DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and ZSCAN29

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001359009.1	Gene:	ZSCAN29 / 146050	HGNCID:	26673	Length:	852	Species:	Homo sapiens

Alignment Length:	215	Identity:	57/215 - (26%)
Similarity:	79/215 - (36%)	Gaps:	45/215 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 ATGSSEKLQALTPPMDVTPPKSPAK--SSQSNIEPEKEHDQMSNSSEDMKYMAESEDDDTNIRMP 229
            |..|.||...||     .|.||.::  |.|.....|:.:          ||:..|:....|..:.
Human   618 AKTSGEKRGKLT-----LPEKSLSEVLSQQRPCLGERPY----------KYLKYSKSFGPNSLLM 667

  Fly   230 IYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHM--KPDKILQCPK-----CPFVTEFKHH---- 283
            ...||.....|||..||...........|.|.|.  ||.|.|.|.|     ..|:|..:.|
Human   668 HQVSHQVENPYKCADCGKSFSRSARLIRHRRIHTGEKPYKCLDCGKSFRDSSNFITHRRIHTGEK 732

  Fly   284 ----------------LEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCDY 332
                            |..|.|.|..:||:||::|..:..|.|..::||:.|:....:.|.||..
Human   733 PYQCGECGKCFNQSSSLIIHQRTHTGEKPYQCEECGKSFNNSSHFSAHRRIHTGERPHVCPDCGK 797

  Fly   333 ATKYCHSFKLHLRKY-GHKP 351
            :.......:.|.|.: |.||
Human   798 SFSKSSDLRAHHRTHTGEKP 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	8/44 (18%)
		zf-H2C2_2	283..308	CDD:290200	10/44 (23%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..345	CDD:275368	4/17 (24%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZSCAN29	NP_001359009.1	SCAN	14..124	CDD:128708
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..182
		Myb_DNA-bind_4	245..330	CDD:372747
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..400
		Myb_DNA-bind_4	408..493	CDD:372747
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..625		3/6 (50%)
		COG5048	<630..838	CDD:227381	51/198 (26%)
		C2H2 Zn finger	680..700	CDD:275368	5/19 (26%)
		C2H2 Zn finger	708..728	CDD:275368	5/19 (26%)
		C2H2 Zn finger	736..756	CDD:275368	3/19 (16%)
		C2H2 Zn finger	764..784	CDD:275368	6/19 (32%)
		C2H2 Zn finger	792..812	CDD:275368	5/19 (26%)
		C2H2 Zn finger	820..840	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930