DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hb and Peg3

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_017177518.1	Gene:	Peg3 / 18616	MGIID:	104748	Length:	1652	Species:	Mus musculus

Alignment Length:	649	Identity:	131/649 - (20%)
Similarity:	214/649 - (32%)	Gaps:	174/649 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 PPMDVTPPKSPAKSSQSNIEPEKE-------HDQMSNSSEDMKYMAESEDDDTNIRMPIYNSHGK 236
            |..|....|.|......:.||..|       |.:.|:..|.:        :|..|:..:...|.|
Mouse  1108 PHGDEPHDKEPIDQEMRSEEPHSEESHGDEPHGEESHGQEKV--------EDATIQASVSEEHQK 1164

  Fly   237 MKN----YKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHI-------RK 290
            ...    |:|:.||:......|..:|..||.:  |.|...:     |:.|. |.|.       :|
Mouse  1165 DDAGDAIYECQDCGLGFTDLNDLTSHQDTHSR--KALVDSR-----EYAHS-EVHAHSVSEFEKK 1221

  Fly   291 HKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGMVL 355
            ...:|.::|.||..:.::.|:|..|::.|..       |..|:.|.|....:.|.....:....:
Mouse  1222 CSGEKLYECPKCGESFIHSSLLFEHQRVHEQ-------DQLYSVKACDDAFIALLPVRPRRNCTV 1279

  Fly   356 DEDGTPNPSLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKSNVAAVAPQQQQSQPAQPVATSQLS 420
            :.    ||::              :|..|.....|.|...|  :|:....:|.:..:.:..|:||
Mouse  1280 ER----NPAV--------------SGSAIRCRQCGQGFIHS--SALNEHMRQHRDNEIMEQSELS 1324

  Fly   421 --AALQGFPLV--QGNSAPPAASPVL-----------------------PLPASPAKSVASVEQT 458
              ..:||..|.  ||:..........                       |....|:.:.||.
Mouse  1325 DEIFIQGLALTEYQGSETEEKLFECTICGECFFTAKQLGDHHTKVHKDEPYEYGPSYTHASF--- 1386

  Fly   459 PSLPSPANLLPPL-------ASLLQQN---RNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQ 513
              |..|.....||       .|.|...   ..|.|.|......:::||..|......|.|:...:
Mouse  1387 --LTEPLRKHIPLYECKDCGQSFLDDTVIAERMVFHPEREGGSEIVAATAQEVEANVLIPQEVLR 1449

  Fly   514 LQQQNQQQSDNEEEEQDDEYE--RKSVDSA-----MDLSQGTPVKEDEQQQQP----QQPLAMNL 567
            :|..|.:.::.|.|..:.|.|  ...|::|     .:...|...:.|.:.:||    :||
Mouse  1450 IQGSNAEAAEPEVEAAEPEVEAAEPEVEAAEPNGEAEGPDGEAAEPDGEAEQPNGEAEQP----- 1509

  Fly   568 KVEEEATPLMSSSNASRRKGRVLKLDTLLQLRSEAMTSPEQLKVPSTPMPTASSPIAGRKPMPEE 632
                       :.:|....|..:: |.     .|....||:  ....|...|..|.......|||
Mouse  1510 -----------NGDADEPDGAGIE-DP-----EERADEPEE--DVEEPEGDADEPDGADIEDPEE 1555

  Fly   633 HCSGTSSADESMETAHVPQAN--TSASSTASSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPPS 695
                 ...|:.:|... |..|  ..|.:.||||....:..|::              |.:...|:
Mouse  1556 -----EGEDQEIEVEE-PYYNCHECAETFASSSAFGEHLKSHA--------------SVIIFEPA 1600

  Fly   696 GTPAAAGAIYECKYCDIFFKDAVLYTIHMGYHSCDD-VFKCNMCGEKCDGPVGLFVHMARNAHS 758
            ..|..         |..:.:.|  .|...|....|| .|||::||:..:..:.|..|  :|:|:
Mouse  1601 NAPGE---------CSGYIERA--STSAGGAEQADDKYFKCDVCGQLFNDRLSLARH--QNSHT 1651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	4/26 (15%)
		zf-H2C2_2	283..308	CDD:290200	7/31 (23%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..345	CDD:275368	4/17 (24%)
		C2H2 Zn finger	707..727	CDD:275371	4/19 (21%)
		C2H2 Zn finger	735..757	CDD:275371	6/21 (29%)
Peg3	XP_017177518.1	C2H2 Zn finger	408..428	CDD:275368
		zf-C2H2	459..481	CDD:333835
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..652	CDD:275368
		zf-C2H2	931..953	CDD:333835
		C2H2 Zn finger	933..953	CDD:275368
		PHA03169	943..>1161	CDD:223003	12/60 (20%)
		C2H2 Zn finger	1174..1194	CDD:275368	5/19 (26%)
		zf-C2H2	1228..1250	CDD:333835	6/21 (29%)
		C2H2 Zn finger	1230..1250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1292..1312	CDD:275368	4/21 (19%)
		C2H2 Zn finger	1349..1370	CDD:275368	0/20 (0%)
		C2H2 Zn finger	1571..1591	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1630..1650	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930