Protein Alignment CG8036 and TKL1

DIOPT Version :9

• Sequence 1: NP_649812.2
• Gene: CG8036 / 41027
• FlyBaseID: FBgn0037607
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_015399.1
• Gene: TKL1 / 856188
• SGDID: S000006278
• Length: 680
• Species: Saccharomyces cerevisiae
• Alignment Length: 608
• Identity: 175/608 - (28%)
• Similarity: 270/608 - (44%)
• Gaps: 78/608 - (12%)

  Fly    13 DLKDLA-QKLRIHSINATQASKSGHPTSCASIAEIMSVLFFQQLRLNLKHPRDPSSDRFILSKGH 76
            |:..|| ..:||.:::....:.||||.:...:|....|| :.|:|:|..:|...:.|||:||.||
Yeast     6 DIDKLAVSTIRILAVDTVSKANSGHPGAPLGMAPAAHVL-WSQMRMNPTNPDWINRDRFVLSNGH 69

  Fly    77 AAPILYAAWAEAGL-FPIADLNNLRKIDSDLEGHPTPRLNFIDVGTGSLGQGVAVGAGMAYVGKN 140
            |..:||:.....|. ..|.||...|::.|...|||...|..::|.||.||||::...|||....|
Yeast    70 AVALLYSMLHLTGYDLSIEDLKQFRQLGSRTPGHPEFELPGVEVTTGPLGQGISNAVGMAMAQAN 134

  Fly   141 ---------FDKADYRTYVVVGDGESAEGSIWESLHFAGHYKLDNLCVIFDVNRLGQSEATSLQH 196
                     |..:|..|||.:|||...||...|:...|||.||.||..|:|.|::....|||:..
Yeast   135 LAATYNKPGFTLSDNYTYVFLGDGCLQEGISSEASSLAGHLKLGNLIAIYDDNKITIDGATSISF 199

  Fly   197 KLDVYRDRLEAFGFNAVVVD--GHDVEELSKAFHCAAITKNKPTAIIAKTFKGRDFPNIE-DLDN 258
            ..||.: |.||:|:..:.|:  ..|:..::||...|.::|:|||.|...|..|  :.::. ...:
Yeast   200 DEDVAK-RYEAYGWEVLYVENGNEDLAGIAKAIAQAKLSKDKPTLIKMTTTIG--YGSLHAGSHS 261

  Fly   259 WHGKPLGDKAAEVVKHLE---GLIVNKNVKLTPKPV----PKTGAAPDVDINN--IKL------- 307
            .||.||   .|:.||.|:   |...:|:. :.|:.|    .||...|.|:.||  .||
Yeast   262 VHGAPL---KADDVKQLKSKFGFNPDKSF-VVPQEVYDHYQKTILKPGVEANNKWNKLFSEYQKK 322

  Fly   308 ---------------------SSPPAYKLGDS-IATRLAYGTALAKIGQNNLRVVALDGDTKNST 350
                                 |..|.|...|| :|||....|.|..:......::....|...|.
Yeast   323 FPELGAELARRLSGQLPANWESKLPTYTAKDSAVATRKLSETVLEDVYNQLPELIGGSADLTPSN 387

  Fly   351 FSDKLKNLDPQ-----------RYIECFIAEQNLVGVAVG-AACRRRTVAFVSTFATFFTRAFDQ 403
            .:...:.||.|           |||...|.|..:..:..| :|.......:..||..|.:.|...
Yeast   388 LTRWKEALDFQPPSSGSGNYSGRYIRYGIREHAMGAIMNGISAFGANYKPYGGTFLNFVSYAAGA 452

  Fly   404 IRMGAISQTNVNFVGSHCGCSIGEDGPSQMGLEDIAMFRTIPGSTIFYPSDAVSTERAVELAANT 468
            :|:.|:|...|.:|.:|....:|||||:...:|.:|.||::|...::.|:|......|.:.:..:
Yeast   453 VRLSALSGHPVIWVATHDSIGVGEDGPTHQPIETLAHFRSLPNIQVWRPADGNEVSAAYKNSLES 517

  Fly   469 KGV-CFIRTSRPNTCVIYDNEEPFTIGRGKVVRQKSSDEVLLIGAGITLYECLAAADQLEKNCIT 532
            |.. ..|..||.|...:..:........|.|::..::.:::|:..|..:...:.||..|....|.
Yeast   518 KHTPSIIALSRQNLPQLEGSSIESASKGGYVLQDVANPDIILVATGSEVSLSVEAAKTLAAKNIK 582

  Fly   533 VRVI---DPFTV--KPLDAELII 550
            .||:   |.||.  :||:..|.:
Yeast   583 ARVVSLPDFFTFDKQPLEYRLSV 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8036	NP_649812.2	PRK05899	8..624	CDD:235639	175/608 (29%)
		TPP_TK	19..270	CDD:238970	90/263 (34%)
		TPP_PYR_DXS_TK_like	324..478	CDD:132916	39/166 (23%)
		Transketolase_C	496..616	CDD:280875	16/60 (27%)
TKL1	NP_015399.1	tktlase_bact	9..664	CDD:272974	174/605 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I1168
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I994
Isobase	1	0.950	-	0	Normalized mean entropy	S1450
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		mtm9238
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1527
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.700