 FKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHL 344
            .|.:|..||:.|..:|||:|..|||.|..:..|..|.::||....::|..|..:.|...|.:.|.
Human   158 QKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHK 222

  Fly   345 RKYGHKPGMVLDEDGTPNPSLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKSNVAAVAPQQQQSQ 409
            .:                                            ..:...||:..|..|..|.
Human   223 ER--------------------------------------------CHNYLQNVSMEAAGQVMSH 243

  Fly   410 PAQPVATSQLSAALQGFPLVQGNSAPPAASPVLPLPASPAKSVASVEQTPSLPSPANLLPPLASL 474
            ...|:...:                                     ||.|.:
Human   244 HVPPMEDCK-------------------------------------EQEPIM------------- 258

  Fly   475 LQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSDNEEEEQDDEYERKSV- 538
               :.|::..|:           ::.||:.:|:..|       .:::|...::...::..|.|.
Human   259 ---DNNISLVPF-----------ERPAVIEKLTGNM-------GKRKSSTPQKFVGEKLMRFSYP 302

  Fly   539 DSAMDLSQGTPVKEDEQQQQPQQPLAMNLKV----EEEATPLMSSSNASRRKGRVLKLDTLLQLR 599
            |...|::. |..||.|..|......|:|..:    .|...|||....::     :.::..::...
Human   303 DIHFDMNL-TYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPST-----IAEVAPVISSA 361

  Fly   600 SEAMTSPEQLKVPSTPMPTASS-------PIAGRKP--MPEEHCSGTSSADESMETAHVPQANTS 655
            ...:..|.:::.|.: ..||.|       ||:..:|  .|:|..:..|              |:.
Human   362 YSQVYHPNRIERPIS-RETADSHENNMDGPISLIRPKSRPQEREASPS--------------NSC 411

  Fly   656 ASSTASSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPPSG---TPAAAGAI------------- 704
            ..||.|.|.:..:.|  ..|:.:.|.....:.:.:......   |.|..|::
Human   412 LDSTDSESSHDDHQS--YQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQ 474

  Fly   705 ---YECKYCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS 758
               ::|::|.:.|.|.|:||||||.|...|..:||:||.:.........|:.|..|:
Human   475 IRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHT 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:463886	12/24 (50%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..345	CDD:275368	5/17 (29%)
		C2H2 Zn finger	707..727	CDD:275371	11/19 (58%)
		C2H2 Zn finger	735..757	CDD:275371	6/21 (29%)
IKZF2	XP_011509104.1	C2H2 Zn finger	121..141	CDD:275368	7/19 (37%)
		zf-H2C2_2	134..158	CDD:463886	5/24 (21%)
		C2H2 Zn finger	149..169	CDD:275368	6/19 (32%)
		zf-H2C2_2	161..186	CDD:463886	12/24 (50%)
		C2H2 Zn finger	177..197	CDD:275368	7/19 (37%)
		C2H2 Zn finger	205..226	CDD:275368	5/64 (8%)