DRSC/TRiP Functional Genomics Resources

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Protein Alignment hb and Rest

DIOPT Version :9

Sequence 1:NP_731267.1 Gene:hb / 41032 FlyBaseID:FBgn0001180 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_035393.2 Gene:Rest / 19712 MGIID:104897 Length:1082 Species:Mus musculus


Alignment Length:987 Identity:168/987 - (17%)
Similarity:267/987 - (27%) Gaps:439/987 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 PNPM------QHFYGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKSSQ 194
            |.|:      ...|..|..|:|:         .|||.....|.|.:    |....|.:..|:|.:
Mouse   116 PQPVFEASAAPEIYSANKDPAPE---------TPVAEDKCRSSKAK----PFRCKPCQYEAESEE 167

  Fly   195 SNIEPEKEHDQ----MSNSSEDMKYMAESEDD-------------------DTNIRMPIYNSHGK 236
            ..:...:.|..    :..|:|......||...                   :|| |...|.:|.|
Mouse   168 QFVHHIRIHSAKKFFVEESAEKQAKAWESGSSPAEEGEFSKGPIRCDRCGYNTN-RYDHYMAHLK 231

  Fly   237 --------MKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPK-------------------- 273
                    .:.|||..|....:::..:..|.|.|. |.|:..|.|                    
Mouse   232 HHLRAGENERIYKCIICTYTTVSEYHWRKHLRNHF-PRKVYTCSKCNYFSDRKNNYVQHVRTHTG 295

  Fly   274 --------CPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSH-RKSHSSVYQYRCAD 329
                    ||:.:..|.||..|:|.|..:|||:||:|:|...|:..:..| |:.|:......|..
Mouse   296 ERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVHNGPKPLNCPH 360

  Fly   330 CDYATKYCHSFKLHLR------------------------------------------------- 345
            |||.|....:||.|:.                                                 
Mouse   361 CDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKT 425

  Fly   346 ------------------------------KYGHKPGMVLDEDGT----PNPSL-VIDV------ 369
                                          |...||...:.:|.:    |..|: |:.|      
Mouse   426 KKREADLLNNAVSNEKMENEQTKTKGDVSGKKNEKPVKAVGKDASKEKKPGSSVSVVQVTTRTRK 490

  Fly   370 ----------------------------------------------------------------- 369
                                                                             
Mouse   491 SAVAAETKAAEVKHTDGQTGNNPEKPCKAKKNKRKKDAEAHPSEEPVNEGPVTKKKKKSECKSKI 555

  Fly   370 -------------------------YGTRRGP----KSKNGGPIASGG----------------- 388
                                     .||::.|    .||.||.:|..|                 
Mouse   556 GTNVPKGGGRAEERPGVKKQSASLKKGTKKTPPKTKTSKKGGKLAPKGMGQTEPSSGALAQVGVS 620

  Fly   389 ----------SGSGSRKSNVAA---------------------VAPQQQQSQPAQPVATSQLSAA 422
                      :||||.::.:.:                     |.|.|.:..||:|   .|:.|.
Mouse   621 PDPALIQAEVTGSGSSQTELPSPMDIAKSEPAQMEVSLTGPPPVEPAQMEPSPAKP---PQVEAP 682

  Fly   423 LQGFPLVQGNSAP----PAASPVLPLPASPAKSVASVEQTPSLPS----PANLLPPLASLLQQ-- 477
            ....|..:|.:.|    |...|..|...:|...:|.:|.:|:.||    |.::.||....|.|  
Mouse   683 TYPQPPQRGPAPPTGPAPPTGPAPPTEPAPPTGLAEMEPSPTEPSQKEPPPSMEPPCPEELPQAE 747

  Fly   478 --------------------------------------------------------NRNMAFFPY 486
                                                                    .:.::.   
Mouse   748 PPPMEDCQKELPSPVEPAQIEVAQTAPTQVQEEPPPVSEPPRVKPTKRSSLRKDRAEKELSL--- 809

  Fly   487 WNLNLQMLAAQQQAAVLAQLSPRMREQLQQQNQQQSD-----------NEEEEQDDEYERKSVDS 540
                |..:|.|:|..:...|.|....:|.:.|:...|           |..||...:.|..|.  
Mouse   810 ----LSEMARQEQVLMGVGLVPVRDSKLLKGNKSAQDPPAPPSPSPKGNSREETPKDQEMVSD-- 868

  Fly   541 AMDLSQGT---PVKEDEQQQQPQQPLAMNLKVEEEATPLMSSSNASRRKGRVLKLDTLLQLRSEA 602
                .:||   |:|:...::..:.|..: ..::|.|....|..|::..:|..        ..|:.
Mouse   869 ----GEGTIVFPLKKGGPEEAGESPAEL-AALKESARVSSSEQNSAMPEGGA--------SHSKC 920

  Fly   603 MTSPEQL-------KVPSTPM-PTASSPIAGRKPMPEEHCSGTSSADESMETAHVPQANTSASST 659
            .|....|       |..:.|| .:|:.|::  .|.|.......|.|  .:.:..:..|...:...
Mouse   921 QTGSSGLCDVDTEQKTDTVPMKDSAAEPVS--PPTPTVDRDAGSPA--VVASPPITLAENESQEI 981

  Fly   660 ASSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPP-----SGTPAAAGAIYE----CKYCDIFFK 715
            ....|..|:..|:.:.|.|..|..:|...|...||     :|....||.:.|    |.:||..|:
Mouse   982 DEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPTPPEATSKNGKAGLAGKVTEGEFVCIFCDRSFR 1046

  Fly   716 DAVLYTIHMGYH 727
            ....|:.|:..|
Mouse  1047 KEKDYSKHLNRH 1058

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
hbNP_731267.1 C2H2 Zn finger 242..262 CDD:275368 4/19 (21%)
C2H2 Zn finger 271..291 CDD:275368 9/47 (19%)
zf-H2C2_2 283..308 CDD:290200 12/24 (50%)
C2H2 Zn finger 299..319 CDD:275368 7/20 (35%)
C2H2 Zn finger 327..345 CDD:275368 8/17 (47%)
C2H2 Zn finger 707..727 CDD:275371 6/19 (32%)
C2H2 Zn finger 735..757 CDD:275371