Protein Alignment hb and IKZF1

DIOPT Version :10

• Sequence 1: NP_731267.1
• Gene: hb / 41032
• FlyBaseID: FBgn0001180
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_011513360.1
• Gene: IKZF1 / 10320
• HGNCID: 13176
• Length: 563
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 148/699 - (21%)
• Similarity: 222/699 - (31%)
• Gaps: 286/699 - (40%)

  Fly   151 PQPTPTSASTIA---------PVAVATGSSE--KLQALTPPMDVTPPKSPAKS-SQSNIEPEKEH 203
            |.|.|...||.:         .|.|..|:.:  ...|:.|           || |.||::.|.:.
Human    54 PMPIPEDLSTTSGGQQSSKSDRVVVTYGADDFRDFHAIIP-----------KSFSPSNVKVETQS 107

  Fly   204 DQMS---------NSSEDMKYMAESEDDDTN----------------IRMPIYNSHGKMKNYKCK 243
            |:.:         ..:||:: |.::..:..|                ||:|    :||:   ||.
Human   108 DEENGRACEMNGEECAEDLR-MLDASGEKMNGSHRDQGSSALSGVGGIRLP----NGKL---KCD 164

  Fly   244 TCGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVN 308
            .||::.|.......|.|:| ..::..||.:|......|.:|..||:.|..:|||:|..|:|.|..
Human   165 ICGIICIGPNVLMVHKRSH-TGERPFQCNQCGASFTQKGNLLRHIKLHSGEKPFKCHLCNYACRR 228

  Fly   309 KSMLNSHRKSHSSVYQYRCADCDYATKY----------CHSF--------KLH------------ 343
            :..|..|.::||....::|..|..:.|.          ||::        .|:
Human   229 RDALTGHLRTHSVGKPHKCGYCGRSYKQRSSLEEHKERCHNYLESMGLPGTLYPVIKEETNHSEM 293

  Fly   344 ---LRKYGHKPGMVLD---------EDGTPNPSLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKS 396
               |.|.|.:..:|||         :...|...|         |.|..:..|..|..|.....:.
Human   294 AEDLCKIGSERSLVLDRLASNVAKRKSSMPQKFL---------GDKGLSDTPYDSSASYEKENEM 349

  Fly   397 NVAAVAPQQQQSQPAQPVATSQLSA-ALQGFPLVQGNSAPPAASPVLPLPASPAKSVASVEQTPS 460
            ..:.|..|...:      |.:.|.| :|:  ||||   .||..|.|:|: .||.
Human   350 MKSHVMDQAINN------AINYLGAESLR--PLVQ---TPPGGSEVVPV-ISPM----------- 391

  Fly   461 LPSPANLLPPLASLLQQNRNMAFFPYWNLNLQMLAAQQQAAV-------LAQLSPRMRE-----Q 513
                ..|..|||....::.:.|               |.:||       .|:|.|..||     .
Human   392 ----YQLHKPLAEGTPRSNHSA---------------QDSAVENLLLLSKAKLVPSEREASPSNS 437

  Fly   514 LQQQNQQQSDNEEEEQDDEYERKSVDSAMDLSQGTPVKEDEQQQQPQQPLAMNLKVEEEATPLMS 578
            .|.....:|:|||:.....|....:                   .|.....::||.|..|..|
Human   438 CQDSTDTESNNEEQRSGLIYLTNHI-------------------APHARNGLSLKEEHRAYDL-- 481

  Fly   579 SSNASRRKGRVLKLDTLLQLRSEAMTSPEQLKVPSTPMPTASSPIAGRKPMPEEHCSGTSSADES 643
                               ||:.:..|.:.|:|.||                    ||     |.
Human   482 -------------------LRAASENSQDALRVVST--------------------SG-----EQ 502

  Fly   644 METAHVPQANTSASSTASSSGNSSNASSNSNGNSSSNSSSNGTTSAVAAPPSGTPAAAGAIYECK 708
            |:                                                          :|:|:
Human   503 MK----------------------------------------------------------VYKCE 509

  Fly   709 YCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAH 757
            :|.:.|.|.|:||||||.|...|.|:|||||...........|:.|..|
Human   510 HCRVLFLDHVMYTIHMGCHGFRDPFECNMCGYHSQDRYEFSSHITRGEH 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	271..291	CDD:275368	6/19 (32%)
		zf-H2C2_2	283..308	CDD:463886	11/24 (46%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..345	CDD:275368	6/50 (12%)
		C2H2 Zn finger	707..727	CDD:275371	11/19 (58%)
		C2H2 Zn finger	735..757	CDD:275371	7/21 (33%)
IKZF1	XP_011513360.1	C2H2 Zn finger	163..183	CDD:275368	6/19 (32%)
		zf-H2C2_2	176..200	CDD:463886	6/24 (25%)
		COG5048	187..>343	CDD:227381	37/164 (23%)
		C2H2 Zn finger	191..211	CDD:275368	6/19 (32%)
		zf-H2C2_2	203..228	CDD:463886	11/24 (46%)
		C2H2 Zn finger	219..239	CDD:275368	6/19 (32%)
		zf-H2C2_2	235..256	CDD:463886	5/20 (25%)
		C2H2 Zn finger	247..268	CDD:275368	3/20 (15%)