DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8036 and tktl2

DIOPT Version :9

Sequence 1:	NP_649812.2	Gene:	CG8036 / 41027	FlyBaseID:	FBgn0037607	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_989227.1	Gene:	tktl2 / 394835	XenbaseID:	XB-GENE-1002824	Length:	625	Species:	Xenopus tropicalis

Alignment Length:	620	Identity:	395/620 - (63%)
Similarity:	470/620 - (75%)	Gaps:	4/620 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SYHKPEAKTVQDLKDLAQKLRIHSINATQASKSGHPTSCASIAEIMSVLFFQQLRLNLKHPRDPS 66
            :|.|||.|.:|.|||.|.:||||||.||.||.|||||||.|.||::|||||..:|.....|.:.:
Frog     3 TYQKPEDKELQALKDAANRLRIHSIRATCASNSGHPTSCCSAAEVLSVLFFNTMRYEAADPGNAN 67

  Fly    67 SDRFILSKGHAAPILYAAWAEAGLFPIADLNNLRKIDSDLEGHPTPRLNFIDVGTGSLGQGVAVG 131
            :|||:||||||||||||||||||....:||.||||||.||||||||:|.|:||.|||||||:...
Frog    68 NDRFVLSKGHAAPILYAAWAEAGYIKESDLLNLRKIDCDLEGHPTPKLPFVDVATGSLGQGLGAS 132

  Fly   132 AGMAYVGKNFDKADYRTYVVVGDGESAEGSIWESLHFAGHYKLDNLCVIFDVNRLGQSEATSLQH 196
            .||||.||.||||.||.|.::|||||:||::||::.||.||.||||..||||||||||||..|||
Frog   133 CGMAYTGKYFDKASYRVYCLLGDGESSEGAVWEAMAFASHYHLDNLVAIFDVNRLGQSEAAPLQH 197

  Fly   197 KLDVYRDRLEAFGFNAVVVDGHDVEELSKAFHCAAITKNKPTAIIAKTFKGRDFPNIEDLDNWHG 261
            :.|:|..|.||||:|..|||||||.||..||..||..|:|||||||||:||:....:|:.|||||
Frog   198 QTDIYMKRCEAFGWNTYVVDGHDVAELCHAFWQAAHVKDKPTAIIAKTYKGKGISGVENEDNWHG 262

  Fly   262 KPL-GDKAAEVVKHLEGLIVNKNVKLTPKPVPKTGAAPDVDINNIKLSSPPAYKLGDSIATRLAY 325
            ||: .|||..::..::..| ..|.||:|. || ...||.:.|::|...|||.||:||.||||.||
Frog   263 KPMPKDKAESIINEIQSQI-QTNRKLSPL-VP-IADAPKISISDITFPSPPNYKIGDKIATRRAY 324

  Fly   326 GTALAKIGQNNLRVVALDGDTKNSTFSDKLKNLDPQRYIECFIAEQNLVGVAVGAACRRRTVAFV 390
            |.||||:|..|.||:||||||||||||:..|...|.|||||||||||:|.||:|.|.|.|||||.
Frog   325 GLALAKLGHANSRVIALDGDTKNSTFSEIFKKEHPDRYIECFIAEQNMVSVAMGCATRNRTVAFA 389

  Fly   391 STFATFFTRAFDQIRMGAISQTNVNFVGSHCGCSIGEDGPSQMGLEDIAMFRTIPGSTIFYPSDA 455
            ||||.|.:||:|.||||||||:|||..|||||.||||||||||.|||:||||.||..|:|||||.
Frog   390 STFAAFLSRAYDHIRMGAISQSNVNLCGSHCGVSIGEDGPSQMALEDLAMFRAIPTCTVFYPSDG 454

  Fly   456 VSTERAVELAANTKGVCFIRTSRPNTCVIYDNEEPFTIGRGKVVRQKSSDEVLLIGAGITLYECL 520
            ||||.||.|||||.|:||||||||:|.|||..:|.|.||:.|||||.|||.|.:||||:||:|.|
Frog   455 VSTEHAVFLAANTPGICFIRTSRPDTAVIYSPDEKFEIGQAKVVRQSSSDRVTVIGAGVTLHEAL 519

  Fly   521 AAADQLEKNCITVRVIDPFTVKPLDAELIIEHGKQCGGRVVVVEDHYQQGGLGEAVLSALAGERN 585
            ||||:|.|..|.:||:||||:|||||..|:..|:..||.::.|||||::|||||||.:|:|||..
Frog   520 AAADELAKQGINIRVVDPFTIKPLDAATILSSGRATGGHIITVEDHYREGGLGEAVCAAVAGEPG 584

  Fly   586 FVVKHLYVPTVPRSGPPSVLIDMFGISARHVVNAV 620
            |:|:.|.|..|||||.|:.|:|:||||:|.:|.||
Frog   585 FIVQTLAVRGVPRSGKPTELLDLFGISSRCIVEAV 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8036	NP_649812.2	PRK05899	8..624	CDD:235639	391/614 (64%)
		TPP_TK	19..270	CDD:238970	164/251 (65%)
		TPP_PYR_DXS_TK_like	324..478	CDD:132916	113/153 (74%)
		Transketolase_C	496..616	CDD:280875	72/119 (61%)
tktl2	NP_989227.1	PRK05899	9..621	CDD:235639	391/614 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1069
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69456
Inparanoid	1	1.050	783	1.000	Inparanoid score	I515
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159833at33208
OrthoFinder	1	1.000	-	-		FOG0001032
OrthoInspector	1	1.000	-	-		otm48561
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1857
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060