Protein Alignment CG8036 and Tktl1

DIOPT Version :9

• Sequence 1: NP_649812.2
• Gene: CG8036 / 41027
• FlyBaseID: FBgn0037607
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_113556.2
• Gene: Tktl1 / 83553
• MGIID: 1933244
• Length: 595
• Species: Mus musculus
• Alignment Length: 620
• Identity: 302/620 - (48%)
• Similarity: 403/620 - (65%)
• Gaps: 43/620 - (6%)

  Fly     6 PEAKTVQDLKDLAQKLRIHSINATQASKSGHPTSCASIAEIMSVLFFQQLRLNLKHPRDPSSDRF 70
            |:.||:|.|:|:|.:|||.||.||.:|.:.:...|:: |||||||||..:|...:.|.:|.:||.
Mouse    16 PDEKTLQVLRDMANRLRIRSIKATNSSTTSYLIPCSN-AEIMSVLFFYTMRYKQEDPENPDNDRC 79

  Fly    71 ILSKGHAAPILYAAWAEAGLFPIADLNNLRKIDSDLEGHPTPRLNFIDVGTGSLGQGVAVGAGMA 135
            |||||                                      |.|::|.||..|||:....|||
Mouse    80 ILSKG--------------------------------------LPFVNVATGWPGQGLGAACGMA 106

  Fly   136 YVGKNFDKADYRTYVVVGDGESAEGSIWESLHFAGHYKLDNLCVIFDVNRLGQSEATSLQHKLDV 200
            |.||.||:|.||.:.::||.||.|||:||:..||.:|.||||..||||||:|.|.:.|::|.:.:
Mouse   107 YTGKYFDQASYRVFCLLGDEESTEGSVWEAFAFASYYNLDNLMAIFDVNRIGHSSSMSVEHCIAI 171

  Fly   201 YRDRLEAFGFNAVVVDGHDVEELSKAFHCAAITKNKPTAIIAKTFKGRDFPNIEDLDNWHGKPL- 264
            |:.|.||||:|..||||.||:.|...|..||..:.||||::|||||.|..||:||.::|:|:|:
Mouse   172 YQKRCEAFGWNTYVVDGRDVKTLCHVFSQAAQVRGKPTAVVAKTFKARGMPNVEDAESWYGRPMP 236

  Fly   265 GDKAAEVVKHLEGLIVNKNVKLTPKPVPKTGAAPDVDINNIKLSSPPAYKLGDSIATRLAYGTAL 329
            .::|..:||.:|..|....:.:   |.|....:|.::|.||.::|||.|...|.::|:.|.|.||
Mouse   237 KERADAIVKLIESQIQTNKILV---PSPPIEDSPQINIMNICMTSPPVYVADDKVSTQRACGLAL 298

  Fly   330 AKIGQNNLRVVALDGDTKNSTFSDKLKNLDPQRYIECFIAEQNLVGVAVGAACRRRTVAFVSTFA 394
            ||:|..|.||:.|..||||..|||..|...|:|:|:|.|||||:|.||:|.:.|.||:.|..:||
Mouse   299 AKLGHENDRVIVLGSDTKNCNFSDIFKKEHPERFIQCCIAEQNMVNVALGCSTRDRTIVFAYSFA 363

  Fly   395 TFFTRAFDQIRMGAISQTNVNFVGSHCGCSIGEDGPSQMGLEDIAMFRTIPGSTIFYPSDAVSTE 459
            .||||||||||:|||||.|:|.:|.|||.|.|:|.|..|.|||:||||.||...:||||||||||
Mouse   364 AFFTRAFDQIRLGAISQININLIGCHCGVSTGDDNPYHMALEDLAMFRAIPNCVVFYPSDAVSTE 428

  Fly   460 RAVELAANTKGVCFIRTSRPNTCVIYDNEEPFTIGRGKVVRQKSSDEVLLIGAGITLYECLAAAD 524
            .||.||||||.:||||||:..|.:||..:|.|.||:.||||...:|:|::||||:||:|.|.||.
Mouse   429 HAVYLAANTKEMCFIRTSQAETAIIYTTQETFQIGQAKVVRHSDNDKVIVIGAGVTLHEALVAAA 493

  Fly   525 QLEKNCITVRVIDPFTVKPLDAELIIEHGKQCGGRVVVVEDHYQQGGLGEAVLSALAGERNFVVK 589
            :|.|..|::||||.||:||||...||.:.|..|||::.|||||.:||:|.||.:|::.|.|.||.
Mouse   494 ELSKEDISIRVIDLFTIKPLDIATIISNAKATGGRIITVEDHYPEGGIGGAVCAAVSMEPNIVVH 558

  Fly   590 HLYVPTVPRSGPPSVLIDMFGISARHVVNAVNEIL 624
            :|.|..|||||..:..:|..|||:||::.||..||
Mouse   559 NLAVMDVPRSGRCNEALDFSGISSRHIIVAVKCIL 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8036	NP_649812.2	PRK05899	8..624	CDD:235639	299/616 (49%)
		TPP_TK	19..270	CDD:238970	108/251 (43%)
		TPP_PYR_DXS_TK_like	324..478	CDD:132916	96/153 (63%)
		Transketolase_C	496..616	CDD:280875	62/119 (52%)
Tktl1	NP_113556.2	PRK05899	17..590	CDD:235639	298/614 (49%)
		TPP_enzymes	29..238	CDD:294952	107/247 (43%)
		TPP_PYR_DXS_TK_like	293..446	CDD:132916	95/152 (63%)
		Transketolase_C	463..585	CDD:280875	63/121 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832356
Domainoid	1	1.000	143	1.000	Domainoid score	I4623
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	782	1.000	Inparanoid score	I523
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58668
OrthoDB	1	1.010	-	-		D159833at33208
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	1	1.100	-	-	O	PTHR43195
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1857
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770