Protein Alignment hb and Ikzf2

DIOPT Version :10

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_011236806.1
• Gene: Ikzf2 / 22779
• MGIID: 1342541
• Length: 550
• Species: Mus musculus
• Alignment Length: 709
• Identity: 143/709 - (20%)
• Similarity: 227/709 - (32%)
• Gaps: 264/709 - (37%)

  Fly   122 HLMGGFNPLTPPGLPNPMQHFYGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPPMDVTPP 186
            ::..|.|.|:|.|     :|                    |.:|:...||........|..:|..
Mouse    32 YITSGDNELSPEG-----EH--------------------ANMAIDLTSSTPNGQHASPSHMTST 71

  Fly   187 KSPAKSSQSNIEPEKE----------HDQMSNSSEDMKYMAESEDD--------DTNIRMPIYNS 233
            .|.....||:.|.:::          ||:.|:..|.:...:|..|:        :..||:|
Mouse    72 NSVKLEMQSDEECDRQPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQDLQGEGGIRLP---- 132

  Fly   234 HGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQ 298
            :||:   ||..||:|.|.......|.|:| ..::...|.:|......|.:|..||:.|..:|||:
Mouse   133 NGKL---KCDVCGMVCIGPNVLMVHKRSH-TGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFK 193

  Fly   299 CDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVLDEDGTPNP 363
            |..|||.|..:..|..|.::||....::|..|..:.|...|.:.|..:
Mouse   194 CPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKER----------------- 241

  Fly   364 SLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKSNVAAVAPQQQQSQPAQPVATSQLSAALQGFPL 428
                                       ..:...||:..|..|..|....|:...:
Mouse   242 ---------------------------CHNYLQNVSMEAAGQVMSHHVPPMEDCK---------- 269

  Fly   429 VQGNSAPPAASPVLPLPASPAKSVASVEQTPSLPSPANLLPPLASLLQQNRNMAFFPYWNLNLQM 493
                                       ||.|.:                :.|::..|:
Mouse   270 ---------------------------EQEPIM----------------DNNISLVPF------- 284

  Fly   494 LAAQQQAAVLAQLSPRMREQLQQQNQQQSDNEEEEQDDEYERKSVDSAMDLSQGTPVKEDEQQ-- 556
                ::.||:.:|:..|.                      :|||         .||.|...::
Mouse   285 ----ERPAVIEKLTANMG----------------------KRKS---------STPQKFVGEKLM 314

  Fly   557 --QQPQQPLAMNLKVEEEATPLMSS-------SNASRRKGRVLKLDTLLQLRSEAMTSPEQLKVP 612
              ..|.....|||..|:|| .||.|       :||            :..|.:||: .|.....|
Mouse   315 RFSYPDIHFDMNLTYEKEA-ELMQSHMMDQAINNA------------ITYLGAEAL-HPLMQHAP 365

  Fly   613 ST---PMPTASS-------PIAGRKPMPEEHCSGTSSADESMETAHV--------PQ------AN 653
            ||   ..|..||       |....:|:..|    ||.:.|:.....:        ||      :|
Mouse   366 STIAEVAPVISSAYSQVYHPNRIERPISRE----TSDSHENNMDGPISLIRPKSRPQEREASPSN 426

  Fly   654 TSASSTASSSGNSSNASSNSNGNSSSNSSSNGTTSAV---AAPPSGTPAAAGAI----------- 704
            :...||.|.|.:....|  ..||.:.|.....:.:.:   ......|.|..|::
Mouse   427 SCLDSTDSESSHDDRQS--YQGNPALNPKRKQSPAYMKEDVKALDATKAPKGSLKDIYKVFNGEG 489

  Fly   705 -----YECKYCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS 758
                 ::|::|.:.|.|.|:||||||.|...|..:||:||.:.........|:.|..|:
Mouse   490 EQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHT 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	7/19 (37%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:463886	12/24 (50%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..345	CDD:275368	5/17 (29%)
		C2H2 Zn finger	707..727	CDD:275371	11/19 (58%)
		C2H2 Zn finger	735..757	CDD:275371	6/21 (29%)
Ikzf2	XP_011236806.1	C2H2 Zn finger	138..158	CDD:275368	7/19 (37%)
		zf-H2C2_2	151..175	CDD:463886	5/24 (21%)
		C2H2 Zn finger	166..186	CDD:275368	6/19 (32%)
		zf-H2C2_2	178..203	CDD:463886	12/24 (50%)
		C2H2 Zn finger	194..214	CDD:275368	7/19 (37%)
		zf-H2C2_2	210..231	CDD:463886	5/20 (25%)
		C2H2 Zn finger	222..243	CDD:275368	5/64 (8%)