DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8036 and TKTL1

DIOPT Version :9

Sequence 1:NP_649812.2 Gene:CG8036 / 41027 FlyBaseID:FBgn0037607 Length:626 Species:Drosophila melanogaster
Sequence 2:NP_036385.3 Gene:TKTL1 / 8277 HGNCID:11835 Length:596 Species:Homo sapiens


Alignment Length:622 Identity:325/622 - (52%)
Similarity:430/622 - (69%) Gaps:44/622 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KPEAKTVQDLKDLAQKLRIHSINATQASKSGHPTSCASIAEIMSVLFFQQLRLNLKHPRDPSSDR 69
            :|:..|:|.|:|:|.:||||||.||.::.|||||||:|.:||||||||..:|.....|.:|.:||
Human    15 RPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDNDR 79

  Fly    70 FILSKGHAAPILYAAWAEAGLFPIADLNNLRKIDSDLEGHPTPRLNFIDVGTGSLGQGVAVGAGM 134
            |:|:|                                      ||:|:||.||.||||:.|..||
Human    80 FVLAK--------------------------------------RLSFVDVATGWLGQGLGVACGM 106

  Fly   135 AYVGKNFDKADYRTYVVVGDGESAEGSIWESLHFAGHYKLDNLCVIFDVNRLGQSEATSLQHKLD 199
            ||.||.||:|.||.:.::.||||:|||:||::.||.:|.||||..||||||||.|.|...:|.::
Human   107 AYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCIN 171

  Fly   200 VYRDRLEAFGFNAVVVDGHDVEELSKAFHCAAITKNKPTAIIAKTFKGRDFPNIEDLDNWHGKPL 264
            :|:.|.||||:|..||||.|||.|.:.|..|:..|:||||::|||||||..|:|||.::||.||:
Human   172 IYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPM 236

  Fly   265 -GDKAAEVVKHLEGLI-VNKNVKLTPKPVPKTGAAPDVDINNIKLSSPPAYKLGDSIATRLAYGT 327
             .::|..::|.:|..| .::|:    .|.|....:|:|:|.:::::|||.|::||.||||.|.|.
Human   237 PRERADAIIKLIESQIQTSRNL----DPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGL 297

  Fly   328 ALAKIGQNNLRVVALDGDTKNSTFSDKLKNLDPQRYIECFIAEQNLVGVAVGAACRRRTVAFVST 392
            ||||:|..|.|||.|||||:.||||:......|:|:||||:||||:|.||:|.|.|.||:||.||
Human   298 ALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFAST 362

  Fly   393 FATFFTRAFDQIRMGAISQTNVNFVGSHCGCSIGEDGPSQMGLEDIAMFRTIPGSTIFYPSDAVS 457
            ||.|.|||||.||:|.::::|:|.:|||||.|:|:||.|||.|||||||||||..|||||:||||
Human   363 FAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVS 427

  Fly   458 TERAVELAANTKGVCFIRTSRPNTCVIYDNEEPFTIGRGKVVRQKSSDEVLLIGAGITLYECLAA 522
            ||.||.||||.||:|||||:||.|.|||..:|.|.||:.||:|...||:|.:||||||:||.|||
Human   428 TEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAA 492

  Fly   523 ADQLEKNCITVRVIDPFTVKPLDAELIIEHGKQCGGRVVVVEDHYQQGGLGEAVLSALAGERNFV 587
            ||:|.|..|.:||||.||:||||...|:...|...||::.|||||.|||:||||.:|::.:.:..
Human   493 ADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQ 557

  Fly   588 VKHLYVPTVPRSGPPSVLIDMFGISARHVVNAVNEIL 624
            |..|.|..||:||....|:||:||||||::.||..:|
Human   558 VHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCML 594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8036NP_649812.2 PRK05899 8..624 CDD:235639 323/617 (52%)
TPP_TK 19..270 CDD:238970 120/251 (48%)
TPP_PYR_DXS_TK_like 324..478 CDD:132916 102/153 (67%)
Transketolase_C 496..616 CDD:280875 64/119 (54%)
TKTL1NP_036385.3 PRK05899 17..594 CDD:235639 323/618 (52%)
TPP_enzymes 30..245 CDD:294952 120/252 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 256..277 6/24 (25%)
TPP_PYR_DXS_TK_like 293..448 CDD:132916 102/154 (66%)
Transketolase_C 464..586 CDD:280875 65/121 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142506
Domainoid 1 1.000 136 1.000 Domainoid score I4919
eggNOG 1 0.900 - - E1_COG0021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG58668
OrthoDB 1 1.010 - - D159833at33208
OrthoFinder 1 1.000 - - FOG0001032
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100329
Panther 1 1.100 - - O PTHR43195
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.720

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