DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8036 and Tkt

DIOPT Version :9

Sequence 1:	NP_649812.2	Gene:	CG8036 / 41027	FlyBaseID:	FBgn0037607	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_072114.2	Gene:	Tkt / 64524	RGDID:	621036	Length:	655	Species:	Rattus norvegicus

Alignment Length:	623	Identity:	374/623 - (60%)
Similarity:	462/623 - (74%)	Gaps:	7/623 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YHKPEAKTVQDLKDLAQKLRIHSINATQASKSGHPTSCASIAEIMSVLFFQQLRLNLKHPRDPSS 67
            ||||:.:.:|.|||.|.:|||.||.||.|:.|||||||.|.||||:||||..:|.....||:|.:
  Rat    36 YHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKALDPRNPHN 100

  Fly    68 DRFILSKGHAAPILYAAWAEAGLFPIADLNNLRKIDSDLEGHPTPRLNFIDVGTGSLGQGVAVGA 132
            |||:||||||||||||.|||||..|.|:|.|||||.|||:|||.|:..|.||.|||||||:....
  Rat   101 DRFVLSKGHAAPILYAVWAEAGFLPEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAAC 165

  Fly   133 GMAYVGKNFDKADYRTYVVVGDGESAEGSIWESLHFAGHYKLDNLCVIFDVNRLGQSEATSLQHK 197
            ||||.||.||||.||.|.::||||.:|||:||::.|||.||||||..|||:||||||:...|||:
  Rat   166 GMAYTGKYFDKASYRVYCMLGDGEVSEGSVWEAMAFAGIYKLDNLVAIFDINRLGQSDPAPLQHQ 230

  Fly   198 LDVYRDRLEAFGFNAVVVDGHDVEELSKAFHCAAITKNKPTAIIAKTFKGRDFPNIEDLDNWHGK 262
            :|||:.|.||||::|::||||.||||.|||..|   |::||||||||||||....|||.:.||||
  Rat   231 VDVYQKRCEAFGWHAIIVDGHSVEELCKAFGQA---KHQPTAIIAKTFKGRGITGIEDKEAWHGK 292

  Fly   263 PLGDKAAE-VVKHLEGLIVNKNVKLTPKPVPKTGAAPDVDINNIKLSSPPAYKLGDSIATRLAYG 326
            ||....|| :::.:...:.:|...|.   .|....||.|||.||::.:||.||:||.||||.|||
  Rat   293 PLPKNMAEQIIQEIYSQVQSKKKILA---TPPQEDAPSVDIANIRMPTPPNYKVGDKIATRKAYG 354

  Fly   327 TALAKIGQNNLRVVALDGDTKNSTFSDKLKNLDPQRYIECFIAEQNLVGVAVGAACRRRTVAFVS 391
            .||||:|..:.|::||||||||||||:..|...|.|:|||:|||||:|.:|||.|.|.|||.|.|
  Rat   355 LALAKLGHASDRIIALDGDTKNSTFSELFKKEHPDRFIECYIAEQNMVSIAVGCATRDRTVPFCS 419

  Fly   392 TFATFFTRAFDQIRMGAISQTNVNFVGSHCGCSIGEDGPSQMGLEDIAMFRTIPGSTIFYPSDAV 456
            |||.|||||||||||.|||::|:|..|||||.||||||||||.|||:||||::|.||:|||||.|
  Rat   420 TFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPMSTVFYPSDGV 484

  Fly   457 STERAVELAANTKGVCFIRTSRPNTCVIYDNEEPFTIGRGKVVRQKSSDEVLLIGAGITLYECLA 521
            :||:||||||||||:||||||||...:||.|.|.|.:|:.|||.:...|:|.:||||:||:|.||
  Rat   485 ATEKAVELAANTKGICFIRTSRPENAIIYSNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALA 549

  Fly   522 AADQLEKNCITVRVIDPFTVKPLDAELIIEHGKQCGGRVVVVEDHYQQGGLGEAVLSALAGERNF 586
            ||:.|:|..|.|||:||||:||||.:||::..:...||::.|||||.:||:||||.:|:.||...
  Rat   550 AAEMLKKEKIGVRVLDPFTIKPLDKKLILDCARATKGRILTVEDHYYEGGIGEAVSAAVVGEPGV 614

  Fly   587 VVKHLYVPTVPRSGPPSVLIDMFGISARHVVNAVNEIL 624
            .|..|.|..|||||.|:.|:.||||....:|.||..::
  Rat   615 TVTRLAVSQVPRSGKPAELLKMFGIDKDAIVQAVKGLV 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8036	NP_649812.2	PRK05899	8..624	CDD:235639	370/616 (60%)
		TPP_TK	19..270	CDD:238970	159/250 (64%)
		TPP_PYR_DXS_TK_like	324..478	CDD:132916	110/153 (72%)
		Transketolase_C	496..616	CDD:280875	62/119 (52%)
Tkt	NP_072114.2	PRK05899	40..652	CDD:235639	370/617 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	343	1.000	Domainoid score	I1031
eggNOG	1	0.900	-	-		E1_COG0021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	789	1.000	Inparanoid score	I487
OMA	1	1.010	-	-		QHG58668
OrthoDB	1	1.010	-	-		D159833at33208
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		mtm9097
orthoMCL	1	0.900	-	-		OOG6_100329
Panther	1	1.100	-	-	LDO	PTHR43195
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1857
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840