DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and ZNF641

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_689533.2	Gene:	ZNF641 / 121274	HGNCID:	31834	Length:	438	Species:	Homo sapiens

Alignment Length:	270	Identity:	60/270 - (22%)
Similarity:	93/270 - (34%)	Gaps:	72/270 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 GGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKSSQSNIEPEKEHDQ--- 205
            ||..:..|.|.......|..|.. ||...:.:..||.::..||:..:..|:..:....|||:
Human   164 GGEEQWVPDPQDLEERDILRVTY-TGDGSEHEGDTPELEAEPPRMLSSVSEDTVLWNPEHDESWD 227

  Fly   206 -MSNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNYKCKTCGVVAITKVDFWAHTRTHMKPDKIL 269
             |.:||..|            :..|.:.......|..|.|                   :.|.:|
Human   228 SMPSSSRGM------------LLGPPFLQEDSFSNLLCST-------------------EMDSLL 261

  Fly   270 Q---CPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNKSMLNSHRKSHSSVYQYRCADCD 331
            :   ||:|.....:..||..|.:.|..::|:.|.||..|...:..|..|:|:|......||::|.
Human   262 RPHTCPQCGKQFVWGSHLARHQQTHTGERPYSCLKCEKTFGRRHHLIRHQKTHLHDKTSRCSECG 326

  Fly   332 YATKYCHSFKLHLRKYG--HKPGMVLDEDGTPNPSLVIDVYGTRRGPKSKNGGPIASGGSGSGSR 394
            ...: |:|   ||..:.  |..|                        ||..|..:   |...|:|
Human   327 KNFR-CNS---HLASHQRVHAEG------------------------KSCKGQEV---GESPGTR 360

  Fly   395 KSNVAAVAPQ 404
            |...|...|:
Human   361 KRQRAPPVPK 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	2/19 (11%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:290200	9/24 (38%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..345	CDD:275368	5/17 (29%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZNF641	NP_689533.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		KRAB	109..170	CDD:214630	2/5 (40%)
		KRAB	109..149	CDD:279668
		Transactivation	171..265		24/125 (19%)
		COG5048	227..>372	CDD:227381	44/206 (21%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	278..303	CDD:290200	9/24 (38%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		C2H2 Zn finger	322..342	CDD:275368	6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	345..367		9/48 (19%)
		COG5048	351..>430	CDD:227381	6/23 (26%)
		zf-C2H2	372..394	CDD:278523
		C2H2 Zn finger	374..394	CDD:275368
		zf-H2C2_2	386..411	CDD:290200
		C2H2 Zn finger	402..422	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..438
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156899
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930