DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8036 and TKL2

DIOPT Version :9

Sequence 1:	NP_649812.2	Gene:	CG8036 / 41027	FlyBaseID:	FBgn0037607	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_009675.3	Gene:	TKL2 / 852414	SGDID:	S000000321	Length:	681	Species:	Saccharomyces cerevisiae

Alignment Length:	592	Identity:	160/592 - (27%)
Similarity:	254/592 - (42%)	Gaps:	78/592 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DLKDLA-QKLRIHSINATQASKSGHPTSCASIAEIMSVLFFQQLRLNLKHPRDPSSDRFILSKGH 76
            |:..|| ..||:.|::..::::||||.:...:|.:..|: |:|||.|..:....:.|||:||.||
Yeast     6 DIDKLAVSTLRLLSVDQVESAQSGHPGAPLGLAPVAHVI-FKQLRCNPNNEHWINRDRFVLSNGH 69

  Fly    77 AAPILYAAWAEAGL-FPIADLNNLRKIDSDLEGHPTPRLNFIDVGTGSLGQGVAVGAGMAYVGKN 140
            :..:||:.....|. :.|.||...|:::|...|||......:::.:|.||||::...|||....|
Yeast    70 SCALLYSMLHLLGYDYSIEDLRQFRQVNSRTPGHPEFHSAGVEITSGPLGQGISNAVGMAIAQAN 134

  Fly   141 FDK---------ADYRTYVVVGDGESAEGSIWESLHFAGHYKLDNLCVIFDVNRLGQSEATSLQH 196
            |..         :|..|:.:||||...||...|:...|||.:|.||...:|.|.:.....||...
Yeast   135 FAATYNEDGFPISDSYTFAIVGDGCLQEGVSSETSSLAGHLQLGNLITFYDSNSISIDGKTSYSF 199

  Fly   197 KLDVYRDRLEAFGFNAVVVD--GHDVEELSKAFHCAAITKNKPTAIIAKTFKGRDFPNIED-LDN 258
            ..||.: |.||:|:..:.||  ..|:|.:|.|...|.::|:|||.|...|..|  |.:::. ...
Yeast   200 DEDVLK-RYEAYGWEVMEVDKGDDDMESISSALEKAKLSKDKPTIIKVTTTIG--FGSLQQGTAG 261

  Fly   259 WHGKPLGDKAAEVVKHLE---GLIVNKNVKLTPKPV----PKTGAAPDVDIN--------NIKLS 308
            .||..|   .|:.||.|:   |...||:. :.|:.|    .||...|...:|        ..|..
Yeast   262 VHGSAL---KADDVKQLKKRWGFDPNKSF-VVPQEVYDYYKKTVVEPGQKLNEEWDRMFEEYKTK 322

  Fly   309 SPPAYKL-----------------------GDSIATRLAYGTALAKIGQNNLRVVALDGDTKNST 350
            .|...|.                       .|::|||......|..:.|....::....|...|.
Yeast   323 FPEKGKELQRRLNGELPEGWEKHLPKFTPDDDALATRKTSQQVLTNMVQVLPELIGGSADLTPSN 387

  Fly   351 FSDKLKNLDPQ-----------RYIECFIAEQNLVGVAVG-AACRRRTVAFVSTFATFFTRAFDQ 403
            .:.....:|.|           |||...:.|..:..:..| :|.......:..||..|.:.|...
Yeast   388 LTRWEGAVDFQPPITQLGNYAGRYIRYGVREHGMGAIMNGISAFGANYKPYGGTFLNFVSYAAGA 452

  Fly   404 IRMGAISQTNVNFVGSHCGCSIGEDGPSQMGLEDIAMFRTIPGSTIFYPSDAVSTERAVELA--- 465
            :|:.|:|...|.:|.:|....:|||||:...:|.:|..|.||...::.|:|...|..|...|
Yeast   453 VRLAALSGNPVIWVATHDSIGLGEDGPTHQPIETLAHLRAIPNMHVWRPADGNETSAAYYSAIKS 517

  Fly   466 ANTKGVCFIRTSRPNTCVIYDNEEPFTIGRGKVVRQKSSDEVLLIGAGITLYECLAAADQL-EKN 529
            ..|..|  :..||.|...:..:.....:..|.|:....:.:::|:..|..:...:.||.:| :..
Yeast   518 GRTPSV--VALSRQNLPQLEHSSFEKALKGGYVIHDVENPDIILVSTGSEVSISIDAAKKLYDTK 580

  Fly   530 CITVRVI 536
            .|..||:
Yeast   581 KIKARVV 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8036	NP_649812.2	PRK05899	8..624	CDD:235639	160/592 (27%)
		TPP_TK	19..270	CDD:238970	85/263 (32%)
		TPP_PYR_DXS_TK_like	324..478	CDD:132916	39/168 (23%)
		Transketolase_C	496..616	CDD:280875	10/42 (24%)
TKL2	NP_009675.3	tktlase_bact	9..665	CDD:272974	159/589 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I1168
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I994
Isobase	1	0.950	-	0	Normalized mean entropy	S1450
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		mtm9238
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1527
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.700