DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hb and hbl-1

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001041243.1	Gene:	hbl-1 / 180848	WormBaseID:	WBGene00001824	Length:	982	Species:	Caenorhabditis elegans

Alignment Length:	896	Identity:	218/896 - (24%)
Similarity:	339/896 - (37%)	Gaps:	280/896 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TATTNYEQHNA--------------WYNSMF--AANIKQEP----GHHLDGNS--VASSPRQSPI 49
            |.:.|.|:.|:              .:..:|  ||.|::..    |....|.|  :...|::..:
Worm   221 TQSANVERSNSPSIEEALLLTLSQQQFAEVFAEAAKIRKSSSESIGFQRSGTSAFLNIEPKEMSM 285

  Fly    50 PSTNHLEQFLKQQQQQLQQQPMDTLCA-MTPS-------------------PSQNDQN------- 87
            .|.|:          ..::.|..|:.| .||:                   |:||.|.
Worm   286 SSANN----------NNEEAPASTVSACSTPTTTTSASFCRPPGLGPVALPPTQNGQTPMLVCPI 340

  Fly    88 ------SLQHYDANLQ---QQLLQQQQYQQHFQAAQQQHHHHHH-----LMGGFNPLTPPGLPNP 138
                  |..|:::::.   ........|....:...::|....|     |..||.       ..|
Worm   341 CGFMCPSKFHFNSHMNTHGDHQCSMCDYTSRTEGRLKKHMRESHTVEEQLRAGFE-------SEP 398

  Fly   139 MQHFYGG--NLRPSPQPTPTS--------ASTIAPV------AVATGSSEK----LQALTPPMDV 183
            .:.....  ||..|...:.||        ::|:|.:      ||::.|:.:    |.|||..|..
Worm   399 AKESASSPKNLSLSKDGSATSPINEIFNLSTTMASILDSTNNAVSSTSTTEQPSALSALTLDMSS 463

  Fly   184 TPP--KSPAKSSQSNIEPEKEHDQMSNSSEDMKYMAE---------------------SEDDDTN 225
            ||.  .:.|.||..    ....||:...||:..:|.|                     |.:..:|
Worm   464 TPSLLSTLAHSSFG----VSALDQIKAISENPSFMPEGGINLASALGVVSNAIKGDTPSPEKQSN 524

  Fly   226 --IRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHI 288
              .|.   :|.||:|.:|||.||..:::|.|.|||.|||:..:|.|.|..|.||||:|||||||.
Worm   525 GECRR---SSSGKIKIFKCKQCGHQSLSKDDQWAHARTHIPAEKQLNCQHCNFVTEYKHHLEYHY 586

  Fly   289 RKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKYGHKPGM 353
            |.|...|||||.||:|.||||||||||.|||::.||:||.||.||||||||.||||:||.|
Worm   587 RNHIGSKPFQCKKCAYNCVNKSMLNSHMKSHTNHYQFRCMDCTYATKYCHSLKLHLKKYNH---- 647

  Fly   354 VLDEDGTPNPSLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKSNV----AAVAPQQQQSQPAQPV 414
                               ||.|:    |...|||..|....|:.    :.:..|:.:::..:||
Worm   648 -------------------RRVPE----GIEMSGGDSSPPFTSDATITFSPLMKQEIKTETVEPV 689

  Fly   415 ATSQLSAALQGFPL--VQGNSAPPAASPVL------------------PLPASPAKSVASVEQTP 459
                 ::..|.||.  :.||.....|:.:|                  ||..|....|||.....
Worm   690 -----TSIAQPFPFNPMMGNHGLNFANHMLLNKHLDVGLMGLRNSVMSPLKCSACDFVASSADEK 749

  Fly   460 SLPSPANLL------PPLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQN 518
            ...|.:::|      ..:|||           |.:|||..         .:.::|.....|:..:
Worm   750 MRHSMSHILNSSNVPTSIASL-----------YNSLNLPS---------FSHVAPDNDNALESMD 794

  Fly   519 ---QQQSDNEEEEQDDEYERKSVDSAMDLSQGTPVKEDEQQQQPQQPLAM---NLKVEEEATPLM 577
               :...||..|....|...:..|||:..:..:.:...:::.:..:.|::   :.:.....:| |
Worm   795 CDVKIDDDNITESHCYEEMDQGSDSAVSPTGSSQISSGDEETKKCKSLSLEQISARANGNNSP-M 858

  Fly   578 SSSNASRRKGRVLKLDTLLQLRSEAMTSP-EQLKVPSTPMPTASSPIAGRKPMPEEHCSGTSSAD 641
            |:.:|..:.|         :...:|..|| :...|||.|: .:||.:|   |:|
Worm   859 SNDSAMEKDG---------ESADDAPHSPSDTTSVPSPPL-HSSSIVA---PIP----------- 899

  Fly   642 ESMETAHVPQANTSASSTASSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAAGAIYE 706
                  ..||.|....|..:.:                        |.:....:..|:|    :.
Worm   900 ------ITPQPNEFLQSILAQA------------------------SLLGPLLANRPSA----FY 930

  Fly   707 CKYCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAH 757
            |.:|.|.|....:...||.:|:..:.|.|:.|..:....:...:||.:..|
Worm   931 CDHCKIPFDTQQVLDSHMRFHTPGNPFMCSDCQYQAFNELSFALHMYQARH 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	10/19 (53%)
		C2H2 Zn finger	271..291	CDD:275368	14/19 (74%)
		zf-H2C2_2	283..308	CDD:290200	16/24 (67%)
		C2H2 Zn finger	299..319	CDD:275368	15/19 (79%)
		C2H2 Zn finger	327..345	CDD:275368	14/17 (82%)
		C2H2 Zn finger	707..727	CDD:275371	6/19 (32%)
		C2H2 Zn finger	735..757	CDD:275371	4/21 (19%)
hbl-1	NP_001041243.1	C2H2 Zn finger	338..358	CDD:275368	2/19 (11%)
		C2H2 Zn finger	363..384	CDD:275368	2/20 (10%)
		C2H2 Zn finger	569..589	CDD:275368	14/19 (74%)
		zf-H2C2_2	581..602	CDD:290200	14/20 (70%)
		C2H2 Zn finger	597..617	CDD:275368	15/19 (79%)
		zf-H2C2_2	609..634	CDD:290200	17/24 (71%)
		C2H2 Zn finger	625..643	CDD:275368	14/17 (82%)
		C2H2 Zn finger	931..951	CDD:275368	6/19 (32%)
		C2H2 Zn finger	959..982	CDD:275368	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165810
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	217	1.000	Inparanoid score	I2319
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003075
OrthoInspector	1	1.000	-	-		oto20764
orthoMCL	1	0.900	-	-		OOG6_115532
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16894
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910