Protein Alignment CG8036 and TKTL1

DIOPT Version :10

• Sequence 1: NP_649812.2
• Gene: CG8036 / 41027
• FlyBaseID: FBgn0037607
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_036385.3
• Gene: TKTL1 / 8277
• HGNCID: 11835
• Length: 596
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 325/622 - (52%)
• Similarity: 430/622 - (69%)
• Gaps: 44/622 - (7%)

  Fly     5 KPEAKTVQDLKDLAQKLRIHSINATQASKSGHPTSCASIAEIMSVLFFQQLRLNLKHPRDPSSDR 69
            :|:..|:|.|:|:|.:||||||.||.::.|||||||:|.:||||||||..:|.....|.:|.:||
Human    15 RPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDNDR 79

  Fly    70 FILSKGHAAPILYAAWAEAGLFPIADLNNLRKIDSDLEGHPTPRLNFIDVGTGSLGQGVAVGAGM 134
            |:|:|                                      ||:|:||.||.||||:.|..||
Human    80 FVLAK--------------------------------------RLSFVDVATGWLGQGLGVACGM 106

  Fly   135 AYVGKNFDKADYRTYVVVGDGESAEGSIWESLHFAGHYKLDNLCVIFDVNRLGQSEATSLQHKLD 199
            ||.||.||:|.||.:.::.||||:|||:||::.||.:|.||||..||||||||.|.|...:|.::
Human   107 AYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCIN 171

  Fly   200 VYRDRLEAFGFNAVVVDGHDVEELSKAFHCAAITKNKPTAIIAKTFKGRDFPNIEDLDNWHGKPL 264
            :|:.|.||||:|..||||.|||.|.:.|..|:..|:||||::|||||||..|:|||.::||.||:
Human   172 IYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPM 236

  Fly   265 -GDKAAEVVKHLEGLI-VNKNVKLTPKPVPKTGAAPDVDINNIKLSSPPAYKLGDSIATRLAYGT 327
             .::|..::|.:|..| .::|:    .|.|....:|:|:|.:::::|||.|::||.||||.|.|.
Human   237 PRERADAIIKLIESQIQTSRNL----DPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGL 297

  Fly   328 ALAKIGQNNLRVVALDGDTKNSTFSDKLKNLDPQRYIECFIAEQNLVGVAVGAACRRRTVAFVST 392
            ||||:|..|.|||.|||||:.||||:......|:|:||||:||||:|.||:|.|.|.||:||.||
Human   298 ALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFAST 362

  Fly   393 FATFFTRAFDQIRMGAISQTNVNFVGSHCGCSIGEDGPSQMGLEDIAMFRTIPGSTIFYPSDAVS 457
            ||.|.|||||.||:|.::::|:|.:|||||.|:|:||.|||.|||||||||||..|||||:||||
Human   363 FAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVS 427

  Fly   458 TERAVELAANTKGVCFIRTSRPNTCVIYDNEEPFTIGRGKVVRQKSSDEVLLIGAGITLYECLAA 522
            ||.||.||||.||:|||||:||.|.|||..:|.|.||:.||:|...||:|.:||||||:||.|||
Human   428 TEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAA 492

  Fly   523 ADQLEKNCITVRVIDPFTVKPLDAELIIEHGKQCGGRVVVVEDHYQQGGLGEAVLSALAGERNFV 587
            ||:|.|..|.:||||.||:||||...|:...|...||::.|||||.|||:||||.:|::.:.:..
Human   493 ADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQ 557

  Fly   588 VKHLYVPTVPRSGPPSVLIDMFGISARHVVNAVNEIL 624
            |..|.|..||:||....|:||:||||||::.||..:|
Human   558 VHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCML 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8036	NP_649812.2	PRK05899	8..624	CDD:235639	323/617 (52%)
TKTL1	NP_036385.3	PRK05899	17..594	CDD:235639	323/618 (52%)