DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hb and ZNF274

DIOPT Version :9

Sequence 1:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_598009.1	Gene:	ZNF274 / 10782	HGNCID:	13068	Length:	653	Species:	Homo sapiens

Alignment Length:	368	Identity:	72/368 - (19%)
Similarity:	123/368 - (33%)	Gaps:	97/368 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WETTATTNYEQHNAWYNSMFAANIKQEPGHHLDGNSVASSPRQSPIPSTNHLEQFLKQQQQQLQQ 68
            ||||..          |...|.|              :..|.:.|.||.            ::|:
Human   328 WETTLE----------NKELAPN--------------SDIPEEEPAPSL------------KVQE 356

  Fly    69 QPMDTLCAMTPSPSQNDQNSLQHYDANLQQQLLQQQQYQQHFQAAQQQHHHHHHLMGG-----FN 128
            ...|  ||::.:.....|..:|    .:|..:|:|.:..|.....|::|..:......     .|
Human   357 SSRD--CALSSTLEDTLQGGVQ----EVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGALDTN 415

  Fly   129 PLTPPGLPNPMQHFYGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQALTPPMDVTPPKSPAKSS 193
            .::...:.||...                        ..:|:.:..|.|   :...||:...:..
Human   416 QVSLQKIDNPESQ------------------------ANSGALDTNQVL---LHKIPPRKRLRKR 453

  Fly   194 QSNIEPEK------------EHDQMSNSSEDMKYMAESEDDDTNIRMPIYNSHGKMKNYKCKTCG 246
            .|.::..|            |..:....:...|..:.|....|.||:     |...:..:|..||
Human   454 DSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQITFIRI-----HKGSQVCRCSECG 513

  Fly   247 VVAITKVDFWAHTRTHM--KPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNK 309
            .:......|..|.:.|.  :|.....|.| .||.  ...|..|.|.|..::||:|.:|..|..::
Human   514 KIFRNPRYFSVHKKIHTGERPYVCQDCGK-GFVQ--SSSLTQHQRVHSGERPFECQECGRTFNDR 575

  Fly   310 SMLNSHRKSHSSVYQYRCADCDYATKYCHSFKLHLRKY-GHKP 351
            |.::.|.::|:....|:|.||..|.:.......|.|.: |.:|
Human   576 SAISQHLRTHTGAKPYKCQDCGKAFRQSSHLIRHQRTHTGERP 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	7/19 (37%)
		zf-H2C2_2	283..308	CDD:290200	9/24 (38%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..345	CDD:275368	5/17 (29%)
		C2H2 Zn finger	707..727	CDD:275371
		C2H2 Zn finger	735..757	CDD:275371
ZNF274	NP_598009.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..159
		SCAN	157..269	CDD:128708
		SCAN	157..245	CDD:280241
		KRAB	287..>327	CDD:214630
		KRAB	287..326	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..359		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..414		3/25 (12%)
		COG5048	<389..644	CDD:227381	52/265 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..485		3/36 (8%)
		C2H2 Zn finger	481..501	CDD:275368	5/24 (21%)
		C2H2 Zn finger	509..529	CDD:275368	5/19 (26%)
		zf-H2C2_2	521..546	CDD:290200	7/25 (28%)
		C2H2 Zn finger	537..557	CDD:275368	7/22 (32%)
		zf-H2C2_2	549..573	CDD:290200	9/23 (39%)
		zf-C2H2	563..585	CDD:278523	6/21 (29%)
		C2H2 Zn finger	565..585	CDD:275368	5/19 (26%)
		zf-C2H2	591..613	CDD:278523	7/21 (33%)
		C2H2 Zn finger	593..613	CDD:275368	6/19 (32%)
		zf-H2C2_2	605..630	CDD:290200	4/14 (29%)
		C2H2 Zn finger	621..641	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156897
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930